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FDA Fast-Tracks Rezpegaldesleukin for Severe Alopecia Areata: Promise for a Challenging Disease
Posted inClinical Updates Wellness & Lifestyle

FDA Fast-Tracks Rezpegaldesleukin for Severe Alopecia Areata: Promise for a Challenging Disease

Posted by By MedXY 07/30/2025
The FDA has granted Fast Track status to rezpegaldesleukin (REZPEG), a novel biologic targeting regulatory T cells, for severe-to-very severe alopecia areata in patients aged ≥12 years. Phase 2b trial results are anticipated in December 2025.
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How to Make Urology Care More Comfortable for Women
Posted inWellness & Lifestyle

How to Make Urology Care More Comfortable for Women

Posted by By MedXY 07/30/2025
Exploring why women often feel discomfort during urology visits and actionable strategies to create a more welcoming, effective clinical experience.
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GLP-1 Receptor Agonists Linked to Early Risk of Optic Nerve Damage: A Case-Control Study Analysis
Posted inClinical Updates Wellness & Lifestyle

GLP-1 Receptor Agonists Linked to Early Risk of Optic Nerve Damage: A Case-Control Study Analysis

Posted by By MedXY 07/30/2025
GLP-1 receptor agonist use, especially liraglutide, is associated with a higher risk of nonarteritic anterior ischemic optic neuropathy (NAION) during the first year, particularly in patients without diabetes or obesity.
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Top U.S. Hospitals for Gastroenterology and GI Surgery: 2025-2026 Rankings and Clinical Implications
Posted inMedical News Wellness & Lifestyle

Top U.S. Hospitals for Gastroenterology and GI Surgery: 2025-2026 Rankings and Clinical Implications

Posted by By MedXY 07/30/2025
Mayo Clinic leads U.S. News' 2025-2026 rankings for gastroenterology and GI surgery, reflecting excellence in outcomes, capabilities, and research. This review examines the clinical context, ranking methodology, and relevance for clinicians and patients.
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Walking and Dietary Interventions Offer Cognitive Protection in APOE ε4 Carriers: New Evidence from Longitudinal and Multinational Trials
Posted inClinical Updates Wellness & Lifestyle

Walking and Dietary Interventions Offer Cognitive Protection in APOE ε4 Carriers: New Evidence from Longitudinal and Multinational Trials

Posted by By MedXY 07/30/2025
Regular walking and lifestyle interventions slow cognitive decline, especially in APOE ε4 carriers at heightened Alzheimer’s risk, with effects pronounced in women. Evidence underscores the value of simple activity and healthy diet for at-risk older adults.
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Personal and Household Pesticide Exposure Linked to Increased Risk of Rheumatoid Arthritis in Female Farm Spouses
Posted inClinical Updates Wellness & Lifestyle

Personal and Household Pesticide Exposure Linked to Increased Risk of Rheumatoid Arthritis in Female Farm Spouses

Posted by By MedXY 07/30/2025
New evidence links direct and indirect exposure to specific agricultural pesticides with increased risk of incident rheumatoid arthritis among female spouses of licensed pesticide applicators.
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Top U.S. Hospitals for Diabetes and Endocrinology: Interpreting the 2025–2026 U.S. News Rankings
Posted inMedical News Wellness & Lifestyle

Top U.S. Hospitals for Diabetes and Endocrinology: Interpreting the 2025–2026 U.S. News Rankings

Posted by By MedXY 07/30/2025
A critical analysis of the 2025–2026 U.S. News rankings for diabetes and endocrinology care, examining methodology, clinical impact, and implications for patient care and referral.
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Cockroach Immunotherapy Modulates Key T-Cell Responses Regardless of Allergen Extract Abundance
Posted inClinical Updates Wellness & Lifestyle

Cockroach Immunotherapy Modulates Key T-Cell Responses Regardless of Allergen Extract Abundance

Posted by By MedXY 07/30/2025
A randomized trial finds that subcutaneous cockroach immunotherapy effectively downregulates dominant T-cell responses in pediatric asthma, independent of allergen abundance in the therapeutic extract.
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Muscle Strength as a Key Determinant of Metabolic Risk in Paediatric Obesity: New Evidence from Milan
Posted inClinical Updates Wellness & Lifestyle

Muscle Strength as a Key Determinant of Metabolic Risk in Paediatric Obesity: New Evidence from Milan

Posted by By MedXY 07/30/2025
Stronger leg muscles are linked to significantly lower risk of metabolic syndrome in children and adolescents with obesity, highlighting the importance of muscular fitness in paediatric metabolic health.
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Evolving Patterns in Antiseizure Drug Use During Pregnancy: Safer Choices and New Uncertainties
Posted inClinical Updates Wellness & Lifestyle

Evolving Patterns in Antiseizure Drug Use During Pregnancy: Safer Choices and New Uncertainties

Posted by By MedXY 07/30/2025
A decade-long French study reveals declining prenatal exposure to high-risk antiseizure drugs, increased use of safer alternatives, and a notable rise in prescriptions for newer drugs with uncertain safety profiles.
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Digital Self-Management Tools Enhance Asthma Control
Posted inClinical Updates Wellness & Lifestyle

Digital Self-Management Tools Enhance Asthma Control

Posted by By MedXY 07/30/2025
A randomized trial shows that a smartphone-based asthma self-management program improves symptom control in adults, though its effectiveness is attenuated in African American participants.
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Redefining Obesity: Impact of the ‘Clinical Obesity’ Framework on Global Prevalence Estimates
Posted inMedical News Wellness & Lifestyle

Redefining Obesity: Impact of the ‘Clinical Obesity’ Framework on Global Prevalence Estimates

Posted by By MedXY 07/30/2025
A new, function-driven definition of “clinical obesity” dramatically lowers global obesity prevalence rates compared to BMI-based estimates, raising implications for disease surveillance, prevention, and healthcare policy.
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Opioid Prescribing Down, Imaging Steady: Patterns in US ED Management of Low Back Pain, 2016–2022
Posted inClinical Updates Wellness & Lifestyle

Opioid Prescribing Down, Imaging Steady: Patterns in US ED Management of Low Back Pain, 2016–2022

Posted by By MedXY 07/30/2025
A large national study shows opioid prescribing for ED low back pain fell sharply from 2016 to 2022, while radiograph use remained high and unchanged.
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Rising Threat: Triazole-Resistant Aspergillus fumigatus and the Challenge of Fungal Antimicrobial Resistance
Posted inClinical Updates Wellness & Lifestyle

Rising Threat: Triazole-Resistant Aspergillus fumigatus and the Challenge of Fungal Antimicrobial Resistance

Posted by By MedXY 07/30/2025
A 29-year genomic study reveals increasing genetic diversity and prevalence of triazole-resistant Aspergillus fumigatus, raising concerns for clinical management and highlighting the need for novel diagnostics and antifungal strategies.
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Novel HIV Peptides Identified During Treatment Interruption May Inform Next-Generation Therapeutic Strategies
Posted inClinical Updates Wellness & Lifestyle

Novel HIV Peptides Identified During Treatment Interruption May Inform Next-Generation Therapeutic Strategies

Posted by By MedXY 07/30/2025
Discovery of genetically conserved, mutation-intolerant HIV peptides in rebound virus during analytic treatment interruption highlights new avenues for mRNA vaccine development and functional HIV cure strategies.
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US News & World Report 2025-2026 Rankings: The Top US Psychiatric Hospitals and Their Clinical Impact
Posted inMedical News Wellness & Lifestyle

US News & World Report 2025-2026 Rankings: The Top US Psychiatric Hospitals and Their Clinical Impact

Posted by By MedXY 07/30/2025
Massachusetts General Hospital leads the 2025-2026 US News psychiatric hospital rankings. Rankings highlight excellence in psychiatric care, but methodological nuances and clinical implications warrant closer examination.
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Managing Chronic Kidney Disease-Associated Pruritus: Advances and Clinical Strategies
Posted inClinical Updates Medical News

Managing Chronic Kidney Disease-Associated Pruritus: Advances and Clinical Strategies

Posted by By MedXY 07/30/2025
CKD-associated pruritus affects up to 85% of dialysis patients and significantly impairs quality of life. Stepwise management, including novel therapies like nemolizumab, is essential for effective symptom control and improved patient outcomes.
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Elevated Colorectal Cancer Risk in Patients with IBD and Primary Sclerosing Cholangitis: Insights from a National Swedish Cohort
Posted inClinical Updates Wellness & Lifestyle

Elevated Colorectal Cancer Risk in Patients with IBD and Primary Sclerosing Cholangitis: Insights from a National Swedish Cohort

Posted by By MedXY 07/30/2025
Patients with inflammatory bowel disease (IBD), particularly those with primary sclerosing cholangitis (PSC) or early-onset disease, face a substantially increased risk of colorectal cancer (CRC), emphasizing the need for vigilant surveillance.
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Alcohol and Pancreatic Cancer: Emerging Evidence of Risk
Posted inWellness & Lifestyle

Alcohol and Pancreatic Cancer: Emerging Evidence of Risk

Posted by By MedXY 07/30/2025
New research strengthens the link between alcohol consumption and pancreatic cancer, highlighting both dose-dependent and threshold risks.
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Antibody-Drug Conjugates in Breast Cancer: Efficacy, Toxicity, and Evolving Management Strategies
Posted inClinical Updates Wellness & Lifestyle

Antibody-Drug Conjugates in Breast Cancer: Efficacy, Toxicity, and Evolving Management Strategies

Posted by By MedXY 07/30/2025
Antibody-drug conjugates (ADCs) have transformed breast cancer therapy but bring notable toxicity risks. This review examines the clinical evidence, adverse event management, and future directions for optimizing ADC use.
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  • Immunogenicity and Safety of the VLA15 Lyme Borreliosis Vaccine Across Age Groups: A Phase 2 Randomised Controlled Trial and Integrative Review
  • MACRO Trial Insights: Endoscopic Sinus Surgery Outperforms Clarithromycin in Chronic Rhinosinusitis Management
  • Adjunctive Corticosteroids in Severe Pneumocystis jirovecii Pneumonia Among HIV-negative Patients: Insights from a Multicentre Randomised Trial
  • Evaluating BDLC Regimen in Pre-XDR Tuberculosis: Findings from the endTB-Q Phase 3 Trial
  • Theta Burst Stimulation of the Temporo-Parietal Cortex for Persistent Auditory Hallucinations in Schizophrenia: A Comprehensive Review of a Phase 3 Randomised Multicentre Trial and Contextual Evidence
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