Shared Genetic Vulnerability: Polygenic and Monogenic Contributions to Peripartum, Alcohol-Induced, and Cancer Therapy–Related Cardiomyopathies
Posted inCardiology news

Shared Genetic Vulnerability: Polygenic and Monogenic Contributions to Peripartum, Alcohol-Induced, and Cancer Therapy–Related Cardiomyopathies

A large multi-cohort genetic analysis shows that both rare monogenic variants and a high polygenic score for dilated cardiomyopathy (DCM) are enriched in peripartum, alcohol-induced, and cancer therapy–related cardiomyopathies, supporting a shared genetic susceptibility unmasked by diverse environmental stressors.
Common, Rare and Somatic Genetic Drivers Together Double 5‑Year Atrial Fibrillation Risk: Toward an Integrated Genomic Model (IGM‑AF)
Posted inCardiology news Pathology & Lab Medicine

Common, Rare and Somatic Genetic Drivers Together Double 5‑Year Atrial Fibrillation Risk: Toward an Integrated Genomic Model (IGM‑AF)

A UK Biobank whole‑genome study finds polygenic, rare monogenic, and somatic (CHIP) variants each independently associate with incident atrial fibrillation (AF); combined genomic profiling plus clinical risk (CHARGE‑AF) improves discrimination (C=0.80) and reclassification.
Intracardiac Echocardiography Is Noninferior to Transesophageal Echocardiography for Thrombus Screening in Atrial Fibrillation Ablation — with Added Safety and Efficiency Gains
Posted inCardiology news

Intracardiac Echocardiography Is Noninferior to Transesophageal Echocardiography for Thrombus Screening in Atrial Fibrillation Ablation — with Added Safety and Efficiency Gains

A multicenter randomized trial (N=1,810) found intracardiac echocardiography (ICE) noninferior to transesophageal echocardiography (TEE) for preventing periprocedural thromboembolism in AF ablation, while reducing bleeding related to transseptal puncture, fluoroscopy time, preprocedural wait, and patient anxiety.
Early Innate Microvascular Inflammation and Endothelial Activation Define the Xenoimmune Signature After Pig-to-Human Heart Transplantation
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Early Innate Microvascular Inflammation and Endothelial Activation Define the Xenoimmune Signature After Pig-to-Human Heart Transplantation

Multimodal analysis of two 10-gene–edited pig hearts transplanted into brain-dead human recipients revealed early innate microvascular inflammation with endothelial activation and a molecular profile consistent with antibody-mediated injury despite absent capillary C4d. A precision diagnostic approach may improve graft surveillance.
Elevated Blood Pressure in Adolescence Predicts Dose‑Dependent Coronary Atherosclerosis in Middle Age: Implications for Early Detection and Prevention
Posted inCardiology news Pediatrics Public Health

Elevated Blood Pressure in Adolescence Predicts Dose‑Dependent Coronary Atherosclerosis in Middle Age: Implications for Early Detection and Prevention

A Swedish cohort study of 10,222 men linked adolescent blood pressure to coronary atherosclerosis by CCTA ~40 years later; higher systolic BP in adolescence, even in the ‘elevated’ range, was associated with greater odds of severe (>50%) coronary stenosis in middle age.
Underweight in Type 2 Diabetes Raises Cardiovascular Risk — Severe Leanness Carries Greater Risk Than Obesity
Posted inCardiology Diabetes & Endocrinology news

Underweight in Type 2 Diabetes Raises Cardiovascular Risk — Severe Leanness Carries Greater Risk Than Obesity

A nationwide Korean cohort found that underweight patients with Type 2 diabetes—especially those with severe underweight—have higher cardiovascular risk than normal-weight and even some obese patients, underscoring the need to screen and manage malnutrition, sarcopenia, and frailty in diabetes care.
Excessive Glycosylation and the HBP–ISR Axis: A Metabolic Driver of Thoracic Aortic Aneurysm with Therapeutic Implications
Posted inCardiology news

Excessive Glycosylation and the HBP–ISR Axis: A Metabolic Driver of Thoracic Aortic Aneurysm with Therapeutic Implications

A preclinical and human tissue study shows up-regulation of the hexosamine biosynthetic pathway and downstream integrated stress response in thoracic aortic aneurysm, linking excessive glycosylation to vascular smooth muscle cell dysfunction and medial degeneration; pharmacologic inhibition reverses disease features in a Marfan model.
METTL14 and LATS1/2 Define Divergent Endothelial Programs That Drive Vascular Ageing and Atherothrombosis — New Therapeutic Nodes in Cardio‑Vascular Senescence
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METTL14 and LATS1/2 Define Divergent Endothelial Programs That Drive Vascular Ageing and Atherothrombosis — New Therapeutic Nodes in Cardio‑Vascular Senescence

Two complementary studies identify METTL14/TLR4 and LATS1/2–CD38–SUOX axes as key drivers of endothelial senescence phenotypes that promote arterial ageing, stiffness, fragile neovessels and atherothrombotic plaque formation, highlighting new biomarker and therapeutic opportunities.
Normalising Renin After Medical Therapy for Primary Aldosteronism May Lower Cardiovascular Risk — But RCTs Are Needed
Posted inCardiology Diabetes & Endocrinology news

Normalising Renin After Medical Therapy for Primary Aldosteronism May Lower Cardiovascular Risk — But RCTs Are Needed

A 2025 systematic review and meta-analysis found that patients with primary aldosteronism whose renin rose after mineralocorticoid receptor antagonist therapy had substantially lower cardiovascular event rates and possibly lower mortality, suggesting renin normalisation as a therapeutic target pending prospective confirmation.