Blackcurrant Anthocyanins Improve Post‑prandial Vascular Function and Platelet Reactivity — Acute RCT Insights and Clinical Implications
Posted inClinical Updates Wellness & Lifestyle

Blackcurrant Anthocyanins Improve Post‑prandial Vascular Function and Platelet Reactivity — Acute RCT Insights and Clinical Implications

A randomized, double‑blind crossover trial found that a single 200‑mL anthocyanin‑rich blackcurrant beverage (711 mg anthocyanins) attenuated the adverse postprandial effects of a high‑fat meal on flow‑mediated dilation, platelet aggregation, and IL‑8 in healthy adults; effects were linked to specific phenolic metabolites.
Blackcurrant Anthocyanins Improve Postprandial Vascular Function and Platelet Reactivity: Acute Crossover Trial Highlights Metabolites Linked to Benefit
Posted inClinical Updates Wellness & Lifestyle

Blackcurrant Anthocyanins Improve Postprandial Vascular Function and Platelet Reactivity: Acute Crossover Trial Highlights Metabolites Linked to Benefit

In a randomized, double‑blind crossover trial, a 200 mL anthocyanin‑rich blackcurrant beverage (≈711 mg anthocyanins) taken with a high‑fat meal improved flow‑mediated dilation and reduced agonist‑induced platelet aggregation and IL‑8 over 6 hours in healthy middle‑aged adults; specific circulating phenolic metabolites correlated with the responses.
Urolithin A for Muscle Health: A 4‑Month Randomized Trial Shows Improved Lower‑Limb Strength, Endurance Signals, and Mitochondrial Biomarkers
Posted inClinical Updates Wellness & Lifestyle

Urolithin A for Muscle Health: A 4‑Month Randomized Trial Shows Improved Lower‑Limb Strength, Endurance Signals, and Mitochondrial Biomarkers

In a randomized, double‑blind 4‑month trial of middle‑aged overweight adults, oral urolithin A improved hamstring strength (~10–12%), increased peak VO2 and 6‑minute walk distance (clinically meaningful at 33 m for 1,000 mg), altered mitochondrial proteomic signatures, and reduced inflammation without major safety signals.
Medium‑Chain Triglyceride–Supplemented Ketogenic Diet in Parkinson’s Disease: A Small Randomized Feasibility Trial and What It Means for Clinical Practice
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Medium‑Chain Triglyceride–Supplemented Ketogenic Diet in Parkinson’s Disease: A Small Randomized Feasibility Trial and What It Means for Clinical Practice

A randomized, double‑blind pilot tested an MCT‑supplemented ketogenic diet (MCT‑KD) in 16 people with moderate Parkinson’s disease. The diet was feasible and acceptable, induced nutritional ketosis by day 4, produced metabolic benefits and nonmotor symptom improvement, but did not change a primary mobility endpoint (TUG) over three weeks.
Posted inClinical Updates Wellness & Lifestyle

Ketogenic Diet vs Further Antiseizure Medication in Infants with Drug-Resistant Epilepsy: What the KIWE Trial Adds to Clinical Practice

The KIWE randomised trial (Lancet Neurol 2023) found no superiority of a classic ketogenic diet over an additional antiseizure medication for seizure frequency in infants (1–24 months) with drug‑resistant epilepsy; tolerability and safety profiles were similar, supporting the diet as a viable treatment option.