endocrinology – Medxy AI

Impact of Polygenic Risk Scores on the Clinical Presentation and Glycaemic Variability of GCK-MODY

By MedXY 03/20/2026

This article explores how polygenic background modifies GCK-MODY clinical phenotypes, influencing HbA1c levels and diagnostic thresholds. Findings highlight the distinct polygenic patterns in GCK-MODY compared to HNF1A-MODY, emphasizing the interaction between monogenic and polygenic factors in diabetes.

Cardiology Diabetes & Endocrinology news

Metformin-Induced Blunting of Exercise-Mediated Vascular Improvements in Adults with Metabolic Risk

By MedXY 03/20/2026

This report examines how metformin may interfere with exercise-induced improvements in vascular insulin sensitivity and aerobic fitness in adults at risk for metabolic syndrome.

Diabetes & Endocrinology Internal Medicine news

Breaking the Fasting Mandate: Is It Time to Re-evaluate Levothyroxine Administration?

By MedXY 03/18/2026

A randomized clinical trial demonstrates that a 15% dose increase allows levothyroxine to be taken with breakfast without compromising TSH stability, significantly improving patient preference and well-being.

Diabetes & Endocrinology news

Beyond Thyroglobulin: Uncovering the Alternative Path for Thyroid Hormone Synthesis

By MedXY 03/10/2026

This study explores how the body synthesizes thyroid hormones without thyroglobulin, the primary precursor protein. Research using Tg-KO mice reveals an inefficient but life-sustaining mechanism involving goiter growth and the iodination of proteins from dead thyrocytes, challenging long-held views in endocrinology.

Clinical Updates Diabetes & Endocrinology news OB/GYN & Women's Health

Management of Graves’ Disease During Pregnancy: Clinical Insights from the Danish PRETHYR Multicenter Study

By MedXY 03/09/2026

This clinical review synthesizes findings from the PRETHYR study on antithyroid drug use in pregnant women, highlighting treatment transitions, biochemical predictors, and the impact of specialist-led management in Denmark.

Diabetes & Endocrinology news Oncology

Beyond Mandatory Resection: Active Surveillance Proves Safe for RAS-Positive Thyroid Nodules

By MedXY 03/06/2026

A new study suggests that isolated RAS mutations in Bethesda III and IV thyroid nodules do not always require surgery. With a 34% malignancy rate and low growth incidence, active surveillance emerges as a viable, safe alternative for appropriately selected patients.

Diabetes & Endocrinology news Radiology

Oxygen-Guided Success: A New Frontier in Adrenal Venous Sampling for Primary Aldosteronism

By MedXY 03/06/2026

Researchers have discovered that measuring oxygen partial pressure (pO2) can significantly improve the accuracy and speed of Adrenal Venous Sampling, providing a cost-effective tool for diagnosing Primary Aldosteronism.

General Surgery news Otorhinolaryngology

PTH-Guided Selective Calcium Supplementation After Total Thyroidectomy: Is Routine Prophylaxis Still Necessary?

By MedXY 02/19/2026

A multicenter randomized clinical trial demonstrates that selective calcium supplementation based on early postoperative PTH levels is as effective as routine prophylaxis in preventing hypocalcemia after total thyroidectomy, offering a strategy to minimize overtreatment and resource use.

Diabetes & Endocrinology news Public Health

Managing Obesity as a Chronic Disease: The 2026 WHO Guidelines on GLP-1 Therapies

By MedXY 02/05/2026

The World Health Organization (WHO) has released its landmark 2026 guidelines on GLP-1 therapies for obesity, reclassifying the condition as a chronic, relapsing disease requiring long-term pharmacological and behavioral management while emphasizing global health equity.

Diabetes & Endocrinology Internal Medicine news

Selenium Supplementation Fails to Improve Remission or Quality of Life in Graves’ Hyperthyroidism: Findings from the GRASS RCT

By MedXY 01/01/2026

The GRASS trial, a double-blind multi-centre RCT, found that adding 200 µg of selenium daily to standard antithyroid drug therapy does not increase remission rates or improve quality of life in patients with newly diagnosed Graves' hyperthyroidism, suggesting no clinical benefit for routine supplementation.

Diabetes & Endocrinology Family Medicine & Nutrition Medical News news Specialties

How Birth Control Pills and Smoking Reshape Steroid Hormones

By MedXY 08/10/2025

A large study shows oral contraceptives and smoking substantially alter steroid hormone profiles in healthy adults, with implications for disease risk, diagnostics, and treatment decisions.

Family Medicine & Nutrition news Specialties

30 Practical Tips for Effective and Healthy Weight Loss

By MedXY 08/05/2025

Discover 30 scientifically backed tips from an endocrinologist to help you lose weight healthily and sustainably through diet, exercise, and lifestyle changes.

Diabetes & Endocrinology Medical News news Specialties

Top U.S. Hospitals for Diabetes and Endocrinology: Interpreting the 2025–2026 U.S. News Rankings

By MedXY 07/30/2025

A critical analysis of the 2025–2026 U.S. News rankings for diabetes and endocrinology care, examining methodology, clinical impact, and implications for patient care and referral.