Medxy AI – Page 158

Tirzepatide’s Role in Obesity-Related HFpEF: Influence of BMI, Central Adiposity, and Weight Loss from the SUMMIT Trial

By MedXY 08/17/2025

Tirzepatide reduces heart failure risk in obese HFpEF patients regardless of BMI or central adiposity, with greater benefits on exercise capacity and symptom scores associated with higher BMI and weight loss.

Clinical Updates Neurology news Specialties

Long-Term Outcomes of Vagus Nerve Stimulation Paired With Upper Extremity Rehabilitation After Stroke

By MedXY 08/17/2025

This study evaluates the lasting benefits of vagus nerve stimulation combined with rehabilitation for stroke patients suffering from upper extremity impairments.

Neurology news Specialties

SUMMIT MAX Trial Validates Super Large Bore HiPoint System for Effective and Safe Aspiration Thrombectomy in Large Vessel Occlusion Stroke

By MedXY 08/17/2025

The SUMMIT MAX randomized trial demonstrates that the super large bore HiPoint reperfusion system is noninferior to the Vecta system in reperfusion success and safety for acute ischemic stroke due to large vessel occlusion.

Clinical Updates Neurology news Specialties

Impact of Prior Reperfusion Strategies on Early versus Late Direct Oral Anticoagulation in Ischemic Stroke: Insights from the ELAN Trial Subanalysis

By MedXY 08/17/2025

A subanalysis of the ELAN trial shows that prior reperfusion therapy does not alter the safety or efficacy outcomes of early versus late initiation of direct oral anticoagulants in ischemic stroke patients with atrial fibrillation.

Cardiology news Specialties

Thoracentesis in Acute Heart Failure: Insights from the TAP-IT Randomized Controlled Trial

By MedXY 08/17/2025

The TAP-IT trial found that additional thoracentesis in acute heart failure patients with pleural effusion did not improve days alive out of hospital, mortality, or length of stay compared to standard therapy alone.

Cardiology Clinical Updates news Specialties

Aficamten: A Breakthrough Oral Therapy for Obstructive Hypertrophic Cardiomyopathy Across Symptom Severity

By MedXY 08/17/2025

Aficamten significantly improves exercise capacity and symptoms in obstructive hypertrophic cardiomyopathy (HCM), demonstrating robust efficacy and safety in both mildly and severely symptomatic patients.

Cardiology news Specialties

Aficamten in Obstructive Hypertrophic Cardiomyopathy: Durable 48-Week Benefits and Insights on Combination Therapy

By MedXY 08/17/2025

Aficamten shows sustained obstruction relief, symptom improvement, and favorable cardiac remodeling over 48 weeks in obstructive hypertrophic cardiomyopathy, with safe discontinuation of disopyramide possible.

Cardiology Clinical Updates Nephrology news Specialties

Unraveling Molecular Links Between Chronic Kidney Disease and Heart Failure via the Plasma Proteome

By MedXY 08/17/2025

A comprehensive proteomic analysis from the ARIC study identifies plasma proteins linking kidney dysfunction to incident heart failure, highlighting potential biomarkers and therapeutic targets for HF prevention in CKD patients.

Cardiology Clinical Updates news Specialties

Left Atrial Volumetric/Mechanical Coupling Index in Heart Failure With Preserved Ejection Fraction

By MedXY 08/17/2025

This study explores the Left Atrial Coupling Index as a key predictor in heart failure patients with preserved ejection fraction.

Clinical Updates Neurology news Specialties

Antiplatelet vs Anticoagulant Therapy in Embolic Stroke of Undetermined Source: Insights from a Large Multicenter Cohort Study

By MedXY 08/17/2025

This study found no overall advantage of anticoagulation over antiplatelet therapy in ESUS patients but identified a potential benefit of anticoagulation in those with left ventricular injury.

Neurology news Specialties

Association of Medication Use and 8-Year Mortality Risk in Patients With Parkinson Disease

By MedXY 08/17/2025

This study explores medication use and its impact on 8-year mortality among patients with Parkinson disease, identifying potential drug repurposing candidates for treatment.

Neurology news Radiology Specialties

Noncontrast CT vs CT Perfusion Imaging in Acute Stroke: Comparative Insights from Recent Trials and Systematic Review

By MedXY 08/17/2025

Recent evidence from randomized trials and meta-analyses suggests that noncontrast CT (NCCT) offers comparable outcome prediction to CT perfusion (CTP) for selecting patients with acute ischemic stroke, including basilar artery occlusion, for endovascular therapy (EVT).

Cardiology Clinical Updates Neurology news Specialties

Evaluating Thigh-High Compression Stockings in Preventing Vasovagal Syncope Recurrence: Insights from a Randomized Sham-Controlled Trial

By MedXY 08/17/2025

A randomized sham-controlled trial found that thigh-high elastic compression stockings did not significantly reduce vasovagal syncope recurrence or improve syncope-free survival, though fewer episodes occurred during active stocking use.

Cardiology Specialties

Optimizing Anticoagulant Therapy in Frail Elderly AF Patients: Insights from the COMBINE-AF Substudy

By MedXY 08/17/2025

Switching frail, elderly atrial fibrillation patients from warfarin to standard-dose DOAC reduced stroke, fatal and intracranial bleeding, and death, though gastrointestinal bleeding increased. Major bleeding and net clinical outcome remained similar.

Cardiology news Specialties

Vutrisiran’s Impact on Cardiac Function and Outcomes in Transthyretin Amyloid Cardiomyopathy: Insights from HELIOS-B

By MedXY 08/17/2025

Vutrisiran improves cardiac structure, function, and biomarkers, reducing mortality and cardiovascular events in transthyretin amyloid cardiomyopathy over 30 months.

Neurology Specialties

Unexplained Early Neurologic Deterioration After Thrombectomy in Stroke: Incidence, Risk Factors, and Mechanistic Insights

By MedXY 08/17/2025

Unexplained early neurologic deterioration (unEND) affects about 10% of ischemic stroke patients after thrombectomy, linked to age, anesthesia, delayed reperfusion, and infarct growth beyond hypoperfused tissue.

Clinical Updates Neurology Specialties

Mechanical Thrombectomy in Distal Medium MCA Occlusion: Impact of Pre-Stroke Low-Dose Aspirin on Efficacy and Safety

By MedXY 08/17/2025

Pre-stroke low-dose aspirin in distal medium vessel occlusion stroke patients undergoing mechanical thrombectomy is linked to improved 90-day functional outcomes and reduced mortality without increased symptomatic hemorrhage risk.

Clinical Updates Neurology news Specialties

Edaravone Dexborneol in Acute Ischemic Stroke: Real-World Evidence of Enhanced Functional Recovery and Safety

By MedXY 08/17/2025

In a large multicenter cohort study, edaravone dexborneol treatment in acute ischemic stroke patients was linked to improved 90-day functional outcomes without increased adverse events, supporting its clinical utility.

Cardiology Specialties

Evaluating Aspirin Plus Rivaroxaban versus Rivaroxaban Alone to Prevent Venous Stent Thrombosis in Post-Thrombotic Syndrome: Insights from the ARIVA Trial

By MedXY 08/17/2025

The ARIVA trial found no superior benefit of adding aspirin to rivaroxaban over rivaroxaban alone in preventing venous stent thrombosis within 6 months post-intervention in post-thrombotic syndrome patients, with both regimens showing high patency and safety.

Cardiology news Specialties

Risks and Realities of Withdrawing Heart Failure Medications After Ejection Fraction Improvement

By MedXY 08/17/2025

Withdrawal of renin-angiotensin inhibitors and mineralocorticoid receptor antagonists in patients with heart failure and improved ejection fraction significantly increases 1-year cardiovascular mortality and hospitalization risks; beta-blocker withdrawal shows varied effects based on EF.

Tirzepatide’s Role in Obesity-Related HFpEF: Influence of BMI, Central Adiposity, and Weight Loss from the SUMMIT Trial

Long-Term Outcomes of Vagus Nerve Stimulation Paired With Upper Extremity Rehabilitation After Stroke

SUMMIT MAX Trial Validates Super Large Bore HiPoint System for Effective and Safe Aspiration Thrombectomy in Large Vessel Occlusion Stroke

Impact of Prior Reperfusion Strategies on Early versus Late Direct Oral Anticoagulation in Ischemic Stroke: Insights from the ELAN Trial Subanalysis

Thoracentesis in Acute Heart Failure: Insights from the TAP-IT Randomized Controlled Trial

Aficamten: A Breakthrough Oral Therapy for Obstructive Hypertrophic Cardiomyopathy Across Symptom Severity

Aficamten in Obstructive Hypertrophic Cardiomyopathy: Durable 48-Week Benefits and Insights on Combination Therapy

Unraveling Molecular Links Between Chronic Kidney Disease and Heart Failure via the Plasma Proteome

Left Atrial Volumetric/Mechanical Coupling Index in Heart Failure With Preserved Ejection Fraction

Antiplatelet vs Anticoagulant Therapy in Embolic Stroke of Undetermined Source: Insights from a Large Multicenter Cohort Study

Association of Medication Use and 8-Year Mortality Risk in Patients With Parkinson Disease

Noncontrast CT vs CT Perfusion Imaging in Acute Stroke: Comparative Insights from Recent Trials and Systematic Review

Evaluating Thigh-High Compression Stockings in Preventing Vasovagal Syncope Recurrence: Insights from a Randomized Sham-Controlled Trial

Optimizing Anticoagulant Therapy in Frail Elderly AF Patients: Insights from the COMBINE-AF Substudy

Vutrisiran’s Impact on Cardiac Function and Outcomes in Transthyretin Amyloid Cardiomyopathy: Insights from HELIOS-B

Unexplained Early Neurologic Deterioration After Thrombectomy in Stroke: Incidence, Risk Factors, and Mechanistic Insights

Mechanical Thrombectomy in Distal Medium MCA Occlusion: Impact of Pre-Stroke Low-Dose Aspirin on Efficacy and Safety

Edaravone Dexborneol in Acute Ischemic Stroke: Real-World Evidence of Enhanced Functional Recovery and Safety

Evaluating Aspirin Plus Rivaroxaban versus Rivaroxaban Alone to Prevent Venous Stent Thrombosis in Post-Thrombotic Syndrome: Insights from the ARIVA Trial

Risks and Realities of Withdrawing Heart Failure Medications After Ejection Fraction Improvement

Safety First: Concurrent Metastases-Directed Stereotactic Radiotherapy and Biological Therapy Show Low Risk of Severe Adverse Events

Environmental Cardiotoxicity: PM2.5 and Ozone Exposure Double the Risk of Cardiac Dysfunction in Breast Cancer Patients

Docetaxel Rechallenge vs Cabazitaxel: Choosing the Right Taxane Sequence in Metastatic Castration-Resistant Prostate Cancer

Moving Beyond Birthdays: Five-Year Absolute Risk-Based Screening Outperforms Age-Based Mammography