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Dissecting the Care Bundle: Mediation Analysis of Key Components Driving Improved Outcomes in INTERACT3 for Acute Intracerebral Hemorrhage
Posted inClinical Updates Neurology news Nursing & care Specialties

Dissecting the Care Bundle: Mediation Analysis of Key Components Driving Improved Outcomes in INTERACT3 for Acute Intracerebral Hemorrhage

Posted by By MedXY 09/22/2025
Mediation analysis of INTERACT3 reveals that systolic blood pressure and blood glucose control are primary drivers of functional recovery benefits in acute intracerebral hemorrhage care bundles.
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Equally Effective Dual Therapy Combinations for Hypertension in Indian Patients: Insights from a Landmark Randomized Trial
Posted inCardiology Clinical Updates

Equally Effective Dual Therapy Combinations for Hypertension in Indian Patients: Insights from a Landmark Randomized Trial

Posted by By MedXY 09/19/2025
This multicenter randomized trial in India shows that three dual antihypertensive combinations—amlodipine-perindopril, perindopril-indapamide, and amlodipine-indapamide—are equally effective and well-tolerated for 24-hour blood pressure control in South Asian adults.
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Amiloride vs Spironolactone for Resistant Hypertension: A New Alternative Backed by Randomized Trial Evidence
Posted inCardiology Clinical Updates news

Amiloride vs Spironolactone for Resistant Hypertension: A New Alternative Backed by Randomized Trial Evidence

Posted by By MedXY 09/19/2025
A recent randomized clinical trial demonstrates amiloride's noninferiority to spironolactone in lowering systolic blood pressure in resistant hypertension, offering a promising alternative therapy.
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Baxdrostat: A Promising New Agent for Managing Uncontrolled and Resistant Hypertension
Posted inCardiology Specialties

Baxdrostat: A Promising New Agent for Managing Uncontrolled and Resistant Hypertension

Posted by By MedXY 09/11/2025
Baxdrostat, a novel aldosterone synthase inhibitor, significantly reduces systolic blood pressure in patients with uncontrolled or resistant hypertension, offering a new therapeutic option with a favorable safety profile.
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Balancing Benefits and Harms of Intensive Blood Pressure Control Across Cardiovascular Risk Levels
Posted inCardiology Clinical Updates news Specialties

Balancing Benefits and Harms of Intensive Blood Pressure Control Across Cardiovascular Risk Levels

Posted by By MedXY 08/12/2025
Intensive blood pressure control reduces cardiovascular events across all risk levels, with greater absolute benefits in higher-risk patients despite increased adverse events, supporting tailored treatment based on cardiovascular risk.
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  • Venetoclax‑Obinutuzumab in First‑Line CLL: Efficacy Preserved in Unfit Patients — but Dose Intensity Matters
  • Long-term Outcomes in Congenital TTP: Registry Data Show Prophylactic Plasma Reduces Clinical Events but Symptoms and Product Burden Persist
  • DAGO2 (daunorubicin/cytarabine + fractionated gemtuzumab) Outperforms CPX‑351 in Older Adults with Non‑Adverse‑Risk AML: NCRI AML18 Results
  • DAGO2 (daunorubicin+cytarabine+fractionated gemtuzumab) outperforms CPX‑351 in older adults with non‑adverse‑risk AML: insights from NCRI AML18
  • Venetoclax plus gilteritinib shows potent preclinical activity in FLT3‑mutant BCL11B‑a lineage‑ambiguous leukemia: translational opportunities and trial design considerations
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