Medxy AI

Dual IL-17A/F Blockade and Increased Candidiasis Risk

By MedXY 07/31/2025

Blocking both IL-17A and IL-17F impairs neutrophil migration, reducing antifungal defense and raising candidiasis risk in patients on bimekizumab, according to in vitro evidence.

Clinical Updates Wellness & Lifestyle

Inconsistent Bone Health Management in Older Women With Breast Cancer: Insights From the Age Gap Study

By MedXY 07/31/2025

Significant variation exists in bone health management for older women receiving endocrine therapy for breast cancer, highlighting the need for standardized care.

Clinical Updates

多発性筋痛症が死亡リスクの増加と関連しないこと：38年間のノルウェー集団研究からの洞察

By MedXY 07/31/2025

ノルウェー南部での38年間の前向き研究は、単独の多発性筋痛症（PMR）が対照群と比較して全原因による死亡リスクを増加させないことを示しています。男性ではさらに低い死亡リスクが見られました。

Clinical Updates Wellness & Lifestyle

Polymyalgia Rheumatica Not Associated with Increased Mortality: Insights from a 38-Year Norwegian Cohort Study

By MedXY 07/31/2025

A 38-year prospective study in Southern Norway demonstrates that isolated polymyalgia rheumatica (PMR) does not increase all-cause mortality compared to matched population controls, with men showing even lower mortality risk.

Clinical Updates Wellness & Lifestyle

ED Intubation in Active Hemorrhage Linked to Increased Mortality: Insights from a Nationwide Cohort Study

By MedXY 07/31/2025

Intubation in the emergency department for trauma patients with active hemorrhage is associated with higher mortality, more ICU admissions, and greater transfusion needs compared to intubation in the operating room.

Clinical Updates Wellness & Lifestyle

Veligrotug Emerges as a Promising Therapy for Thyroid Eye Disease: Insights from the THRIVE and THRIVE-2 Trials

By MedXY 07/31/2025

Veligrotug demonstrates robust efficacy and manageable safety in both active and chronic thyroid eye disease, positioning itself as a potential alternative to teprotumumab based on phase 3 THRIVE trial data.

Clinical Updates Wellness & Lifestyle

Inhaled Isoflurane: A Noninferior Alternative to Midazolam for Pediatric ICU Sedation

By MedXY 07/31/2025

A multicenter phase 3 trial finds inhaled isoflurane as effective as intravenous midazolam for sedation in mechanically ventilated children, with added benefits of reduced opioid use and faster extubation.

Wellness & Lifestyle

Sweetener Consumption and Genetic Predisposition: New Insights into Early Puberty Risk in Children

By Dr.Paul 07/31/2025

Sweetener intake, especially aspartame and sucralose, is linked to increased risk of early puberty in genetically predisposed children, with notable sex-specific differences

Medical News Wellness & Lifestyle

Benzene in Acne Products: Clinical Implications, Risks, and Regulatory Response

By MedXY 07/31/2025

Recent findings of benzene in benzoyl peroxide acne products have sparked debate, recalls, and regulatory scrutiny, prompting calls for improved safety measures despite the continued clinical utility of these therapies.

Clinical Updates Wellness & Lifestyle

Ovarian Cancer Risk Peaks Shortly After New IBS Diagnosis: Clinical Implications and Evidence Review

By MedXY 07/31/2025

A new IBS diagnosis is associated with a transiently increased risk of ovarian cancer, especially within the first 6 months, emphasizing the need for heightened clinical vigilance.

Clinical Updates Wellness & Lifestyle

Rapid Initial Benefits of Secukinumab in Early Psoriatic Arthritis: Insights from a Treat-to-Target Randomized Trial

By MedXY 07/31/2025

Early secukinumab use in newly diagnosed psoriatic arthritis delivers faster clinical improvement at 3 months compared to standard care, but this advantage diminishes by 6 months and beyond.

Clinical Updates Medical News

Aluminum-Adjuvanted Vaccines in Early Childhood and Risk of Chronic Autoimmune, Allergic, and Neurodevelopmental Disorders: Insights from a Danish Nationwide Cohort Study

By MedXY 07/31/2025

A comprehensive Danish cohort study finds no evidence linking early childhood aluminum-adsorbed vaccines to increased risks of autoimmune, allergic, or neurodevelopmental disorders, supporting vaccine safety.

Clinical Updates Wellness & Lifestyle

GLP-1 Receptor Agonists and Risk of GERD in Type 2 Diabetes: Clinical Implications from a Large Population-Based Cohort Study

By MedXY 07/31/2025

GLP-1 receptor agonists modestly increase the risk of GERD and its complications compared to SGLT-2 inhibitors in type 2 diabetes patients, highlighting the need for vigilant symptom monitoring.

Clinical Updates Wellness & Lifestyle

Weekend Warrior Exercise Patterns: Comparable Cardiometabolic Protection to Regular Activity in Diabetes and MASLD

By MedXY 07/31/2025

Accumulating 150 minutes of moderate-to-vigorous physical activity weekly, either as a 'weekend warrior' or in regular sessions, significantly reduces mortality and cardiometabolic risk in adults with diabetes and MASLD.

Clinical Updates Wellness & Lifestyle

GLP-1 Receptor Agonists and Dementia Risk in Older Adults With Type 2 Diabetes: Insights From a Target Trial Emulation

By MedXY 07/31/2025

A large-scale emulated trial found no clear overall reduction in dementia risk with GLP-1 receptor agonists versus DPP-4 inhibitors in older adults with type 2 diabetes, though age-specific effects warrant further investigation.

Clinical Updates Medical News

Medial Opening Wedge High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis: Evidence from a Randomized Controlled Trial

By MedXY 07/31/2025

A randomized trial demonstrates that medial opening wedge high tibial osteotomy (HTO) slows cartilage loss and improves symptoms in patients with medial compartment knee osteoarthritis and varus alignment, supporting its role as a joint-preserving intervention.

Clinical Updates Wellness & Lifestyle

Rituximab Shows No Superiority Over Conventional Therapy for EGPA Remission Induction

By MedXY 07/31/2025

A phase 3 randomized trial found rituximab no more effective than standard glucocorticoid-based therapy in inducing remission in eosinophilic granulomatosis with polyangiitis (EGPA), with comparable safety and relapse profiles.

Medical News Wellness & Lifestyle

Obesity-Linked Liver Cancer: A Preventable Crisis on the Rise

By MedXY 07/31/2025

Over 60% of liver cancer cases are preventable, yet rising obesity and metabolic dysfunction threaten progress. The Lancet Commission outlines urgent strategies to curb a projected doubling of global liver cancer burden by 2050.

Medical News Wellness & Lifestyle

Preterm Birth Linked to Long-Term Adult Cardiometabolic and Mental Health Risks: New U.S. Cohort Study

By MedXY 07/30/2025

Adults born preterm face significantly higher risks of cardiometabolic abnormalities and internalizing mental health problems by age 35, according to a new U.S. cohort study.

Dual IL-17A/F Blockade and Increased Candidiasis Risk

Inconsistent Bone Health Management in Older Women With Breast Cancer: Insights From the Age Gap Study

多発性筋痛症が死亡リスクの増加と関連しないこと：38年間のノルウェー集団研究からの洞察

Polymyalgia Rheumatica Not Associated with Increased Mortality: Insights from a 38-Year Norwegian Cohort Study

ED Intubation in Active Hemorrhage Linked to Increased Mortality: Insights from a Nationwide Cohort Study

Veligrotug Emerges as a Promising Therapy for Thyroid Eye Disease: Insights from the THRIVE and THRIVE-2 Trials

Inhaled Isoflurane: A Noninferior Alternative to Midazolam for Pediatric ICU Sedation

Sweetener Consumption and Genetic Predisposition: New Insights into Early Puberty Risk in Children

Benzene in Acne Products: Clinical Implications, Risks, and Regulatory Response

Ovarian Cancer Risk Peaks Shortly After New IBS Diagnosis: Clinical Implications and Evidence Review

Rapid Initial Benefits of Secukinumab in Early Psoriatic Arthritis: Insights from a Treat-to-Target Randomized Trial

Aluminum-Adjuvanted Vaccines in Early Childhood and Risk of Chronic Autoimmune, Allergic, and Neurodevelopmental Disorders: Insights from a Danish Nationwide Cohort Study

GLP-1 Receptor Agonists and Risk of GERD in Type 2 Diabetes: Clinical Implications from a Large Population-Based Cohort Study

Weekend Warrior Exercise Patterns: Comparable Cardiometabolic Protection to Regular Activity in Diabetes and MASLD

GLP-1 Receptor Agonists and Dementia Risk in Older Adults With Type 2 Diabetes: Insights From a Target Trial Emulation

Medial Opening Wedge High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis: Evidence from a Randomized Controlled Trial

Rituximab Shows No Superiority Over Conventional Therapy for EGPA Remission Induction

Obesity-Linked Liver Cancer: A Preventable Crisis on the Rise

Preterm Birth Linked to Long-Term Adult Cardiometabolic and Mental Health Risks: New U.S. Cohort Study

Immunogenicity and Safety of the VLA15 Lyme Borreliosis Vaccine Across Age Groups: A Phase 2 Randomised Controlled Trial and Integrative Review

MACRO Trial Insights: Endoscopic Sinus Surgery Outperforms Clarithromycin in Chronic Rhinosinusitis Management

Adjunctive Corticosteroids in Severe Pneumocystis jirovecii Pneumonia Among HIV-negative Patients: Insights from a Multicentre Randomised Trial

Evaluating BDLC Regimen in Pre-XDR Tuberculosis: Findings from the endTB-Q Phase 3 Trial