Medxy AI

Understanding Adult Responses to Cannabis Health Warnings in US Recreational States: Insights from the EPPM Model

By MedXY 07/30/2025

A recent study reveals that most adults in US recreational states respond maladaptively to cannabis health warnings, highlighting challenges and opportunities for improved public health messaging.

Clinical Updates Wellness & Lifestyle

Long-Term Fracture Risk After Menopausal Hormone Therapy: New Insights from a Landmark Study

By MedXY 07/30/2025

Large-scale UK data reveal a transient increase but sustained long-term reduction in fracture risk after discontinuing menopausal HRT, challenging prior assumptions and guiding future clinical decisions.

Clinical Updates Wellness & Lifestyle

JAK Inhibitors and Venous Thromboembolism in Atopic Dermatitis: Clinical Risks and Practice Implications

By MedXY 07/30/2025

JAK inhibitors significantly increase the risk of venous thromboembolism compared to dupilumab and methotrexate in atopic dermatitis, underscoring the need for individualized risk stratification.

Clinical Updates

High Tibial Osteotomy May Slow Knee Osteoarthritis Progression in Bowlegged Patients: Clinical Insights from a Randomized Trial

By MedXY 07/30/2025

High tibial osteotomy (HTO) slows cartilage loss and improves pain and function in bowlegged patients with medial knee osteoarthritis compared to nonsurgical management, according to a new randomized trial.

Medical News

FDA Approves Sephience: A New Oral Therapy for Phenylketonuria

By MedXY 07/30/2025

The FDA has approved Sephience, an oral therapy for phenylketonuria (PKU), offering a novel treatment option for both children and adults with this rare metabolic disorder.

Clinical Updates Wellness & Lifestyle

EMA Recommends First Oral On-Demand Therapy for Hereditary Angioedema: A Paradigm Shift in Acute Attack Management

By MedXY 07/30/2025

EMA endorses sebetralstat, the first oral on-demand therapy for hereditary angioedema, following positive results from the KONFIDENT phase 3 trial, offering a more convenient and rapid treatment option for acute attacks.

Clinical Updates Wellness & Lifestyle

EMA Recommends Voranigo for IDH-Mutant Grade 2 Glioma: A New Era in Targeted Brain Tumor Therapy

By MedXY 07/30/2025

The EMA’s CHMP recommends Voranigo, a dual IDH1/2 inhibitor, for grade 2 IDH-mutant gliomas, based on phase 3 INDIGO trial results demonstrating significant improvement in progression-free survival and delayed need for further therapy.

Clinical Updates Wellness & Lifestyle

Parathyroidectomy Enhances Muscle Health in Postmenopausal Women with Primary Hyperparathyroidism

By MedXY 07/30/2025

Surgical treatment of primary hyperparathyroidism in postmenopausal women significantly improves muscle strength, volume, and metabolic pathways linked to exercise, without increased physical activity.

Clinical Updates Wellness & Lifestyle

Unraveling the Drivers of Pruritus Severity in Intrahepatic Cholestasis of Pregnancy: Insights from a Longitudinal Cohort Study

By MedXY 07/30/2025

Peak bile acid levels and higher maternal BMI independently predict pruritus worsening in intrahepatic cholestasis of pregnancy, emphasizing the need for tailored monitoring and management as gestation advances.

Clinical Updates Wellness & Lifestyle

Early Postoperative PTH as a Reliable Predictor of Hypoparathyroidism After Total Thyroidectomy

By MedXY 07/30/2025

A single parathyroid hormone (PTH) measurement 6 hours after total thyroidectomy can accurately predict the risk of transient and permanent hypoparathyroidism, enabling targeted monitoring and potential reduction in hospital stays.

Medical News Wellness & Lifestyle

Legacy of Leaded Gasoline: New Evidence Links Childhood and Adult Exposure to Cognitive Impairment in Older Adults

By MedXY 07/30/2025

Recent studies confirm that both childhood and adult lead exposure, especially from gasoline and industrial sources, are associated with increased risk for cognitive decline and dementia in later life.

Medical News Wellness & Lifestyle

CDC Retracts Universal COVID-19 Vaccination Recommendation for Pregnancy: Clinical Context, Evidence, and Implications

By MedXY 07/30/2025

The CDC no longer universally recommends COVID-19 vaccination during pregnancy, prompting debate among clinicians as the FDA shifts vaccine composition to target the JN.1 variant. This article analyzes the evidence, rationale, and clinical implications.

Medical News Wellness & Lifestyle

Is There a Norovirus Vaccine on the Horizon? Scientific Progress, Challenges, and Future Directions

By MedXY 07/30/2025

Norovirus vaccines show promise in clinical trials, but scientific and logistical challenges remain. No approved vaccine exists yet, though novel approaches, including oral pills, are advancing development.

Clinical Updates Wellness & Lifestyle

Expanding Access to Chronic Pain Care: Telehealth and Online CBT-Based Interventions Show Promise

By MedXY 07/30/2025

Remote CBT-based interventions, delivered by telehealth or online modules, offer modest but significant improvements in pain and function for individuals with high-impact chronic pain, enhancing access to evidence-based care.

Clinical Updates Wellness & Lifestyle

Structured vs Self-Guided Multidomain Lifestyle Interventions for Cognitive Health: Insights from the US POINTER Randomized Clinical Trial

By MedXY 07/30/2025

A large US trial found that structured, intensive lifestyle interventions led to greater improvements in global cognition over two years compared to self-guided approaches among older adults at risk for cognitive decline.

Clinical Updates Wellness & Lifestyle

Demographic Data Gaps in FDA Authorization of AI-Based Devices for Alzheimer’s Disease and Related Dementias

By MedXY 07/30/2025

Limited demographic data transparency in FDA-authorized AI devices for Alzheimer’s may hinder equitable care and generalizability, highlighting a crucial need for improved dataset representativeness and regulatory oversight.

Clinical Updates Medical News

Influenza-Associated Acute Necrotizing Encephalopathy in US Children

By MedXY 07/30/2025

A multicenter US study highlights the devastating burden of influenza-associated acute necrotizing encephalopathy in children, with high mortality and disability rates despite aggressive therapy, underscoring the urgent need for prevention and standardized management.

Medical News Wellness & Lifestyle

Systemic Bias in AI: A Double-Edged Sword for Hospital Diagnostic Accuracy

By MedXY 07/30/2025

Systemically biased AI models can reduce clinicians' diagnostic accuracy, and explanations alone may not mitigate this harm, according to a multicenter study involving over 450 clinicians.

Clinical Updates Wellness & Lifestyle

Low Lupus Activity as a Predictive Target in Lupus Nephritis: A Clinical Appraisal of LLDAS

By MedXY 07/30/2025

Achieving low lupus disease activity (LLDAS) at 12 months is an attainable target in lupus nephritis and independently predicts reduced relapse risk and preserved renal function, supporting its potential as a future treatment goal.

Medical News

Johns Hopkins Hospital Leads U.S. News Rheumatology Rankings

By Dr.Paul 07/30/2025

Highlight Johns Hopkins Hospital is ranked as the best hospital for rheumatology for the 8th…

Understanding Adult Responses to Cannabis Health Warnings in US Recreational States: Insights from the EPPM Model

Long-Term Fracture Risk After Menopausal Hormone Therapy: New Insights from a Landmark Study

JAK Inhibitors and Venous Thromboembolism in Atopic Dermatitis: Clinical Risks and Practice Implications

High Tibial Osteotomy May Slow Knee Osteoarthritis Progression in Bowlegged Patients: Clinical Insights from a Randomized Trial

FDA Approves Sephience: A New Oral Therapy for Phenylketonuria

EMA Recommends First Oral On-Demand Therapy for Hereditary Angioedema: A Paradigm Shift in Acute Attack Management

EMA Recommends Voranigo for IDH-Mutant Grade 2 Glioma: A New Era in Targeted Brain Tumor Therapy

Parathyroidectomy Enhances Muscle Health in Postmenopausal Women with Primary Hyperparathyroidism

Unraveling the Drivers of Pruritus Severity in Intrahepatic Cholestasis of Pregnancy: Insights from a Longitudinal Cohort Study

Early Postoperative PTH as a Reliable Predictor of Hypoparathyroidism After Total Thyroidectomy

Legacy of Leaded Gasoline: New Evidence Links Childhood and Adult Exposure to Cognitive Impairment in Older Adults

CDC Retracts Universal COVID-19 Vaccination Recommendation for Pregnancy: Clinical Context, Evidence, and Implications

Is There a Norovirus Vaccine on the Horizon? Scientific Progress, Challenges, and Future Directions

Expanding Access to Chronic Pain Care: Telehealth and Online CBT-Based Interventions Show Promise

Structured vs Self-Guided Multidomain Lifestyle Interventions for Cognitive Health: Insights from the US POINTER Randomized Clinical Trial

Demographic Data Gaps in FDA Authorization of AI-Based Devices for Alzheimer’s Disease and Related Dementias

Influenza-Associated Acute Necrotizing Encephalopathy in US Children

Systemic Bias in AI: A Double-Edged Sword for Hospital Diagnostic Accuracy

Low Lupus Activity as a Predictive Target in Lupus Nephritis: A Clinical Appraisal of LLDAS

Johns Hopkins Hospital Leads U.S. News Rheumatology Rankings

Immunogenicity and Safety of the VLA15 Lyme Borreliosis Vaccine Across Age Groups: A Phase 2 Randomised Controlled Trial and Integrative Review

MACRO Trial Insights: Endoscopic Sinus Surgery Outperforms Clarithromycin in Chronic Rhinosinusitis Management

Adjunctive Corticosteroids in Severe Pneumocystis jirovecii Pneumonia Among HIV-negative Patients: Insights from a Multicentre Randomised Trial

Evaluating BDLC Regimen in Pre-XDR Tuberculosis: Findings from the endTB-Q Phase 3 Trial