Medxy AI – Page 79

Reevaluating Early Blood Pressure Targets in Acute Spinal Cord Injury: Insights from a Multicenter Randomized Trial

By MedXY 09/20/2025

A recent randomized clinical trial comparing augmented to conventional blood pressure targets in acute spinal cord injury found no improvement in 6-month neurological outcomes, challenging current practices and highlighting risks of higher blood pressure management.

Clinical Updates Internal Medicine OB/GYN & Women's Health Specialties

Evaluating Low-Dose Aspirin for Postpartum Venous Thromboembolism Prevention: Insights from the Pilot PARTUM Trial

By MedXY 09/20/2025

The pilot PARTUM trial demonstrates the feasibility of a large-scale multi-national randomized study assessing low-dose aspirin versus placebo for postpartum venous thromboembolism prevention in moderate-risk individuals, supporting further investigation.

Clinical Updates news OB/GYN & Women's Health Specialties

Certolizumab Pegol Shows Promise in Reducing Adverse Pregnancy Outcomes in High-Risk APS Patients: Insights from the IMPACT Trial

By MedXY 09/19/2025

The IMPACT trial demonstrates that adding certolizumab pegol to standard therapy reduces placenta-mediated adverse pregnancy outcomes in women with antiphospholipid syndrome and lupus anticoagulant, with favorable safety and neonatal outcomes.

Clinical Updates news OB/GYN & Women's Health Specialties

Aspirin for Delaying Preterm Birth in High-Risk Preterm Pre-eclampsia Pregnancies: Insights from a Multicenter Randomized Trial in Asia

By MedXY 09/19/2025

Early low-dose aspirin reduces early preterm birth risk and delays timing of delivery in women at high risk for preterm pre-eclampsia, with significant benefits in iatrogenic preterm births and small-for-gestational-age pregnancies.

Clinical Updates Oncology

Adjuvant Aspirin in PIK3CA-Mutated Colon Cancer: Insights from the SAKK 41/13 Randomized Trial

By MedXY 09/19/2025

The SAKK 41/13 trial provides the first prospective randomized evidence that adjuvant aspirin may improve disease-free survival in patients with resected PIK3CA-mutated stage II and III colon cancer, suggesting its potential as a safe, cost-effective adjuvant strategy.

Clinical Updates Critical Care news Specialties

Proportional-Assist Ventilation vs. Pressure-Support Ventilation: Implications for Liberation from Mechanical Ventilation

By MedXY 09/19/2025

An international trial comparing proportional-assist ventilation (PAV+) with pressure-support ventilation (PSV) showed no significant difference in time to successful liberation from mechanical ventilation among critically ill adults.

Clinical Updates news Oncology Specialties

Low-Dose Aspirin’s Impact on PI3K-Altered Localized Colorectal Cancer: New Evidence from a Randomized Controlled Trial

By MedXY 09/19/2025

This randomized trial confirms that daily low-dose aspirin significantly reduces colorectal cancer recurrence in patients with PI3K pathway mutations, highlighting a targeted adjunctive therapy option.

Clinical Updates Critical Care Specialties

Proportional-Assist Ventilation and Pressure-Support Ventilation: Comparative Impact on Mechanical Ventilation Duration in Critical Care

By MedXY 09/19/2025

A comprehensive international trial showed that proportional-assist ventilation (PAV+) does not significantly shorten the time to liberation from mechanical ventilation compared to pressure-support ventilation (PSV) in critically ill adults, with comparable safety and secondary outcomes.

news Respiratory

Mepolizumab in Preventing COPD Exacerbations in Patients with Eosinophilic Phenotype: Insights from the MATINEE Trial

By MedXY 09/19/2025

Mepolizumab significantly reduces moderate to severe COPD exacerbations in patients with elevated eosinophils on triple inhaled therapy, marking a promising advance for eosinophilic COPD management.

news Respiratory Specialties

High-Flow Nasal Oxygen Reduces Hypoxaemia During Bronchoscopy in COPD: Insights from the PROSA 2 Randomised Trial

By MedXY 09/19/2025

The PROSA 2 trial demonstrates that high-flow nasal oxygen significantly reduces hypoxaemia time and events compared to conventional low-flow oxygen in COPD patients undergoing bronchoscopy, improving procedural safety without compromising patient comfort.

news Respiratory Specialties

Decoding COPD Heterogeneity: Airway Eosinophilia, Type 2 Inflammation, and Corticosteroid Responsiveness

By MedXY 09/19/2025

This study elucidates that airway eosinophilia in COPD is linked to enhanced type 2 inflammation in airway epithelium and predicts responsiveness to inhaled corticosteroids, revealing a distinct COPD endotype with potential for precision therapy.

Family Medicine & Nutrition Medical News news Specialties Urology

How Often Should Men Have Sex? Harvard Study Links 21 Times a Month to Lower Prostate Cancer Risk

By MedXY 09/19/2025

A large Harvard study finds that frequent ejaculation—about 21 times a month—is associated with a significantly reduced risk of prostate cancer among men, offering new insights into modifiable factors for prevention.

AI Family Medicine & Nutrition Medical News news Specialties

Delphi-2M: The AI That Predicts Your Health 20 Years Ahead

By MedXY 09/19/2025

A new AI model, Delphi-2M, predicts the risk of over 1,000 diseases up to 20 years in the future with remarkable accuracy, transforming disease prevention and personalized health management.

Clinical Updates news Respiratory

Low-Dose Morphine in COPD: Balancing Breathlessness Relief Against Sleep-Related Respiratory Risks

By MedXY 09/19/2025

A randomized crossover trial reveals low-dose morphine in COPD does not improve sleep efficiency or breathlessness but may cause nocturnal hypoventilation, raising safety concerns despite unchanged next-day alertness.

Clinical Updates news Respiratory

Dupilumab Enhances Quality of Life and Relieves Respiratory Symptoms in COPD Patients with Type 2 Inflammation: Insights from BOREAS and NOTUS Trials

By MedXY 09/19/2025

Add-on dupilumab significantly improves health-related quality of life and respiratory symptoms in COPD patients with type 2 inflammation, according to pooled results from the BOREAS and NOTUS phase 3 trials.

Clinical Updates news Respiratory Specialties

Sustained Alterations in Glutamate Metabolism After Resistance Exercise in Older Adults With COPD and Healthy Controls

By MedXY 09/19/2025

Resistance exercise induces prolonged increases in glutamate production in older adults with COPD and healthy controls, highlighting unique metabolic adaptations that may influence pulmonary rehabilitation outcomes and muscle health.

Clinical Updates news

Innovative Airway Scaffolds Demonstrate Safety and Efficacy in Reducing Hyperinflation in Severe Emphysema: Six-Month BREATHE Trial Results

By MedXY 09/19/2025

The BREATHE trial reveals that novel self-expanding nitinol airway scaffolds are safe, feasible, and effective in reducing lung hyperinflation and improving symptoms in severe emphysema patients at six months post-implantation.

news Respiratory Specialties

Targeting IL-33 in COPD: Insights from the Phase 2a FRONTIER-4 Trial of Tozorakimab

By MedXY 09/19/2025

The FRONTIER-4 phase 2a trial evaluated tozorakimab, an anti-IL-33 monoclonal antibody, in moderate-to-severe COPD with chronic bronchitis. While the primary endpoint was unmet in the overall population, efficacy signals emerged in patients with frequent exacerbations, supporting ongoing phase 3 studies.

news Respiratory Specialties

Decoding Thoracoabdominal Asynchrony in Severe COPD: Insights Into Exercise Limitation and Respiratory Support

By MedXY 09/19/2025

This study reveals how thoracoabdominal asynchrony (TAA) during exercise reflects lung function severity and predicts breathlessness in very severe COPD patients, highlighting its potential to guide personalized respiratory support strategies during rehabilitation.

Clinical Updates news Respiratory

Enhancing Home Non-Invasive Ventilation Outcomes Through Real-World Telemonitoring: Insights from the eVENT Randomised Study

By MedXY 09/19/2025

The eVENT study demonstrates that telemonitoring combined with remote support significantly improves arterial CO2 control and home NIV adherence compared to usual care, highlighting a promising approach to optimize chronic respiratory failure management.

Reevaluating Early Blood Pressure Targets in Acute Spinal Cord Injury: Insights from a Multicenter Randomized Trial

Evaluating Low-Dose Aspirin for Postpartum Venous Thromboembolism Prevention: Insights from the Pilot PARTUM Trial

Certolizumab Pegol Shows Promise in Reducing Adverse Pregnancy Outcomes in High-Risk APS Patients: Insights from the IMPACT Trial

Aspirin for Delaying Preterm Birth in High-Risk Preterm Pre-eclampsia Pregnancies: Insights from a Multicenter Randomized Trial in Asia

Adjuvant Aspirin in PIK3CA-Mutated Colon Cancer: Insights from the SAKK 41/13 Randomized Trial

Proportional-Assist Ventilation vs. Pressure-Support Ventilation: Implications for Liberation from Mechanical Ventilation

Low-Dose Aspirin’s Impact on PI3K-Altered Localized Colorectal Cancer: New Evidence from a Randomized Controlled Trial

Proportional-Assist Ventilation and Pressure-Support Ventilation: Comparative Impact on Mechanical Ventilation Duration in Critical Care

Mepolizumab in Preventing COPD Exacerbations in Patients with Eosinophilic Phenotype: Insights from the MATINEE Trial

High-Flow Nasal Oxygen Reduces Hypoxaemia During Bronchoscopy in COPD: Insights from the PROSA 2 Randomised Trial

Decoding COPD Heterogeneity: Airway Eosinophilia, Type 2 Inflammation, and Corticosteroid Responsiveness

How Often Should Men Have Sex? Harvard Study Links 21 Times a Month to Lower Prostate Cancer Risk

Delphi-2M: The AI That Predicts Your Health 20 Years Ahead

Low-Dose Morphine in COPD: Balancing Breathlessness Relief Against Sleep-Related Respiratory Risks

Dupilumab Enhances Quality of Life and Relieves Respiratory Symptoms in COPD Patients with Type 2 Inflammation: Insights from BOREAS and NOTUS Trials

Sustained Alterations in Glutamate Metabolism After Resistance Exercise in Older Adults With COPD and Healthy Controls

Innovative Airway Scaffolds Demonstrate Safety and Efficacy in Reducing Hyperinflation in Severe Emphysema: Six-Month BREATHE Trial Results

Targeting IL-33 in COPD: Insights from the Phase 2a FRONTIER-4 Trial of Tozorakimab

Decoding Thoracoabdominal Asynchrony in Severe COPD: Insights Into Exercise Limitation and Respiratory Support

Enhancing Home Non-Invasive Ventilation Outcomes Through Real-World Telemonitoring: Insights from the eVENT Randomised Study

The SEIZURE Score Faces Global Challenges: International Validation Highlights Geographic Disparities in Predicting Encephalitis Seizures

Precision Base-Editing and Universal CAR7 T Cells: Transforming the Treatment Landscape for Refractory T-Cell Acute Lymphoblastic Leukemia

Short-Course Ianalumab Combined with Eltrombopag: A Potential Shift Toward Sustained Remission in Immune Thrombocytopenia

B-Cell Depletion Meets TPO-RA: Ianalumab and Eltrombopag Redefine Treatment Success in Immune Thrombocytopenia