acute ischemic stroke

The NIHSS Bias: Why Right-Sided Middle Cerebral Artery Strokes Carry Higher Mortality and Complication Risks

By MedXY 03/15/2026

A retrospective study of 489,360 patients reveals that right-sided middle cerebral artery strokes are associated with significantly higher inpatient mortality and complications compared to left-sided strokes, likely due to inherent scoring biases in the NIHSS that underestimate nondominant hemisphere deficits.

Clinical Updates Neurology news

急性虚血性脳卒中における補助的静注アルガトロバンまたはエプチフィバチド投与：MOST無作為化臨床試験によるエビデンス

By MedXY 12/11/2025

Recent multi-site randomized evidence demonstrates that adding intravenous argatroban or eptifibatide to standard thrombolysis within 3 hours of stroke onset does not improve functional recovery and is associated with increased mortality, including in patients undergoing mechanical thrombectomy.

Neurology news Radiology

Baseline Penumbral Oxygen Extraction Fraction Predicts Infarct Growth Despite Successful Reperfusion

By MedXY 11/04/2025

In patients with anterior large‑vessel stroke who achieved successful reperfusion, lower penumbral oxygen extraction fraction (OEFr) on baseline DSC‑MRI independently predicted substantial infarct growth and greater penumbra-to-infarct conversion.

Emergency Medicine Neurology Rehabilitation Medicine Specialties

Evaluating Telestroke’s Impact on Acute Ischemic Stroke Treatment Timeliness and Outcomes

By MedXY 10/22/2025

Telestroke evaluation increases thrombolysis rates but is associated with longer treatment times and delays in patient transfers in acute ischemic stroke, highlighting the need to address modifiable treatment delays.

Clinical Updates Neurology

RNS60 as Adjunctive Therapy in Acute Large Vessel Occlusion Stroke: Insights from the RESCUE Trial

By MedXY 09/22/2025

The RESCUE trial demonstrates that RNS60, a novel oxygen-supersaturated saline solution, is safe and reduces infarct growth when added to endovascular thrombectomy in acute ischemic stroke due to large vessel occlusion, supporting further investigation in larger studies.

Neurology news Specialties

Extending the Therapeutic Window: Alteplase Use 4.5 to 24 Hours After Ischemic Stroke in the HOPE Trial

By MedXY 09/03/2025

The HOPE trial demonstrates that intravenous alteplase administered 4.5 to 24 hours after ischemic stroke onset improves functional independence in patients with salvageable brain tissue, despite increased risk of symptomatic intracranial hemorrhage.

Neurology news Radiology Specialties

Noncontrast CT vs CT Perfusion Imaging in Acute Stroke: Comparative Insights from Recent Trials and Systematic Review

By MedXY 08/17/2025

Recent evidence from randomized trials and meta-analyses suggests that noncontrast CT (NCCT) offers comparable outcome prediction to CT perfusion (CTP) for selecting patients with acute ischemic stroke, including basilar artery occlusion, for endovascular therapy (EVT).

Clinical Updates Neurology news Specialties

Edaravone Dexborneol in Acute Ischemic Stroke: Real-World Evidence of Enhanced Functional Recovery and Safety

By MedXY 08/17/2025

In a large multicenter cohort study, edaravone dexborneol treatment in acute ischemic stroke patients was linked to improved 90-day functional outcomes without increased adverse events, supporting its clinical utility.

Clinical Updates Neurology news Specialties

JAMA: Extending Intravenous Alteplase to 24 Hours in Imaging‑Selected Ischemic Stroke (HOPE Trial)

By MedXY 08/10/2025

The HOPE randomized trial shows that CT‑perfusion–selected patients treated with intravenous alteplase at 4.5–24 hours (no planned thrombectomy) had higher 90‑day functional independence (40.3% vs 26.3%), with increased symptomatic intracranial hemorrhage but no higher mortality.