case report – Medxy AI

Use of Teplizumab to Modulate Stage 2 Type 1 Diabetes in Two Individuals With Autoimmune Polyendocrine Syndrome 1

By MedXY 12/30/2025

This case report explores the immunomodulatory effects of teplizumab in two adolescents with APS-1-associated stage 2 T1D, highlighting potential for preservation of β-cell function.

news Ophthalmology Rheumatology

Pentosan Polysulfate Maculopathy Following Subcutaneous Injections for Arthritis: A Case Series

By MedXY 12/26/2025

Three cases of pentosan polysulfate maculopathy occurred after subcutaneous administration for arthritis at much lower cumulative doses than oral use, highlighting retinal toxicity risk and need for early detection.

Neurology news Pediatrics

Acute-Onset Axonal Neuropathy Following Infection in Children with Biallelic RCC1 Variants: A Case Series

By MedXY 12/23/2025

Case series reports acute axonal neuropathy post-infection in children with biallelic RCC1 variants, often misdiagnosed as Guillain-Barré syndrome, showing variable severity and highlighting impaired nucleocytoplasmic transport as pathogenic mechanism.

Dermatology Hematology-Oncology news

JAK2 Gene Fusions in Adult Patients with Mycosis Fungoides and CD30-Positive Lymphoproliferative Disorders: A Case Series

By MedXY 11/27/2025

This case series highlights the presence and clinical significance of JAK2 gene fusions across a spectrum of cutaneous T-cell lymphomas, including indolent and aggressive presentations.

news Ophthalmology Otorhinolaryngology

Clinical Findings and Molecular Genetics of USH1C-Associated Usher Syndrome: A Retrospective Case Series

By MedXY 11/27/2025

This case series reviews clinical features, genetic variants, visual outcomes, and psychosocial impact in 28 patients with USH1C-associated Usher syndrome, highlighting slow retinal degeneration and significant social burden.

news Orthopedics Otorhinolaryngology

Treatment of a Mandibular Molar with Primary Failure of Eruption: A Case Report

By MedXY 11/13/2025

A 12-year-old female with primary failure of eruption (PFE) affecting the right mandibular first molar is treated successfully via extraction and orthodontic repositioning, restoring function and occlusion.

Infectious Diseases Neurology news

Emergence of a Novel Mammarenavirus Closely Related to Lassa Virus in a Patient with Meningoencephalitis in Chad

By MedXY 11/13/2025

A 37-year-old man developed meningoencephalitis caused by a novel mammarenavirus genetically related to Lassa virus after travel to Chad, highlighting emergence of a new pathogen with distinct clinical features.

Neurology news Rheumatology

Outcomes of Maintenance Immunotherapy in Susac Syndrome

By MedXY 11/02/2025

This case series evaluates relapse rates associated with various maintenance immunotherapies in 54 patients with Susac syndrome, highlighting treatment efficacy and challenges in managing this rare autoimmune disorder.

Dermatology news Pediatrics

Oral Manifestations of Lamellar Ichthyosis: A Case Report of Two Siblings

By MedXY 10/25/2025

Two brothers with lamellar ichthyosis presented with enamel defects and dental caries; dental rehabilitation with preventive measures was completed alongside dermatologic care.

Dentistry Plastic Surgery Rehabilitation Medicine

Minimally Invasive Ceramic Laminate Veneers for Maxillary Anterior Esthetic Rehabilitation: A 12+ Years Follow-Up

By MedXY 10/24/2025

This case report details a long-term successful esthetic rehabilitation using thin feldspathic ceramic laminate veneers to close diastemas and improve tooth morphology, with a follow-up exceeding 12 years.

Neurology news

Severe Symptomatic Arterial Vasospasm Following Pituitary Surgery: A Rare Case and Systematic Review of the Literature

By MedXY 10/22/2025

We report a rare case of severe symptomatic arterial vasospasm after pituitary surgery, accompanied by a systematic review highlighting risk factors, clinical presentation, treatment strategies, and outcomes for this life-threatening complication.

Neurology news Ophthalmology

Vogt-Koyanagi-Harada Syndrome Presenting with Ophthalmic and Neurological Symptoms: A Case Report

By MedXY 10/05/2025

A 38-year-old male with bilateral blurred vision and neurological symptoms was diagnosed with Vogt-Koyanagi-Harada syndrome and managed successfully with corticosteroids and immunosuppressants.

Gastroenterology news Specialties

Primary Sclerosing Cholangitis in a 45-Year-Old Male: A Case Report

By MedXY 10/02/2025

A 45-year-old male presents with cholestatic liver enzyme elevation and pruritus, diagnosed with primary sclerosing cholangitis confirmed by imaging and liver biopsy. Clinical management and prognosis are discussed.

Clinical Updates Diabetes & Endocrinology news Specialties

Cutaneous Presentation of Hyperthyroidism in a Middle-aged Female: A Case Report

By MedXY 09/28/2025

A 45-year-old female presented with pruritic skin lesions and weight loss, diagnosed with hyperthyroidism manifesting cutaneous symptoms. Treatment with antithyroid medication led to symptom resolution.

news Public Health Respiratory Specialties

Rare Case of Multifocal Cutaneous Tuberculosis in an Immunocompetent Patient

By MedXY 09/27/2025

We present a case of multifocal cutaneous tuberculosis in a 35-year-old immunocompetent woman, highlighting diagnostic challenges and effective management with standard anti-tubercular therapy.

Cardiology news Specialties

Spontaneous Intramuscular Hematoma in a Patient with Warfarin Therapy: A Case Report

By MedXY 09/04/2025

A 75-year-old male on warfarin presented with spontaneous thigh swelling and pain, diagnosed as spontaneous intramuscular hematoma, successfully managed with supportive care and warfarin reversal.

Infectious Diseases Nephrology news Specialties Urology

Case Report: Unilateral Renal Agenesis Presenting as Recurrent Urinary Tract Infections in a 25-Year-Old Woman

By MedXY 08/26/2025

A 25-year-old woman with recurrent urinary tract infections was diagnosed with unilateral renal agenesis, highlighting the importance of imaging in persistent urinary symptoms.