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  • first-episode psychosis
Balancing the Scale: Early Antipsychotic Dose Reduction Linked to Better Long-term Functioning Despite Short-term Relapse Risks
Posted innews Psychiatry

Balancing the Scale: Early Antipsychotic Dose Reduction Linked to Better Long-term Functioning Despite Short-term Relapse Risks

Posted by MedXY By MedXY 01/16/2026
The HAMLETT trial demonstrates that early dose reduction after first-episode psychosis increases short-term relapse risk but correlates with superior functional outcomes at three to four years, suggesting a potential 'learning effect' for patients managing their condition.
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Balancing Risks and Benefits: Early Antipsychotic Dose Reduction Versus Maintenance After First-Episode Psychosis Remission
Posted inClinical Updates news Psychiatry Specialties

Balancing Risks and Benefits: Early Antipsychotic Dose Reduction Versus Maintenance After First-Episode Psychosis Remission

Posted by MedXY By MedXY 10/01/2025
A randomized clinical trial reveals early dose reduction of antipsychotics after first-episode psychosis remission increases short-term relapse risk and lowers quality of life, but may improve long-term functioning over four years.
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