Selective JAK2 Inhibition OB756 Shows Promise in Hydroxyurea/Interferon‑Intolerant or -Resistant Essential Thrombocythemia
Posted inHematology-Oncology news

Selective JAK2 Inhibition OB756 Shows Promise in Hydroxyurea/Interferon‑Intolerant or -Resistant Essential Thrombocythemia

A Phase II multicenter study reports that OB756, a selective JAK2 inhibitor, is active and reasonably well tolerated in hydroxyurea- or interferon-intolerant/resistant essential thrombocythemia, producing platelet and leukocyte control, spleen volume reduction, symptom improvement and reductions in JAK2 V617F allele burden.
コンドロカルシン症は新規膝関節症の発症を予測する
Posted innews

コンドロカルシン症は新規膝関節症の発症を予測する

2つの大規模縦断研究は、基線時のコンドロカルシン症が長期フォローアップ中に放射線学的に確認された膝関節症の発症確率を約75%上昇させることを示しています。これは、カルシウム結晶沈着がOAの病態生理に寄与している可能性を示唆しています。
Two-thirds of ACL-injured Patients Avoid Surgery at 2 Years: Nationwide Registry Shows Rehab-first Strategy Often Works but Younger, Pivoting-sport Athletes and Meniscal Tears Predict Delayed Reconstruction
Posted innews Orthopedics Rehabilitation Medicine

Two-thirds of ACL-injured Patients Avoid Surgery at 2 Years: Nationwide Registry Shows Rehab-first Strategy Often Works but Younger, Pivoting-sport Athletes and Meniscal Tears Predict Delayed Reconstruction

A Norwegian registry study reports that 63% of patients with primary ACL injury initially managed non‑operatively remained non‑operative at two years; younger age, participation in pivoting sports and baseline meniscal injury increased risk of delayed ACL reconstruction, while 2‑year KOOS scores were similar.
SGLT2 Inhibitors Linked to Lower Parkinson’s Disease Risk Than Metformin in Type 2 Diabetes: Large Real‑World TriNetX Study Signals Class Neuroprotection
Posted inDiabetes & Endocrinology Neurology news

SGLT2 Inhibitors Linked to Lower Parkinson’s Disease Risk Than Metformin in Type 2 Diabetes: Large Real‑World TriNetX Study Signals Class Neuroprotection

A 20‑year TriNetX analysis of 913,428 T2DM patients found SGLT2 inhibitor use associated with a 28% lower Parkinson’s disease risk versus metformin (aHR 0.72), suggesting possible superior neuroprotection and prompting need for prospective confirmation.
SGLT-2 Inhibitors and Autoimmune Rheumatic Disease Risk Reduction in Type 2 Diabetes: Insights from a Korean Nationwide Cohort
Posted inDiabetes & Endocrinology news Rheumatology

SGLT-2 Inhibitors and Autoimmune Rheumatic Disease Risk Reduction in Type 2 Diabetes: Insights from a Korean Nationwide Cohort

A large South Korean cohort study suggests that sodium-glucose cotransporter-2 (SGLT-2) inhibitors reduce the incidence of autoimmune rheumatic diseases by 11% compared to sulfonylureas in adults with type 2 diabetes, indicating potential immunomodulatory benefits of SGLT-2 inhibitors beyond glycemic control.
Evaluating Self-Collected Urine and Vaginal Samples for HPV Genotyping in Cervical Cancer Screening Among Japanese Women
Posted inInfectious Diseases news Pathology & Lab Medicine

Evaluating Self-Collected Urine and Vaginal Samples for HPV Genotyping in Cervical Cancer Screening Among Japanese Women

This study assesses the feasibility and performance of using self-collected urine and vaginal samples with the BD Onclarity® HPV assay for cervical cancer screening in Japanese women with abnormal cytology, highlighting concordance and sensitivity metrics compared to clinician-collected cervical samples.