hemostasis – Medxy AI

Prophylactic Tranexamic Acid in General Surgery: Significant Reduction in Major Bleeding Without Thromboembolic Risk

By MedXY 12/24/2025

A systematic review and meta-analysis of 26 RCTs reveals that prophylactic tranexamic acid (TXA) significantly reduces blood loss and transfusion needs in general surgery. While safety profiles are favorable, procedural nuances—particularly in abdominal versus hepatobiliary cases—highlight the importance of tailored clinical application.

Clinical Updates General Surgery news

Cryopreserved Versus Liquid-Stored Platelets in Surgical Bleeding: Insights from the CLIP-II Randomized Noninferiority Trial

By MedXY 12/13/2025

The CLIP-II trial evaluated dimethyl sulfoxide-cryopreserved platelets with extended shelf-life against conventional liquid-stored platelets in cardiac surgery bleeding, finding noninferiority was not established and cryopreserved platelets showed reduced hemostatic effectiveness despite similar safety profiles.

Anesthesiology Clinical Updates Critical Care news

Clotting Factor Concentrates vs Frozen Plasma in Severe Trauma Resuscitation: Insights from the FiiRST-2 Randomized Trial

By MedXY 09/23/2025

The FiiRST-2 trial found no superiority of clotting factor concentrates over frozen plasma for initial resuscitation in severely bleeding trauma patients, with similar transfusion needs and safety outcomes.

Cardiology Specialties

Comparative Efficacy of Vascular Closure Strategies After TF-TAVI: Insights from ACCESS-TAVI and CHOICE-CLOSURE Trials

By MedXY 08/16/2025

Recent randomized trials compare suture/plug-based versus suture-only and pure plug-based vascular closure techniques after TF-TAVI, revealing differences in complication rates and hemostasis times.