Brensocatib Shows Imaging Signals of Structural Benefit in Non‑CF Bronchiectasis: CT Substudy from ASPEN Suggests Reduced Mucus Plugging and Modest Airway Change
Posted innews Respiratory

Brensocatib Shows Imaging Signals of Structural Benefit in Non‑CF Bronchiectasis: CT Substudy from ASPEN Suggests Reduced Mucus Plugging and Modest Airway Change

A 100‑patient CT substudy from the ASPEN program found that brensocatib, especially the 25‑mg dose, reduced mucus plugging and increased healthy parenchyma at 52 weeks, providing preliminary imaging evidence that it may modify disease biology in noncystic fibrosis bronchiectasis.
Wearables and Behaviour Change Work Best: Physical Activity Interventions After Hip and Knee Arthroplasty Improve Steps but Not Sedentary Time
Posted innews Orthopedics

Wearables and Behaviour Change Work Best: Physical Activity Interventions After Hip and Knee Arthroplasty Improve Steps but Not Sedentary Time

A meta-analysis of 23 RCTs (n≈1,265) found small but reliable increases in physical activity after hip or knee arthroplasty, driven by step-count gains and greater effects when interventions used wearable activity trackers, behaviour-change techniques, and were started early; effects on sedentary behaviour were uncertain.