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Clotting Factor Concentrates vs Frozen Plasma in Severe Trauma Resuscitation: Insights from the FiiRST-2 Randomized Trial

Posted inAnesthesiology Clinical Updates Critical Care news

Clotting Factor Concentrates vs Frozen Plasma in Severe Trauma Resuscitation: Insights from the FiiRST-2 Randomized Trial

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By MedXY 09/23/2025

The FiiRST-2 trial found no superiority of clotting factor concentrates over frozen plasma for initial resuscitation in severely bleeding trauma patients, with similar transfusion needs and safety outcomes.

Comparative Efficacy of Vascular Closure Strategies After TF-TAVI: Insights from ACCESS-TAVI and CHOICE-CLOSURE Trials

Posted inCardiology Specialties

Comparative Efficacy of Vascular Closure Strategies After TF-TAVI: Insights from ACCESS-TAVI and CHOICE-CLOSURE Trials

Posted by

By MedXY 08/16/2025

Recent randomized trials compare suture/plug-based versus suture-only and pure plug-based vascular closure techniques after TF-TAVI, revealing differences in complication rates and hemostasis times.

SGLT2 Inhibitors Reduce Kidney Events, Hospitalization and Death Regardless of Diabetes or Albuminuria: A SMART-C Meta-Analysis Interpretation
Conservative Dialysis Strategy Accelerates Kidney Recovery in Dialysis-Requiring AKI — Early Randomized Evidence from LIBERATE-D
When Cystatin C Says the Kidneys Are Worse: Discordant eGFR and High Risk — Findings from 860,000+ Patients
A‑E‑I‑O‑U and Sometimes Why—Dialysis in Acute Kidney Injury
Each Hour Sitting Counts: Sedentary Time Linked to Lower Intrinsic Capacity and Faster Decline in Older Adults

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