Specialties – Page 53

Exploring the Therapeutic Potential of Betaine and Its Derivatives in Cancer Treatment: From Mechanisms to Clinical Implications

By MedXY 08/30/2025

Betaine, a natural methyl donor with antioxidant and anti-inflammatory properties, demonstrates promising anticancer activity across multiple cancer types. Its derivatives and nanotechnology-assisted delivery systems enhance therapeutic efficacy and safety, offering innovative avenues for cancer management.

Cardiology Diabetes & Endocrinology Nephrology Specialties

Flexovital Food Supplement Shows Promise in Mitigating Cardiovascular-Kidney-Metabolic Syndrome in Preclinical Model

By MedXY 08/30/2025

Flexovital, a nitric oxide-enhancing supplement, effectively attenuates metabolic, cardiovascular, and renal dysfunctions in a mouse model of cardiovascular-kidney-metabolic syndrome induced by unilateral nephrectomy and Western diet.

Clinical Updates Family Medicine & Nutrition news Specialties

Beetroot Juice and Physical Performance: Population-Specific Benefits and Optimal Supplementation Strategies

By MedXY 08/30/2025

Beetroot juice supplementation offers modest improvements in physical performance, enhancing muscular strength in professional athletes and aerobic endurance and lactate tolerance in healthy individuals. Acute dosing 2-3 hours pre-exercise with 8.3-16.4 mmol nitrate is optimal.

Family Medicine & Nutrition news Specialties

Enhancing Muscle Function in Older Adults: The Impact of Short-Term Dietary Nitrate Supplementation

By MedXY 08/30/2025

Short-term nitrate supplementation via beetroot juice improves muscle contractile properties and reduces fatigue in older adults, with no similar benefits observed in younger individuals.

Clinical Updates Family Medicine & Nutrition news OB/GYN & Women's Health Specialties

Enhancing Muscle Strength in Postmenopausal Women: Eight Weeks of Nitrate-Rich Beetroot Extract Supplementation Improves Muscle Function and Nitrate Bioavailability

By MedXY 08/30/2025

Eight weeks of nitrate-rich beetroot extract supplementation significantly increases fasting nitrate and nitrite levels, improving knee extensor muscle strength and power in postmenopausal women.

Cardiology Public Health Respiratory Specialties

Ventilation Hoods During Cooking Significantly Reduce PM2.5 Exposure and Improve Cardiometabolic and Pulmonary Health: Evidence from a Cluster-Randomized Trial in Rural China

By MedXY 08/30/2025

A community-based intervention using ventilation hoods during cooking reduced 24-hour PM2.5 exposure by nearly 30% and improved cardiometabolic and pulmonary health markers in rural Chinese villages reliant on wood fuel.

Clinical Updates Hematology-Oncology news Specialties

Novel Efficacy and Safety of Obinutuzumab Combined with Lenalidomide in First-Line Treatment of High Tumor Burden Follicular Lymphoma

By MedXY 08/30/2025

This phase 2 study demonstrates that obinutuzumab plus lenalidomide achieves high response rates with durable progression-free survival and manageable toxicities in untreated high tumor burden follicular lymphoma, suggesting a promising frontline option.

Cardiology Clinical Updates Family Medicine & Nutrition Internal Medicine news Specialties

Ageing, Oral Microbiome, and Vascular Health: How Dietary Nitrate Unlocks Cardiovascular Benefits

By MedXY 08/30/2025

Dietary nitrate supplementation alters age-related oral microbiome changes, enhancing nitric oxide bioavailability and reducing blood pressure in older adults, highlighting a novel mechanism for vascular health improvement.

Family Medicine & Nutrition

Time-Restricted Eating (16/8) Enhances Body Composition and Lipolytic Hormones in Female DanceSport Dancers Without Calorie Restriction

By MedXY 08/30/2025

A 6-week 16/8 time-restricted eating program improves fat loss and lipolytic hormone levels in female DanceSport athletes without altering calorie intake, highlighting a novel dietary timing strategy to optimize body composition and lipid metabolism.

Family Medicine & Nutrition Neurology Specialties

Low-Dose Caffeine Boosts Cognitive Function but Not Physical Performance in Fatigued Taekwondo Athletes: Insights from a Randomized Crossover Trial

By MedXY 08/30/2025

A 200 mg caffeine dose enhances cognitive processing by reducing brain fatigue markers without improving physical performance in fatigued Taekwondo athletes. The findings underscore caffeine's selective benefit on mental function over physical agility post-fatigue.

Clinical Updates Family Medicine & Nutrition Neurology news Specialties

A Caffeine and Theacrine Combination Enhances Cognitive Performance in Tactical Personnel Under Physical Fatigue

By MedXY 08/30/2025

Combining caffeine with theacrine improves cognitive and physical performance in tactical personnel during physically fatiguing conditions, offering benefits beyond caffeine alone and reducing common side effects.

Infectious Diseases Internal Medicine news Respiratory Specialties

Unraveling Mitochondrial Dysfunction as a Key Pathological Feature in Long COVID Syndrome

By MedXY 08/30/2025

Long COVID patients exhibit distinct mitochondrial bioenergetic impairments, with altered ATP synthase function correlating with clinical symptoms and quality of life, implicating mitochondrial dysfunction in its pathogenesis.

Clinical Updates Hematology-Oncology news Specialties

Optimizing Therapy in Transplant-Ineligible Multiple Myeloma: Insights from the REST Phase 2 Trial on Isatuximab, Bortezomib, Lenalidomide, and Limited Dexamethasone

By MedXY 08/30/2025

The REST trial demonstrated that combining isatuximab with weekly bortezomib, lenalidomide, and limited dexamethasone yields promising efficacy and manageable safety in older patients with transplant-ineligible multiple myeloma.

Respiratory Specialties

Decoding Fractional Exhaled Nitric Oxide (FeNO) Across the Lifespan: Establishing Normal Ranges in a Respiratory Healthy Population

By MedXY 08/30/2025

This study establishes reliable FeNO reference values throughout life in respiratory healthy individuals, highlighting factors that influence nitric oxide levels and enhancing asthma diagnosis and management.

Hematology-Oncology Specialties

ENHANCE-3 Trial: Evaluating Magrolimab Addition to Venetoclax and Azacitidine in Untreated AML Unfit for Intensive Chemotherapy

By MedXY 08/29/2025

The ENHANCE-3 phase 3 trial assessed whether adding magrolimab to venetoclax and azacitidine improves outcomes in untreated AML patients unfit for intensive chemotherapy, finding no survival benefit and a higher rate of fatal adverse events with magrolimab.

$Five-Year Outcomes of FCARH143: A Fully Human BCMA CAR-T Therapy in Relapsed/Refractory Multiple Myeloma$

Clinical Updates Hematology-Oncology Specialties

Five-Year Outcomes of FCARH143: A Fully Human BCMA CAR-T Therapy in Relapsed/Refractory Multiple Myeloma

By MedXY 08/29/2025

FCARH143, a fully human BCMA-directed CAR-T cell therapy, shows remarkable long-term efficacy and manageable safety profile in heavily pretreated relapsed/refractory multiple myeloma patients over 5 years.

Allergy & Immunology Hematology-Oncology Specialties

Clonal Hematopoiesis and Its Link to Severe Cytokine Release Syndrome in CAR T-Cell Therapy Recipients

By MedXY 08/29/2025

Clonal hematopoiesis (CH) occurs frequently in patients receiving CD19 or BCMA CAR T therapy and correlates with a higher risk of severe cytokine release syndrome (CRS), suggesting CH as a potential biomarker for CRS risk and a target for prophylactic strategies.

Hematology-Oncology Specialties

Tandem CD19/CD22 CAR T-Cell Therapy: A Promising Advance for High-Risk Pediatric and AYA r/r B-ALL

By MedXY 08/29/2025

Tandem CD19/CD22 CAR T-cell therapy shows encouraging safety and efficacy in heavily pretreated children and young adults with relapsed/refractory B-ALL, particularly when combined with consolidative hematopoietic stem cell transplantation.

Hematology-Oncology Specialties

Proinflammatory Cytokines and Low Peripheral Blood Counts Predict Poor Outcomes after CD19 CAR-T Therapy in Acute Lymphoblastic Leukemia

By MedXY 08/29/2025

Elevated proinflammatory cytokines combined with low peripheral blood counts early after CD19 CAR-T cell infusion correlate with poor treatment response and severe toxicity in relapsed/refractory B-ALL, highlighting inflammation as a key modifiable factor for improving outcomes.

Hematology-Oncology Specialties

T-ICAHT: A New Grading System for Thrombocytopenia After CAR T-cell Therapy with Prognostic Significance

By MedXY 08/29/2025

A novel grading system, T-ICAHT, quantifies thrombocytopenia after CAR T-cell therapy, revealing its prevalence and prognostic impact, highlighting its value in patient management and outcome prediction across hematologic malignancies.