Preoperative Total Diet Replacement Safely Reduces Morbidity Risk and Preserves Muscle Mass in Colorectal Cancer Surgery

Preoperative Total Diet Replacement Safely Reduces Morbidity Risk and Preserves Muscle Mass in Colorectal Cancer Surgery

The CARE feasibility trial demonstrates that a preoperative low-energy total diet replacement program is safe and effective for colorectal cancer patients with excess weight. Significant weight loss was achieved without compromising lean muscle mass, showing potential for reduced postoperative complications and improved recovery.
Home-Based Gamma tACS Improves Cognitive Function and Daily Living in Alzheimer Disease: Results from a Randomized Clinical Trial

Home-Based Gamma tACS Improves Cognitive Function and Daily Living in Alzheimer Disease: Results from a Randomized Clinical Trial

A randomized clinical trial demonstrates that home-based gamma transcranial alternating current stimulation (tACS) over the precuneus safely improves cognitive outcomes and activities of daily living in patients with prodromal and mild Alzheimer disease, supported by neurophysiological evidence of brain engagement.
Shared Decision-Making with Otolaryngologists and Palliative Care Specialists Enhances Multidisciplinary Support in Advanced Oral Cavity Cancer

Shared Decision-Making with Otolaryngologists and Palliative Care Specialists Enhances Multidisciplinary Support in Advanced Oral Cavity Cancer

A prospective cohort study demonstrates that a structured shared decision-making (SOP) model significantly increases the utilization of multidisciplinary palliative care services for patients with stage IV oral cavity cancer, bridging the gap between curative intent and supportive care.
Standardizing the Digital Signal: How an Ontology of Early Warning Signs Can Predict Cytokine Release Syndrome

Standardizing the Digital Signal: How an Ontology of Early Warning Signs Can Predict Cytokine Release Syndrome

This article explores a landmark mixed-methods study establishing a digital biomarker ontology for the early detection of Cytokine Release Syndrome (CRS). By identifying core physiological markers, researchers aim to transform immunotherapy safety through continuous monitoring and predictive modeling.
Integrated Multidisciplinary Care Slashes Radiotherapy Interruptions in Head and Neck Cancer: Results from the SHINE-MDT Randomized Trial

Integrated Multidisciplinary Care Slashes Radiotherapy Interruptions in Head and Neck Cancer: Results from the SHINE-MDT Randomized Trial

A randomized clinical trial demonstrates that the SHINE-MDT framework significantly reduces radiotherapy interruptions and improves nutritional, psychological, and quality-of-life outcomes for patients with head and neck cancer, offering a new standard for holistic supportive care during intensive oncology treatments.
Next-Day HIV Viral Load Results Improve Time to Care for People Living with HIV but Show Limited Impact on Prevention Linkage

Next-Day HIV Viral Load Results Improve Time to Care for People Living with HIV but Show Limited Impact on Prevention Linkage

This randomized clinical trial explored if next-day HIV viral load results improve linkage to care. While overall linkage rates remained unchanged, the intervention significantly accelerated care initiation for individuals already living with HIV, suggesting a nuanced benefit for treatment over prevention pathways.