Fertility-Preserving Hormonal Therapy vs Hysterectomy in Early-Stage Endometrial Cancer: Survival Outcomes and Clinical Implications
Posted innews OB/GYN & Women's Health Oncology Specialties

Fertility-Preserving Hormonal Therapy vs Hysterectomy in Early-Stage Endometrial Cancer: Survival Outcomes and Clinical Implications

This analysis compares survival in young women with early-stage endometrial cancer treated with fertility-preserving hormonal therapy versus hysterectomy, highlighting survival equivalence in women under 40 years and increased mortality risk in older patients undergoing hormonal therapy.
Precision Psychiatry Roadmap: Integrating Biology into Mental Disorder Classification and Treatment
Posted inClinical Updates news Psychiatry Specialties

Precision Psychiatry Roadmap: Integrating Biology into Mental Disorder Classification and Treatment

Mental disorders currently diagnosed symptomatically can be redefined using biology-informed frameworks integrating biological, behavioral, and environmental data. The Precision Psychiatry Roadmap aims to harmonize global research and clinical efforts to improve diagnostics and develop mechanism-based treatments.
Impact of Maternal Trace Element Levels on Neonatal Growth Among Diabetic and Non-Diabetic Pregnancies
Posted inDiabetes & Endocrinology news OB/GYN & Women's Health Specialties

Impact of Maternal Trace Element Levels on Neonatal Growth Among Diabetic and Non-Diabetic Pregnancies

A case–control study reveals that elevated copper levels in diabetic pregnant women negatively affect newborn weight and head circumference, while chromium correlates positively with birth length. Smoking exposure adversely impacts infants’ weight, underscoring maternal trace element status and lifestyle as key determinants of neonatal outcomes.
Tumor Microenvironment-Responsive Mn-Based Nanoplatform Activates cGAS-STING Pathway Coupled with Metabolic Interference for Enhanced Antitumor Therapy
Posted inAllergy & Immunology Clinical Updates news Oncology Specialties

Tumor Microenvironment-Responsive Mn-Based Nanoplatform Activates cGAS-STING Pathway Coupled with Metabolic Interference for Enhanced Antitumor Therapy

A novel Mn-based nanoplatform, LT@MnO@MON-HA (LMMH), responsive to tumor microenvironment triggers metabolic disruption and robust cGAS-STING activation, potentiating chemodynamic therapy and immunotherapy for improved tumor suppression.
Unraveling Chronic Stress: The Role of Gut Dysbiosis and Vitamin B6 Metabolism in Stress-Related Brain Disorders Independent of Cortisol
Posted inFamily Medicine & Nutrition Gastroenterology Psychiatry Public Health Specialties

Unraveling Chronic Stress: The Role of Gut Dysbiosis and Vitamin B6 Metabolism in Stress-Related Brain Disorders Independent of Cortisol

Recent evidence reveals gut dysbiosis-induced vitamin B6 metabolic disturbances as a novel, cortisol-independent mechanism driving chronic stress-related abnormal behaviors and inflammation, highlighting probiotic and vitamin B6 supplementation as potential therapeutic strategies.