Everolimus and Low-Dose Tacrolimus Therapy After Pediatric Heart Transplant: Insights from a Multicenter Randomized Clinical Trial
Posted inCardiology Pediatrics Specialties Transplantation

Everolimus and Low-Dose Tacrolimus Therapy After Pediatric Heart Transplant: Insights from a Multicenter Randomized Clinical Trial

This randomized trial evaluates the safety and efficacy of everolimus combined with low-dose tacrolimus versus standard immunosuppression in children 6 months post-heart transplant, highlighting comparable rejection rates, improved kidney function, and reduced CMV infection risk.
Smoothing the Leap to Adult Care: EU‑CAYAS‑NET Recommendations for Transition of Childhood and Adolescent Cancer Survivors
Posted innews Oncology Pediatrics

Smoothing the Leap to Adult Care: EU‑CAYAS‑NET Recommendations for Transition of Childhood and Adolescent Cancer Survivors

EU‑CAYAS‑NET issues 44 strong, evidence‑based recommendations to standardize and improve transitions from paediatric to adult survivorship care for those diagnosed with cancer at 0–21 years, emphasizing planned transfer, risk‑based follow‑up, care coordination, and patient‑centred supports.
Clinical Decision Tool Integrating Decision Tree, Point-of-Care CRP Testing, and Safety Netting to Optimize Antibiotic Use in Acutely Ill Children: Evidence from the ARON Pragmatic Trial and Contextual Literature
Posted inClinical Updates Critical Care news Pathology & Lab Medicine Pediatrics Public Health Specialties

Clinical Decision Tool Integrating Decision Tree, Point-of-Care CRP Testing, and Safety Netting to Optimize Antibiotic Use in Acutely Ill Children: Evidence from the ARON Pragmatic Trial and Contextual Literature

The ARON trial demonstrated that a clinical decision tool combining decision tree, point-of-care CRP testing, and safety-netting advice safely reduces antibiotic prescribing in acutely ill children without delaying recovery or increasing healthcare utilization.