Quantitative Retinal Leakage on Ultra-Widefield Imaging: A New Biomarker for Predicting Diabetic Retinopathy Progression

Quantitative Retinal Leakage on Ultra-Widefield Imaging: A New Biomarker for Predicting Diabetic Retinopathy Progression

A post hoc analysis of the DRCR Retina Network Protocol AA reveals that automated quantitative leakage index on ultra-widefield fluorescein angiography independently predicts the 4-year risk of DRSS worsening and vision-threatening complications in patients with nonproliferative diabetic retinopathy.
Indole-3-Propionic Acid Bridges Gut Dysfunction and Diabetic Retinopathy — A Biomarker and Therapeutic Avenue

Indole-3-Propionic Acid Bridges Gut Dysfunction and Diabetic Retinopathy — A Biomarker and Therapeutic Avenue

A Gut 2025 study identifies microbially produced indole-3-propionic acid (IPA) as a protective metabolite linking restored intestinal tryptophan handling to prevention of diabetic retinopathy in mice and associates low serum IPA with retinopathy in people with type 2 diabetes.