Graded Sensorimotor Retraining for Chronic Low Back Pain: Clinical Efficacy and the Search for Treatment Responders
Posted inNeurology news Orthopedics

Graded Sensorimotor Retraining for Chronic Low Back Pain: Clinical Efficacy and the Search for Treatment Responders

The RESOLVE trial demonstrates that graded sensorimotor retraining provides modest pain relief for chronic low back pain. A secondary analysis reveals that these benefits are consistent across most patient subgroups, suggesting that the intervention is broadly applicable regardless of baseline psychological or physical factors.
Factor XI Inhibition Redefined: Catalytic Domain Blockade Emerges as a Superior Strategy for VTE Prevention
Posted inHematology-Oncology news Orthopedics

Factor XI Inhibition Redefined: Catalytic Domain Blockade Emerges as a Superior Strategy for VTE Prevention

The ROXI-VTE trials demonstrate that inhibiting the Factor XI catalytic domain significantly reduces postoperative VTE compared to enoxaparin. While blocking Factor XIIa-mediated activation showed promise, it failed to meet superiority, highlighting the critical role of Factor XI's catalytic activity in surgical thromboprophylaxis.
Cycling into Relief: The CLEAT Trial Validates Community-Based Exercise for Hip Osteoarthritis
Posted innews Orthopedics Rheumatology

Cycling into Relief: The CLEAT Trial Validates Community-Based Exercise for Hip Osteoarthritis

The CLEAT trial demonstrates that an 8-week cycling and education program (CHAIN) significantly improves function in hip osteoarthritis compared to usual physiotherapy. Despite falling just short of the clinical importance threshold, its high cost-effectiveness positions it as a viable community-based alternative for the NHS.
Biopsychosocial Self-Management Superior to Standard Care for Reducing Disability in Acute Back Pain: Insights from the PACBACK Trial
Posted inFamily Medicine & Nutrition news Orthopedics

Biopsychosocial Self-Management Superior to Standard Care for Reducing Disability in Acute Back Pain: Insights from the PACBACK Trial

The PACBACK randomized trial reveals that clinician-supported biopsychosocial self-management significantly reduces one-year disability in patients with acute low back pain at high risk of chronicity, whereas spinal manipulation alone offers no significant advantage over standard medical care.
Once-Weekly Navepegritide Raises Growth Velocity and Improves Skeletal and Functional Outcomes in Children with Achondroplasia: Results from the APPROACH Trial
Posted innews Orthopedics Pediatrics

Once-Weekly Navepegritide Raises Growth Velocity and Improves Skeletal and Functional Outcomes in Children with Achondroplasia: Results from the APPROACH Trial

The APPROACH randomized trial found once-weekly navepegritide significantly increased annualized growth velocity and produced favorable skeletal alignment and physical-function improvements in children with achondroplasia, with an acceptable short-term safety profile.
Ankle and Knee Dominance, Female Vulnerability, and Game-Time Risk: Contemporary Injury Incidence in Basketball Players
Posted innews Orthopedics Public Health

Ankle and Knee Dominance, Female Vulnerability, and Game-Time Risk: Contemporary Injury Incidence in Basketball Players

Systematic review and meta-analysis of 22 studies finds player contact and non-contact mechanisms dominate; ankle (25.8%) and knee (15.5%) injuries account for 41% of injuries. Females have higher rates of knee, concussion, and ball-contact injuries; injury rates are higher in games and at collegiate level.
Neuromuscular Training Substantially Improves Athletes’ Balance: A Meta-Analysis with Practical Takeaways
Posted inNeurology news Orthopedics Public Health

Neuromuscular Training Substantially Improves Athletes’ Balance: A Meta-Analysis with Practical Takeaways

A 2025 meta-analysis of 13 trials found neuromuscular training produced large improvements in athletes' balance (overall SMD 1.47), with benefits for both static and dynamic domains. Results support incorporating targeted neuromuscular programs into conditioning, while highlighting heterogeneity and research gaps.
Unraveling Hamstring Injury Mechanisms and Eccentric Training Adaptations: Integrative Insights and Future Preventive Strategies
Posted innews Orthopedics Rehabilitation Medicine

Unraveling Hamstring Injury Mechanisms and Eccentric Training Adaptations: Integrative Insights and Future Preventive Strategies

Hamstring injuries mainly occur during the late swing phase of running due to high eccentric forces and neural factors. Eccentric training reduces injury risk through complex muscle adaptations involving contractile, non-contractile, and neural components. Further research is essential to optimize prevention.