Posted innews
门诊与住院治疗低风险PSBI婴儿：来自撒哈拉以南非洲和南亚多中心试验的见解
一项随机试验发现，对具有单一低死亡风险PSBI症状的婴儿进行门诊治疗不劣于住院治疗，且死亡率更低，安全性相当。
Posted inInfectious Diseases news Pediatrics
Optimizing Antibiotic Duration in Young Infants with Possible Serious Bacterial Infection: A Landmark Multicountry RCT
This multicountry trial demonstrates that early switch from injectable to oral antibiotics with early discharge in young infants with moderate-risk serious bacterial infections is safe and effective, with potential to optimize healthcare resources and reduce hospital stays.
Posted inHIV/AIDS Infectious Diseases Specialties
Understanding Motivations and Barriers in Donation-Based HIV/STI Interventions: Insights from a Systematic Review
This review synthesizes motivations, facilitators, and barriers of donation-based interventions in HIV/STI research, revealing key factors that enhance access to services through prosocial behaviors in diverse global settings.
Xenotransplantation: Bridging the Gap in Liver Transplantation with Genetically Modified Pig Organs
Recent advances in genetically modified pig-to-human organ transplantation offer promising solutions for acute liver failure, bridging critical gaps in organ availability and raising important ethical and regulatory considerations.
Evaluating Fentanyl Use in Pediatric Ileocolic Intussusception Reduction: Implications for Pain Management and Success Rates
A large multicenter study finds no association between fentanyl administration and failed reduction of pediatric ileocolic intussusception, supporting its safe use for analgesia during the painful reduction procedure.
Persistent Olfactory Dysfunction Following SARS-CoV-2 Infection: Insights from the RECOVER Adult Cohort
A large prospective study demonstrates that olfactory dysfunction is prevalent and often clinically unrecognized long after SARS-CoV-2 infection, highlighting the value of formal smell testing in patient care and cognitive risk assessment.
Severe Symptomatic Arterial Vasospasm Following Pituitary Surgery: A Rare Case and Systematic Review of the Literature
We report a rare case of severe symptomatic arterial vasospasm after pituitary surgery, accompanied by a systematic review highlighting risk factors, clinical presentation, treatment strategies, and outcomes for this life-threatening complication.
Posted inPsychiatry Public Health Specialties
Decoding Conspiratorial Thinking Across America: Insights from a Nationwide Survey
A comprehensive 50-state survey reveals widespread conspiratorial thinking among American adults linked to demographic factors and COVID-19 vaccine hesitancy, with implications for public health strategies.
Evaluating Telestroke’s Impact on Acute Ischemic Stroke Treatment Timeliness and Outcomes
Telestroke evaluation increases thrombolysis rates but is associated with longer treatment times and delays in patient transfers in acute ischemic stroke, highlighting the need to address modifiable treatment delays.
Semaglutide for Metabolic Health in Schizophrenia: Insights from the HISTORI RCT
The HISTORI trial demonstrates that semaglutide significantly improves glycemic control, reduces weight, and enhances physical quality of life in schizophrenia patients treated with second-generation antipsychotics, without worsening psychiatric symptoms.
Posted inOncology Otorhinolaryngology Radiology Specialties
Evaluating Radiologic Extranodal Extension in HPV-Positive Oropharyngeal Cancer: Accuracy, Prognostic Value, and Clinical Implications from a Multinational Real-World Study
This multinational real-world study reveals limited sensitivity and prognostic value of radiologic extranodal extension (iENE) in HPV-positive oropharyngeal cancer, highlighting the enhanced accuracy with combined CT and MRI and the need for standardized diagnostic criteria.
Posted innews Oncology Otorhinolaryngology
Imaging-Detected Extranodal Extension as a Predictor of Distant Recurrence in HPV-Positive Oropharyngeal Cancer
Imaging-based extranodal extension (iENE) in HPV-positive oropharyngeal cancer predicts higher rates of distant metastases and decreased progression-free survival, highlighting its prognostic significance and potential role in refining staging and treatment planning.
Posted inOncology Otorhinolaryngology Specialties
Revising the TNM Classification for HPV-Associated Oropharyngeal Carcinoma: Improving Prognostic Stratification with Imaging-Detected Extranodal Extension
A new clinical TNM staging proposal incorporating imaging-detected extranodal extension (iENE) refines prognostic accuracy in HPV-positive oropharyngeal carcinoma, aiding risk stratification and future treatment strategies.
Posted inAI Oncology Otorhinolaryngology Radiology Specialties
Artificial Intelligence in Imaging-Based Extranodal Extension Detection: Advancing Prognostication in HPV-Positive Oropharyngeal Cancer
An AI-driven model accurately detects imaging-based extranodal extension in HPV-positive oropharyngeal cancer from CT scans, improving outcome prediction beyond expert radiologist assessments and identifying patients at higher risk of poorer survival and recurrence.
Posted inNeurology Specialties
Early Intravenous Immunoglobulin Therapy Improves Long-Term Outcomes in Anti-IgLON5 Disease
This retrospective multicenter study found that early intravenous immunoglobulin treatment in anti-IgLON5 disease is linked to reduced disability and mortality, highlighting a promising immunotherapeutic strategy for this rare autoimmune encephalopathy.
Basophil Activation Test: A Superior Predictor for Allergic Reactions to Baked and Fresh Cow’s Milk in Children
The Basophil Activation Test offers the highest accuracy in predicting allergic reactions to baked and fresh cow's milk during oral food challenges, reducing the need for riskier diagnostic tests in children with milk allergy.
Posted inOphthalmology Specialties
Metformin and Age-Related Macular Degeneration: Current Evidence on Development and Progression
This review synthesizes current evidence from large cohorts, meta-analyses, and randomized trials evaluating metformin's association with AMD development and progression, highlighting a nuanced but inconclusive protective potential requiring further prospective studies.
Posted inCritical Care General Surgery Specialties
Enhancing Surgical Patient Safety: Impact of the SIPS Handover System on Clinical Outcomes
The SIPS surgical handover system significantly improves handover quality, patient vital signs, and staff safety perceptions without prolonging meeting times, enhancing safety in emergency general surgery.
Impact of Early Extracranial Surgery on One-Year Outcomes After Traumatic Brain Injury: Insights from the TRACK-TBI Study
Early extracranial surgery following moderate-severe traumatic brain injury or positive CT findings is linked to worse cognitive, functional, and quality of life outcomes at one year, highlighting the need to refine surgical timing and post-injury interventions.
Posted inNeurology news Rehabilitation Medicine Specialties
Evaluating Electromagnetic Network-Targeted Field Therapy for Post-Ischemic Stroke Disability: Insights from the EMAGINE Trial
The EMAGINE randomized clinical trial assessed low-intensity electromagnetic stimulation combined with rehabilitation in moderate to severe ischemic stroke patients. While safe, it did not yield statistically significant functional improvement, warranting further investigation.
