long-term outcomes

Early Control of Ulcerative Colitis and Its Impact on Long-Term Outcomes: Insights from the UNIFI Phase 3 Study

By MedXY 08/26/2025

Achieving disease clearance early after induction therapy with ustekinumab in ulcerative colitis patients predicts sustained clinical remission, symptom control, and improved quality of life over four years.

Clinical Updates Wellness & Lifestyle

Nine-Year Outcomes After Lacunar and Mild Cortical Ischemic Stroke: Long-Term Functional, Cognitive, and Vascular Impacts

By MedXY 08/26/2025

This longitudinal study reveals persistent cognitive, physical, and vascular challenges up to 9 years after minor lacunar or cortical ischemic stroke, emphasizing different risks and recovery patterns by stroke subtype.

Clinical Updates Wellness & Lifestyle

Long-Term Durability of Active Surveillance in Small, Low-Risk Papillary Thyroid Cancer: Age-Related Outcomes and Clinical Implications

By MedXY 08/22/2025

Active surveillance is a durable management strategy for small, low-risk papillary thyroid cancer, especially among older adults who show significantly lower crossover rates to surgery.

Clinical Updates Wellness & Lifestyle

Serum Alpha-Linolenic Acid and Long-Term Multiple Sclerosis Activity and Progression: Insights from the BENEFIT Study

By MedXY 08/20/2025

Higher baseline serum alpha-linolenic acid levels predict reduced multiple sclerosis activity, relapses, and disability progression up to 11 years post clinical onset in a large prospective study.

Clinical Updates Wellness & Lifestyle

Long-Term Functional Recovery and Survival after VA-ECMO: Insights from a 26-Center Prospective Cohort Study

By MedXY 08/17/2025

A multicenter study reveals that 30% of adult VA-ECMO patients survive 12 months without new disability, with most disability developing within the first 6 months. Functional independence and employment improve by 12 months post-ECMO.

Clinical Updates Wellness & Lifestyle

Five-Year Outcomes of Per-Oral Endoscopic Myotomy vs. Laparoscopic Heller’s Myotomy Plus Dor Fundoplication in Idiopathic Achalasia

By MedXY 08/14/2025

A multicenter randomized trial shows POEM is non-inferior to LHM plus Dor fundoplication for achalasia symptom control at 5 years, with differing reflux profiles.

Clinical Updates Wellness & Lifestyle

Durable Efficacy and Long-term Safety of AAV Gene Therapy in Severe Hemophilia B: 13-Year Follow-up Results

By MedXY 08/01/2025

A single AAV gene therapy infusion for severe hemophilia B led to sustained factor IX expression, substantial reduction in bleeding and factor use, and no late safety concerns over 13 years.

Clinical Updates Wellness & Lifestyle

Long-Term Fracture Risk After Menopausal Hormone Therapy: New Insights from a Landmark Study

By MedXY 07/30/2025

Large-scale UK data reveal a transient increase but sustained long-term reduction in fracture risk after discontinuing menopausal HRT, challenging prior assumptions and guiding future clinical decisions.