Five-Year Safety of Avoiding Biopsy After Negative MRI in Prostate Cancer Pathways
Long-term data show RAPID MRI-directed pathway safely avoids unnecessary biopsies while maintaining low rates of clinically significant prostate cancer.
Refining Prostate Cancer Risk Prediction in Men of African Ancestry: Integrating Pathogenic Variants, Polygenic Scores, and Family History
This study identifies key germline variants and demonstrates how combining genetic data with family history improves personalized prostate cancer risk assessment in men of African ancestry, guiding future screening strategies.
Personalizing Breast Cancer Screening: Insights from the WISDOM Trial on Risk-Based vs Annual Mammography
The WISDOM trial shows risk-based breast cancer screening using genetic and clinical data as a safe alternative to annual mammography, tailoring screening frequency by individual risk without increasing advanced cancer rates.
Posted inCardiology Infectious Diseases news
Prophylactic Strategies to Prevent Infection in Lower Limb Peripheral Arterial Reconstruction: Evidence and Clinical Implications
Cochrane review shows prophylactic antibiotics may reduce SSI risk in peripheral arterial reconstruction; closed incision negative pressure therapy offers possible benefit but evidence is low.
Chemoendocrine Therapy Linked to Greater Cognitive Decline in Breast Cancer Patients, Regardless of Menopausal Status
A secondary analysis of the RxPONDER trial finds chemoendocrine therapy causes more lasting cognitive impairment than endocrine therapy alone in both pre- and postmenopausal women.
Posted innews Otorhinolaryngology Respiratory
Biofeedback vs Respiratory Retraining: No Significant Difference in Inducible Laryngeal Obstruction Relief
A pilot trial finds biofeedback and respiratory retraining equally effective for inducible laryngeal obstruction, offering clinicians flexible, patient-tailored options.
Posted inNeurology news Psychiatry
Elevated Serotonin Release in Schizophrenia: New Insights Into Negative Symptom Pathophysiology
A PET imaging study reveals increased frontal serotonin release in schizophrenia, particularly in deficit type, tied to worse negative symptoms.
Posted inCardiology Neurology news
Combined Cardiorespiratory and Resistance Training After Stroke: Small Gains, Big Questions
Evidence suggests combined aerobic and strength training post-stroke yields modest improvements in fitness and function but uncertain long-term benefits.
Do Behavioural, Self-Management, and Service Delivery Models Improve Outcomes in Adults with Epilepsy?
A Cochrane review finds limited and low- to moderate-certainty evidence that behavioural, self-management, or service delivery interventions improve seizure control or quality of life in adults with epilepsy.
Posted inDiabetes & Endocrinology Neurology news
Omega-3 Fatty Acids Show Limited Benefits for Diabetic Peripheral Neuropathy
Current evidence suggests minimal impact of omega-3 supplementation on neuropathy symptoms or quality of life in adults with diabetes.
Posted innews
Progestagens Show Promise for Pain Relief in Endometriosis, With Nuanced Efficacy Across Comparators
Oral progestagens likely reduce overall pain and dysmenorrhoea in endometriosis, but comparative benefits over other hormonal treatments remain uncertain.
Posted inCardiology news
Rare but High-Risk: New-Onset RBBB After TAVR Strongly Linked to Pacemaker Need
New-onset right bundle branch block after TAVR is rare but carries a high risk of requiring permanent pacing within one week.
Posted inCardiology news
Prophylactic Pacemakers After TAVR: Low Pacing Burden Raises Questions on Routine Use
One-fourth of TAVR patients receive prophylactic pacemakers, but most have minimal pacing needs at 30 days.
Posted inCardiology news
PROMOTE Study Validates Algorithm for Conduction Disturbance Management After TAVR
A prospective multicenter study confirms that a prespecified algorithm for conduction disturbance management after TAVR is safe, with low sudden cardiac death risk but persistent high pacemaker rates.
Posted inCardiology news
Distinct Mechanisms Drive Early and Delayed Heart Block After TAVR: Insights from Boston Cohort Study
Prospective cohort study reveals AV nodal versus infranodal conduction patterns underpinning timing of heart block after TAVR.
Posted innews Orthopedics
Cryotherapy After Total Knee Replacement: Limited Evidence for Modest Benefits
Low-certainty evidence suggests cryotherapy may slightly reduce blood loss, pain, and swelling after total knee replacement, but clinical relevance remains uncertain.
Posted inCritical Care news Pediatrics
Rethinking Oxygen Strategies for Preterm Infant Resuscitation: Evidence from TORPIDO, IPD-MA, and DCC Trials
Recent trials and meta-analyses challenge assumptions about optimal initial oxygen levels for preterm resuscitation.
Broad Genetic Testing Reveals Hidden Breast Cancer Risk in Women Without Family History
The WISDOM trial found that 3.1% of women without breast cancer carried pathogenic variants in key susceptibility genes, many outside existing testing guidelines.
Posted innews OB/GYN & Women's Health
Progestagens Show Moderate Efficacy for Endometriosis Pain, But Evidence Variability Limits Clinical Certainty
Oral progestagens reduce overall pain and dysmenorrhoea in endometriosis, but comparative benefits over other hormonal therapies remain uncertain.
Posted innews OB/GYN & Women's Health Oncology
Simple vs Radical Hysterectomy: Balancing Survival Outcomes and Quality of Life in Early Cervical Cancer
Evidence suggests simple hysterectomy with pelvic lymphadenectomy may offer similar survival outcomes to radical hysterectomy in early-stage cervical cancer, with fewer adverse events and better short-term quality of life.
