ほとんどの極低出生体重児は2歳前に再入院を必要とする — 新生児期の病態が病院滞在日数を大幅に増加させる
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ほとんどの極低出生体重児は2歳前に再入院を必要とする — 新生児期の病態が病院滞在日数を大幅に増加させる

イングランドとウェールズの全国コホート研究によると、32週未満で生まれた乳児のうち、2歳までに1回以上の入院を経験した割合が2/3に達し、周産期の低出生体重と新生児期の病態（BPD、重度NEC、脳損傷）が総入院日数を大幅に増加させている。
Breast Cancer Index in Premenopausal HR+ Disease: Prognostic Confirmed, Predictive Role for OFS-Intensification Context-Dependent
Posted innews Oncology

Breast Cancer Index in Premenopausal HR+ Disease: Prognostic Confirmed, Predictive Role for OFS-Intensification Context-Dependent

Two large prospective‑retrospective analyses confirm BCI as a robust prognostic biomarker in premenopausal HR+ breast cancer; its HOXB13/IL17BR (H/I) component predicted benefit from adding ovarian function suppression versus tamoxifen alone but did not clearly predict superiority of exemestane+OFS over tamoxifen+OFS.
Early‑Onset Colorectal Cancer: Parsing an Epidemiologic Artifact from True Molecular Signals — Toward a Clinically Actionable Molecular Taxonomy
Posted inGastroenterology news Oncology Pathology & Lab Medicine

Early‑Onset Colorectal Cancer: Parsing an Epidemiologic Artifact from True Molecular Signals — Toward a Clinically Actionable Molecular Taxonomy

Integrated analysis shows a 2013 NEN classification change inflated EOCRC counts in the youngest adults, while independent molecular studies reveal distinct hypermutated and non‑hypermutated EOCRC subtypes with higher MSI/TMB and pathway-specific differences across populations. Implications for diagnosis, surveillance, and precision therapy are discussed.
Planetary Health Diet and Cardiometabolic Risk Reduction in Women with Gestational Diabetes: An Evidence-Based Review
Posted inClinical Updates Diabetes & Endocrinology Family Medicine & Nutrition news OB/GYN & Women's Health

Planetary Health Diet and Cardiometabolic Risk Reduction in Women with Gestational Diabetes: An Evidence-Based Review

This review synthesizes evidence linking adherence to the Planetary Health Diet with reduced risks of myocardial infarction, type 2 diabetes, and improved weight management in women post-gestational diabetes, highlighting BMI's mediating role.
Epinephrine Timing and Dosing in Pediatric In‑Hospital Cardiac Arrest: Mixed Signals — improved ROSC but unclear survival benefit
Posted inCritical Care news Pediatrics

Epinephrine Timing and Dosing in Pediatric In‑Hospital Cardiac Arrest: Mixed Signals — improved ROSC but unclear survival benefit

Recent multicenter studies show earlier and more frequent epinephrine in pediatric in‑hospital cardiac arrest increases ROSC and shortens CPR, but does not consistently improve survival to discharge or favorable neurologic outcome. Evidence supports rapid epinephrine for hemodynamics and ROSC; survival effects remain uncertain.
Offering Multiple Appropriate Alternatives Increases Primary Care Physicians’ Adoption of Recommended Care: A Randomized Trial
Posted inFamily Medicine & Nutrition news Nursing & care

Offering Multiple Appropriate Alternatives Increases Primary Care Physicians’ Adoption of Recommended Care: A Randomized Trial

A randomized trial of 402 US primary care physicians found that presenting two or more appropriate treatment alternatives (vs one) increased clinicians’ likelihood of changing from a status quo plan to an evidence‑based alternative, especially for opioid prescribing; adding options beyond two provided no further benefit.
Pediatric In‑Hospital Cardiac Arrest: Why Adult Resuscitation Lessons Don’t Fully Translate — Airway, Epinephrine, and the Limits of Training
Posted inCritical Care news Pediatrics

Pediatric In‑Hospital Cardiac Arrest: Why Adult Resuscitation Lessons Don’t Fully Translate — Airway, Epinephrine, and the Limits of Training

Recent multicenter studies show declining intra‑arrest intubation, no clear harm from intubation after time‑dependent matching, unclear benefit of epinephrine before defibrillation, and no survival gain from intensive point‑of‑care CPR training—highlighting pediatric physiology and knowledge gaps.
Prehospital Postintubation Hypotension Strongly Linked to 30‑Day Mortality After Severe Traumatic Brain Injury — Especially in Isolated TBI
Posted inCritical Care Emergency Medicine Neurology news

Prehospital Postintubation Hypotension Strongly Linked to 30‑Day Mortality After Severe Traumatic Brain Injury — Especially in Isolated TBI

A multicenter cohort study of 555 patients with severe TBI who underwent prehospital rapid sequence induction found postintubation hypotension (SBP <90 mmHg within 10 minutes) in 19.1%, which was associated with higher 30‑day mortality (AOR 1.70). The association was markedly stronger in isolated TBI (AOR 13.55).
Early-Life Famine Exposure in Chinese Immigrants Strongly Linked to Later Diabetes and Hypertension — But Not Cardiovascular Hospitalization
Posted inDiabetes & Endocrinology news Public Health

Early-Life Famine Exposure in Chinese Immigrants Strongly Linked to Later Diabetes and Hypertension — But Not Cardiovascular Hospitalization

A large Ontario cohort study links early-life exposure to the Great Chinese Famine with higher adult risks of type 2 diabetes and hypertension among Chinese immigrants, while cardiovascular hospitalization was not increased; methodological caveats underline need for age-balanced research.
Tailored Digital Emotion Regulation Improves Mental Health in Adults With Congenital Heart Disease: Results of a National Randomized Trial
Posted inCardiology news Psychiatry

Tailored Digital Emotion Regulation Improves Mental Health in Adults With Congenital Heart Disease: Results of a National Randomized Trial

A 3‑arm randomized trial in 524 adults with congenital heart disease found a 4‑week tailored digital emotion‑regulation program produced moderate improvements in emotion regulation and multiple psychosocial outcomes versus usual care; a general program showed delayed, smaller benefits.