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Beyond the Restrictive Paradigm: Redefining Left Ventricular Phenotypes and Prognosis in Cardiac Amyloidosis
Posted inCardiology Internal Medicine news

Beyond the Restrictive Paradigm: Redefining Left Ventricular Phenotypes and Prognosis in Cardiac Amyloidosis

Posted by MedXY By MedXY 03/02/2026
A large-scale retrospective study challenges the classic view of cardiac amyloidosis, revealing that while restriction is the dominant phenotype at diagnosis, nearly one-third of patients present with preserved function, and progression patterns differ significantly between TTR and AL subtypes.
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Restrictive Physiology, Not Systolic Failure, Defines the Clinical Landscape of Cardiac Amyloidosis
Posted inCardiology Internal Medicine news

Restrictive Physiology, Not Systolic Failure, Defines the Clinical Landscape of Cardiac Amyloidosis

Posted by MedXY By MedXY 02/28/2026
A large-scale study identifies restrictive physiology as the dominant phenotype in cardiac amyloidosis. While preserved function offers better survival, rapid progression to restriction underscores the importance of early diagnosis and monitoring beyond simple ejection fraction metrics.
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Echocardiographic Remodeling and Atrial Dynamics with Mavacamten in Nonobstructive Hypertrophic Cardiomyopathy: Insights from the ODYSSEY-HCM Trial
Posted inCardiology Clinical Updates news

Echocardiographic Remodeling and Atrial Dynamics with Mavacamten in Nonobstructive Hypertrophic Cardiomyopathy: Insights from the ODYSSEY-HCM Trial

Posted by MedXY By MedXY 01/17/2026
This exploratory analysis of the ODYSSEY-HCM trial demonstrates that mavacamten induces modest regression of left ventricular hypertrophy and improves diastolic and left atrial function in nonobstructive HCM, despite a 21.5% incidence of reversible systolic reduction.
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GLIDE Score Emerges as a Robust Predictor of Success in Direct Transcatheter Tricuspid Valve Annuloplasty
Posted inCardiology news

GLIDE Score Emerges as a Robust Predictor of Success in Direct Transcatheter Tricuspid Valve Annuloplasty

Posted by MedXY By MedXY 01/05/2026
A study of 204 patients demonstrates that the GLIDE Score, originally for edge-to-edge repair, effectively predicts procedural success in transcatheter tricuspid valve annuloplasty (TTVA), with predictive accuracy further enhanced by incorporating annular diameter measurements.
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Why the Parasternal Window May Be the New Gold Standard for Aortic Regurgitation Quantitation
Posted inCardiology news Radiology

Why the Parasternal Window May Be the New Gold Standard for Aortic Regurgitation Quantitation

Posted by MedXY By MedXY 01/03/2026
A landmark study demonstrates that measuring flow convergence from the parasternal long-axis window significantly outperforms apical PISA in feasibility and matches Cardiac MRI accuracy for assessing aortic regurgitation severity.
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Unlocking Echocardiograms to Treat Undiagnosed Hypertension — The NOTIFY‑LVH Randomized Trial
Posted inCardiology news

Unlocking Echocardiograms to Treat Undiagnosed Hypertension — The NOTIFY‑LVH Randomized Trial

Posted by MedXY By MedXY 12/03/2025
A centralized notification and support pathway using prior echocardiographic LVH increased antihypertensive initiation and new hypertension diagnoses versus usual care in a pragmatic randomized trial.
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  • Genetic Breakthrough: How SNUPN Gene Variants Lead to Spinocerebellar Atrophy
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