cognition – Medxy AI

Polygenic Influences and Anticholinergic Burden: Unraveling Their Joint Impact on Cognition and Brain Structure in Psychosis Spectrum Disorders

By MedXY 10/30/2025

This study reveals that genetic predispositions interact with anticholinergic medication burden to influence cognitive deficits and brain gray matter volume reductions in psychosis spectrum disorders, offering new insights into personalized treatment strategies.

Neurology news Pathology & Lab Medicine Public Health

Moderate-to-Vigorous Physical Activity, p-tau181, and Cognition in Older Adults with Memory Complaints: Insights from the MAPT Study

By MedXY 10/20/2025

Higher moderate-to-vigorous physical activity slows p-tau181 increase, a marker of Alzheimer’s pathology, but elevated p-tau181 diminishes exercise-related cognitive benefits in older adults.

Neurology Public Health Specialties

Life Course Air Pollution Exposure Linked to Cognitive Decline and Brain Structural Changes in Older Adults

By MedXY 10/20/2025

A population-based study reveals that midlife exposure to air pollutants such as nitrogen dioxide and particulate matter is associated with cognitive decline and brain structural alterations by age 69-71, highlighting long-term neurological risks of ambient air pollution.

Neurology news Public Health

Life Course Air Pollution Exposure and Cognitive Decline: Insights from the 1946 British Birth Cohort

By MedXY 10/20/2025

This population-based study reveals that midlife exposure to nitrogen dioxide and particulate matter correlates with poorer cognitive function and adverse brain structural changes in later life, underscoring the neurocognitive risks of air pollution.

Neurology news Respiratory Specialties

Cardiorespiratory Exercise Enhances Cognitive Function After Ischemic Stroke: Insights from the PISCES-ZODIAC Trial

By MedXY 08/31/2025

An 8-week cardiorespiratory exercise program initiated 2 months after ischemic stroke improved cognitive performance at 12 months, despite no significant preservation of hippocampal volume compared with control. The intervention was safe and feasible, offering promising avenues for poststroke cognitive care.

Clinical Updates Family Medicine & Nutrition Neurology news Specialties

Walking and Dietary Interventions Offer Cognitive Protection in APOE ε4 Carriers: New Evidence from Longitudinal and Multinational Trials

By MedXY 07/30/2025

Regular walking and lifestyle interventions slow cognitive decline, especially in APOE ε4 carriers at heightened Alzheimer’s risk, with effects pronounced in women. Evidence underscores the value of simple activity and healthy diet for at-risk older adults.

Clinical Updates Medical News Neurology Specialties

Structured Lifestyle Interventions Deliver Superior Cognitive Benefits over Self-Guided Approaches in At-Risk Older Adults

By MedXY 07/29/2025

A large phase 3 trial reveals that structured, multidomain lifestyle interventions significantly improve cognition in older adults at risk for cognitive decline, outperforming self-guided strategies.