Specialties – Page 26

Advanced Airway Devices and End-Tidal CO2 Trends in Cardiac Arrest: Insights from a Multicenter Randomized Trial

By MedXY 09/22/2025

This analysis compares end-tidal CO2 trends between laryngeal tube and endotracheal intubation in out-of-hospital cardiac arrest, revealing no significant difference in absolute values but highlighting complex interactions affecting return of spontaneous circulation outcomes.

Cardiology

Aspirin Versus Clopidogrel After Acute Coronary Syndrome: Insights from STOPDAPT-3 in High-Bleeding Risk and STEMI Patients

By MedXY 09/22/2025

STOPDAPT-3 trial shows aspirin and clopidogrel yield comparable cardiovascular and bleeding outcomes 1 month to 1 year post-PCI in ACS patients, regardless of bleeding risk or STEMI status.

Clinical Updates Emergency Medicine General Surgery news

Urgent Surgery Versus Fibrinolytic Therapy in Left-Sided Prosthetic Valve Thrombosis: Insights from a Groundbreaking Randomized Trial

By MedXY 09/22/2025

This first randomized trial comparing urgent surgery and fibrinolytic therapy (low-dose t-PA) for symptomatic left-sided prosthetic valve thrombosis finds similar efficacy but higher mortality with surgery and higher residual valve dysfunction with fibrinolysis.

Cardiology Clinical Updates news

Intravascular Imaging-Guided PCI vs CABG for Left Main or 3-Vessel Disease: Bridging the Outcome Gap

By MedXY 09/22/2025

Recent study shows intravascular imaging-guided PCI may offer comparable 3-year outcomes to CABG in patients with left main or 3-vessel coronary disease, challenging prior assumptions favoring surgery.

Clinical Updates Neurology news

Safety and Efficacy of Perispinal Etanercept for Chronic Stroke: A Comprehensive Review of Clinical Trial Evidence

By MedXY 09/22/2025

Perispinal etanercept is safe but does not improve quality of life in chronic stroke patients, as demonstrated by a Class I randomized trial; translational implications and future research directions are discussed.

Anesthesiology General Surgery news Specialties

Intensive vs Conventional Intraoperative Blood Pressure Management: Insights from the BP-CARES Trial on Cardiovascular Outcomes After Major Abdominal Surgery

By MedXY 09/22/2025

The BP-CARES randomized trial found no cardiovascular benefit of intensive intraoperative blood pressure management (MAP ≥80 mm Hg) over conventional targets in high-risk major abdominal surgery patients.

Clinical Updates Neurology news Ophthalmology

Evaluating Visual Scanning Training for Post-Stroke Homonymous Hemianopia: Insights from the SEARCH Trial

By MedXY 09/22/2025

The SEARCH trial investigated visual scanning training versus sham therapy in stroke survivors with homonymous hemianopia, finding no significant difference yet highlighting potential placebo and clinician-engagement effects, informing future rehabilitation approaches.

Cardiology Clinical Updates Neurology news Specialties

Impact of Hypertension History on the Efficacy of Clopidogrel-Aspirin Therapy in Ischemic Stroke Prevention

By MedXY 09/22/2025

This study investigates how a history of hypertension influences the effectiveness of combined clopidogrel-aspirin treatment in preventing recurrent strokes after mild ischemic events or high-risk transient ischemic attacks.

Clinical Updates Diabetes & Endocrinology Neurology news Specialties

Long-term Stroke Risk in Chinese Adults with Newly Diagnosed Diabetes and Impaired Glucose Tolerance: Insights from the 34-Year Da Qing Diabetes Study

By MedXY 09/22/2025

A 34-year follow-up of the Da Qing Diabetes Study reveals significantly increased stroke incidence among Chinese adults with newly diagnosed type 2 diabetes and impaired glucose tolerance, highlighting the beneficial impact of lifestyle intervention, particularly in women.

Cardiology Clinical Updates news Specialties

DIALIZE-Outcomes Trial: Sodium Zirconium Cyclosilicate Effect on Cardiovascular Outcomes in Hemodialysis Patients with Hyperkalemia

By MedXY 09/22/2025

The DIALIZE-Outcomes trial assessed sodium zirconium cyclosilicate (SZC) in controlling predialysis hyperkalemia among hemodialysis patients but found no reduction in arrhythmia-related cardiovascular events despite improved potassium control.

Cardiology Clinical Updates news Specialties

Rivaroxaban vs Warfarin in Postcardiac Surgery Atrial Fibrillation: Insights from the NEW-AF Trial

By MedXY 09/22/2025

The NEW-AF trial compared rivaroxaban and warfarin in new-onset atrial fibrillation after cardiac surgery, finding no difference in length of hospital stay but greater patient convenience and similar safety with rivaroxaban.

Clinical Updates Neurology news Nursing & care Specialties

Dissecting the Care Bundle: Mediation Analysis of Key Components Driving Improved Outcomes in INTERACT3 for Acute Intracerebral Hemorrhage

By MedXY 09/22/2025

Mediation analysis of INTERACT3 reveals that systolic blood pressure and blood glucose control are primary drivers of functional recovery benefits in acute intracerebral hemorrhage care bundles.

Clinical Updates news Public Health

Immunogenicity and Safety of the VLA15 Lyme Borreliosis Vaccine Across Age Groups: A Phase 2 Randomised Controlled Trial and Integrative Review

By MedXY 09/21/2025

This review synthesizes data on the VLA15 Lyme borreliosis vaccine candidate, demonstrating its safety and robust immunogenicity in adults, adolescents, and children, supporting multi-dose schedules and highlighting enhanced antibody responses in pediatric populations.

Respiratory Specialties

MACRO Trial Insights: Endoscopic Sinus Surgery Outperforms Clarithromycin in Chronic Rhinosinusitis Management

By MedXY 09/21/2025

The MACRO trial demonstrates that endoscopic sinus surgery significantly improves quality of life in adults with chronic rhinosinusitis, while long-term low-dose clarithromycin shows no added benefit over placebo.

Clinical Updates HIV/AIDS news Respiratory

Adjunctive Corticosteroids in Severe Pneumocystis jirovecii Pneumonia Among HIV-negative Patients: Insights from a Multicentre Randomised Trial

By MedXY 09/21/2025

A multicentre randomized trial evaluated adjunctive corticosteroids in HIV-negative severe Pneumocystis jirovecii pneumonia, showing a non-significant reduction in 28-day mortality and no safety concerns, and calls for further targeted research.

Clinical Updates Infectious Diseases news Respiratory Specialties

Evaluating BDLC Regimen in Pre-XDR Tuberculosis: Findings from the endTB-Q Phase 3 Trial

By MedXY 09/21/2025

The endTB-Q trial assessed the efficacy and safety of a shortened BDLC regimen versus WHO standard care in rifampicin-resistant and fluoroquinolone-resistant tuberculosis, finding BDLC non-inferior in mITT but overall not non-inferior, highlighting the need for longer, strengthened treatments.

Clinical Updates news Psychiatry

Theta Burst Stimulation of the Temporo-Parietal Cortex for Persistent Auditory Hallucinations in Schizophrenia: A Comprehensive Review of a Phase 3 Randomised Multicentre Trial and Contextual Evidence

By MedXY 09/21/2025

This review synthesizes evidence on bilateral continuous theta burst stimulation (cTBS) of the temporo-parietal cortex for persistent auditory verbal hallucinations (AVH) in schizophrenia, focusing on a landmark German phase 3 trial demonstrating safety and modest efficacy.

Clinical Updates Hematology-Oncology news Specialties

Oral Decitabine and Cedazuridine Maintenance Post-HSCT: Promising Strategy in High-Risk AML and MDS

By MedXY 09/21/2025

A phase 2 trial demonstrates that oral hypomethylating agent ASTX727, with optional donor lymphocyte infusion, shows encouraging disease-free survival and manageable safety after stem-cell transplantation in very high-risk acute myeloid leukaemia or myelodysplastic syndrome.

Clinical Updates Hematology-Oncology news

Oral Decitabine and Cedazuridine as Maintenance Therapy Post-HSCT in Very High-Risk AML and MDS: Insights from the GFM-DACORAL-DLI Phase 2 Trial

By MedXY 09/21/2025

A phase 2 trial demonstrates that oral decitabine and cedazuridine maintenance following hematopoietic stem-cell transplantation may improve disease-free survival in very high-risk AML and MDS patients with manageable safety.

$Enhancing Quality of Life in KRASG12C-Mutated Chemorefractory Metastatic Colorectal Cancer: Insights from the CodeBreaK 300 Phase 3 Trial$

news Oncology Specialties

Enhancing Quality of Life in KRASG12C-Mutated Chemorefractory Metastatic Colorectal Cancer: Insights from the CodeBreaK 300 Phase 3 Trial

By MedXY 09/21/2025

The phase 3 CodeBreaK 300 trial shows sotorasib plus panitumumab improves health-related quality of life and clinical outcomes in KRASG12C-mutated metastatic colorectal cancer compared to standard care.