General Surgery – Page 2

Minimally Invasive Surgery for Left-Sided Pancreatic Cancer: Long-Term Safety Confirmed by DIPLOMA Trial

By MedXY 10/09/2025

The DIPLOMA trial demonstrates that minimally invasive left pancreatectomy for resectable pancreatic cancer offers comparable long-term survival outcomes to open surgery, validating its oncologic safety and supporting its use in clinical practice.

General Surgery news Oncology

Defining Cure in Stage II-III Colon Cancer: Insights from a Pooled Analysis of 15 Randomized Trials

By MedXY 10/04/2025

A rigorous pooled analysis of over 35,000 patients identifies a recurrence risk below 0.5% at 6 years post-surgery, providing a practical benchmark for defining cure in stage II-III colon cancer and refining patient management strategies.

Clinical Updates General Surgery news Specialties

Non-β-Lactam Antibiotics, β-Lactam Allergy, and Surgical Site Infections: Implications for Prophylaxis and Stewardship

By MedXY 10/01/2025

This study evaluates how reported β-lactam allergy and choice of prophylactic antibiotics impact surgical site infection rates, revealing non-β-lactam use increases SSI risk while allergy alone does not independently predict infections.

General Surgery Infectious Diseases Specialties

Optimizing Empiric Antibiotic Selection in Hospitalized Patients with Skin and Abdominal Infections: Insights from the INSPIRE 3 and 4 Cluster Randomized Clinical Trials

By MedXY 09/28/2025

The INSPIRE 3 and 4 trials demonstrate that computerized provider order entry (CPOE) prompts with patient-specific MDRO risk estimates, combined with education and feedback, significantly reduce empiric extended-spectrum antibiotic use in skin, soft tissue, and abdominal infections without compromising safety.

General Surgery

Cutting through the p-value: Assessing Clinical Relevance in Inguinal Hernia Repair Surgical Literature

By MedXY 09/28/2025

This analysis reveals pervasive underreporting of clinical relevance thresholds in studies comparing open, laparoscopic, and robotic inguinal hernia repairs, urging a shift beyond p-values to improve evidence-based surgical decisions.

Cardiology Clinical Updates General Surgery Pathology & Lab Medicine Specialties

Circulating Trimethylamine N-Oxide: A Novel Biomarker for Predicting Abdominal Aortic Aneurysm Progression and Surgical Risk

By MedXY 09/27/2025

Elevated plasma TMAO levels are associated with higher risk of abdominal aortic aneurysm development, rapid aneurysm growth, and need for surgical repair, providing a promising tool for risk stratification and personalized surveillance.

General Surgery Neurology news

Efficacy and Safety of Shunt Surgery in Idiopathic Normal-Pressure Hydrocephalus: Insights from a Rigorous Randomized Controlled Trial

By MedXY 09/27/2025

A double-blind, placebo-controlled trial demonstrates that shunt surgery significantly improves gait velocity and balance in patients with idiopathic normal-pressure hydrocephalus who respond to temporary CSF drainage, with mixed safety outcomes and no cognitive or urinary symptom benefits at 3 months.

Clinical Updates General Surgery Neurology news Specialties

Minimally Invasive Surgery versus Medical Management for Supratentorial Intracerebral Hemorrhage: Insights from the MIND Trial

By MedXY 09/26/2025

The MIND trial compared minimally invasive surgery using the Artemis device to standard medical management for supratentorial intracerebral hemorrhage, finding no significant improvement in 180-day functional outcomes or 30-day mortality with surgery.

General Surgery Neurology news Specialties

Minimally Invasive Surgery vs Medical Management in Supratentorial Intracerebral Hemorrhage: Insights from the MIND Randomized Trial

By MedXY 09/26/2025

The MIND trial found no significant functional benefit or mortality reduction with minimally invasive surgery compared to medical management alone in supratentorial intracerebral hemorrhage patients at 180 days.

General Surgery Neurology Specialties

Hyperbaric Oxygen Therapy Enhances Recovery After Intracranial Aneurysm Surgery

By MedXY 09/25/2025

A meta-analysis of 11 RCTs involving over 2000 patients shows hyperbaric oxygen therapy significantly improves neurologic function, independence, and quality of life post-intracranial aneurysm surgery.

Clinical Updates General Surgery news Transplantation

Combined Liver–Kidney Transplantation: Four Decades of Transformative Impact and Future Horizons

By MedXY 09/25/2025

Since the landmark combined liver–kidney transplant in 1984, advances in surgical techniques, immunosuppression, and donor allocation have revolutionized care for patients with dual organ failure. Emerging innovations, including gene-edited xenotransplantation, promise further breakthroughs.

General Surgery news Oncology Specialties

Optimizing Treatment Selection for Hepatocellular Carcinoma: Machine Learning Guidance in Choosing Liver Transplantation versus Surgical Resection

By MedXY 09/23/2025

A machine learning model accurately stratifies patients with hepatocellular carcinoma to guide individualized selection between liver transplantation and surgical resection, improving survival outcomes while addressing donor scarcity and patient heterogeneity.

Clinical Updates Emergency Medicine General Surgery news

Urgent Surgery Versus Fibrinolytic Therapy in Left-Sided Prosthetic Valve Thrombosis: Insights from a Groundbreaking Randomized Trial

By MedXY 09/22/2025

This first randomized trial comparing urgent surgery and fibrinolytic therapy (low-dose t-PA) for symptomatic left-sided prosthetic valve thrombosis finds similar efficacy but higher mortality with surgery and higher residual valve dysfunction with fibrinolysis.

Anesthesiology General Surgery news Specialties

Intensive vs Conventional Intraoperative Blood Pressure Management: Insights from the BP-CARES Trial on Cardiovascular Outcomes After Major Abdominal Surgery

By MedXY 09/22/2025

The BP-CARES randomized trial found no cardiovascular benefit of intensive intraoperative blood pressure management (MAP ≥80 mm Hg) over conventional targets in high-risk major abdominal surgery patients.

Clinical Updates General Surgery news Oncology Specialties

Innovative Combination of Cryoablation and Intratumoral Immunotherapy Extends Survival in Advanced Metastatic Cancer

By MedXY 09/21/2025

A phase II trial demonstrates that multiplex intratumoral immunotherapy combining cryoablation with low-dose immune checkpoint inhibitors significantly prolongs median overall survival to 20.9 months in treatment-refractory metastatic solid tumors.

General Surgery news Respiratory Specialties

Riociguat Continuation After Balloon Pulmonary Angioplasty Preserves Exercise Capacity in Inoperable CTEPH: Insights from the THERAPY-HYBRID-BPA Trial

By MedXY 09/19/2025

The THERAPY-HYBRID-BPA study demonstrates that continuing riociguat after balloon pulmonary angioplasty maintains exercise capacity in patients with inoperable chronic thromboembolic pulmonary hypertension without increasing adverse events.

Clinical Updates General Surgery Specialties

Reducing Delayed Hyponatremia After Endoscopic Transsphenoidal Surgery: The Role of Postoperative Fluid Restriction

By MedXY 09/17/2025

A prospective randomized study demonstrates that postoperative fluid restriction significantly reduces delayed hyponatremia and hospital readmission following endoscopic endonasal transsphenoidal surgery for pituitary tumors.

Anesthesiology General Surgery Oncology Specialties

Optimizing Anesthesia in Elderly NSCLC Patients: Impact of Midazolam and Dexmedetomidine Co-Administration on Hemodynamics and Stress Response

By MedXY 09/15/2025

Co-administering midazolam with dexmedetomidine in elderly NSCLC patients undergoing lobectomy enhances hemodynamic stability and reduces perioperative stress response, potentially improving recovery outcomes without increasing adverse events.

AI Clinical Updates General Surgery Specialties

Harnessing AI in Surgical Education: Deep Language Learning Model-Based Simulation Enhances Undergraduate History-Taking Skills

By MedXY 09/14/2025

A randomized controlled trial demonstrates that integrating deep language learning model (DLM) simulations into surgical training significantly improves history-taking skills and communication confidence among senior medical students.

General Surgery Specialties

Oral Corticosteroids Fail to Improve Recovery in Vocal Fold Paralysis After Thyroid Surgery: Insights from a Randomized Clinical Trial

By MedXY 09/13/2025

A randomized trial shows that a 7-day course of oral corticosteroids does not enhance vocal fold remobilization or voice quality in unilateral vocal fold paralysis following thyroid or parathyroid surgery, underscoring the continued importance of speech therapy.