Early Neuromuscular Electrical Stimulation Plus Mobilization Improves 6‑Month Function and Quality of Life After Critical Illness
Posted inCritical Care news Rehabilitation Medicine

Early Neuromuscular Electrical Stimulation Plus Mobilization Improves 6‑Month Function and Quality of Life After Critical Illness

In a randomized, blinded trial of 74 mechanically ventilated ICU patients, adding early NMES to an early mobilization program started within 48 hours improved functional status, independence, mobility, and quality of life up to 6 months after discharge versus mobilization alone.
ICU Structure and Care Processes Drive VAP and CLABSI Burden in Brazilian ICUs: Insights from the IMPACTO‑MR Nested Cohort
Posted inCritical Care Infectious Diseases news

ICU Structure and Care Processes Drive VAP and CLABSI Burden in Brazilian ICUs: Insights from the IMPACTO‑MR Nested Cohort

A large multicenter Brazilian cohort found that ICU-level structure and process measures — staffing, prevention protocols, hand hygiene training, visitation policies, and specific clinical roles — explain substantial between-hospital variability and are associated with lower VAP and CLABSI rates.
Neoadjuvant Checkpoint Inhibitors with Chemotherapy Improve Outcomes in Early Triple‑Negative and PD‑L1+ HR‑Positive Breast Cancer — A Critical Appraisal of Recent Meta‑Analysis
Posted innews Oncology

Neoadjuvant Checkpoint Inhibitors with Chemotherapy Improve Outcomes in Early Triple‑Negative and PD‑L1+ HR‑Positive Breast Cancer — A Critical Appraisal of Recent Meta‑Analysis

A patient‑level and trial‑level meta‑analysis of nine RCTs (5,114 patients) shows that adding immune checkpoint inhibitors to neoadjuvant chemotherapy improves pathologic complete response and event‑free survival in triple‑negative breast cancer and PD‑L1+ HR+/ERBB2‑ tumors, with a manageable immune toxicity profile.
Prothrombin Complex Concentrate versus Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery: Evidence Synthesis from the FARES-II Multicenter Randomized Clinical Trial and Related Studies
Posted inCardiology Clinical Updates General Surgery news

Prothrombin Complex Concentrate versus Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery: Evidence Synthesis from the FARES-II Multicenter Randomized Clinical Trial and Related Studies

This review synthesizes evidence demonstrating that 4-factor prothrombin complex concentrate (4F-PCC) offers superior hemostatic efficacy and safety compared to frozen plasma in managing coagulopathic bleeding during cardiac surgery, supported by the recent FARES-II trial and corroborating clinical research.
Cryopreserved Versus Liquid-Stored Platelets in Surgical Bleeding: Insights from the CLIP-II Randomized Noninferiority Trial
Posted inClinical Updates General Surgery news

Cryopreserved Versus Liquid-Stored Platelets in Surgical Bleeding: Insights from the CLIP-II Randomized Noninferiority Trial

The CLIP-II trial evaluated dimethyl sulfoxide-cryopreserved platelets with extended shelf-life against conventional liquid-stored platelets in cardiac surgery bleeding, finding noninferiority was not established and cryopreserved platelets showed reduced hemostatic effectiveness despite similar safety profiles.
Effectiveness of Automated Closed-Loop Ventilation versus Protocolized Conventional Ventilation in Critically Ill Adults: A Comprehensive Evidence Review
Posted inClinical Updates Critical Care news Respiratory

Effectiveness of Automated Closed-Loop Ventilation versus Protocolized Conventional Ventilation in Critically Ill Adults: A Comprehensive Evidence Review

Automated closed-loop ventilation improves ventilation quality but does not increase ventilator-free days at day 28 compared to protocolized conventional ventilation in critically ill adults, with benefits in safety profiles and caregiver workload.