Medxy AI – Page 143

ENHANCE-3 Trial: Evaluating Magrolimab Addition to Venetoclax and Azacitidine in Untreated AML Unfit for Intensive Chemotherapy

By MedXY 08/29/2025

The ENHANCE-3 phase 3 trial assessed whether adding magrolimab to venetoclax and azacitidine improves outcomes in untreated AML patients unfit for intensive chemotherapy, finding no survival benefit and a higher rate of fatal adverse events with magrolimab.

$Five-Year Outcomes of FCARH143: A Fully Human BCMA CAR-T Therapy in Relapsed/Refractory Multiple Myeloma$

Clinical Updates Hematology-Oncology Specialties

Five-Year Outcomes of FCARH143: A Fully Human BCMA CAR-T Therapy in Relapsed/Refractory Multiple Myeloma

By MedXY 08/29/2025

FCARH143, a fully human BCMA-directed CAR-T cell therapy, shows remarkable long-term efficacy and manageable safety profile in heavily pretreated relapsed/refractory multiple myeloma patients over 5 years.

Allergy & Immunology Hematology-Oncology Specialties

Clonal Hematopoiesis and Its Link to Severe Cytokine Release Syndrome in CAR T-Cell Therapy Recipients

By MedXY 08/29/2025

Clonal hematopoiesis (CH) occurs frequently in patients receiving CD19 or BCMA CAR T therapy and correlates with a higher risk of severe cytokine release syndrome (CRS), suggesting CH as a potential biomarker for CRS risk and a target for prophylactic strategies.

Hematology-Oncology Specialties

Tandem CD19/CD22 CAR T-Cell Therapy: A Promising Advance for High-Risk Pediatric and AYA r/r B-ALL

By MedXY 08/29/2025

Tandem CD19/CD22 CAR T-cell therapy shows encouraging safety and efficacy in heavily pretreated children and young adults with relapsed/refractory B-ALL, particularly when combined with consolidative hematopoietic stem cell transplantation.

Hematology-Oncology Specialties

Proinflammatory Cytokines and Low Peripheral Blood Counts Predict Poor Outcomes after CD19 CAR-T Therapy in Acute Lymphoblastic Leukemia

By MedXY 08/29/2025

Elevated proinflammatory cytokines combined with low peripheral blood counts early after CD19 CAR-T cell infusion correlate with poor treatment response and severe toxicity in relapsed/refractory B-ALL, highlighting inflammation as a key modifiable factor for improving outcomes.

Hematology-Oncology Specialties

T-ICAHT: A New Grading System for Thrombocytopenia After CAR T-cell Therapy with Prognostic Significance

By MedXY 08/29/2025

A novel grading system, T-ICAHT, quantifies thrombocytopenia after CAR T-cell therapy, revealing its prevalence and prognostic impact, highlighting its value in patient management and outcome prediction across hematologic malignancies.

$ZUMA-8 Trial: Advancing CAR T-Cell Therapy with Brexucabtagene Autoleucel in Relapsed/Refractory Chronic Lymphocytic Leukemia$

Clinical Updates Hematology-Oncology news Specialties

ZUMA-8 Trial: Advancing CAR T-Cell Therapy with Brexucabtagene Autoleucel in Relapsed/Refractory Chronic Lymphocytic Leukemia

By MedXY 08/29/2025

The ZUMA-8 phase 1 study evaluates the safety and efficacy of brexucabtagene autoleucel, a CD19-directed CAR T-cell therapy, in relapsed/refractory CLL, showing promising response rates and manageable safety profiles, especially in patients with low tumor burden.

$Modakafusp alfa in Relapsed/Refractory Multiple Myeloma: Insights from a Phase 2 Randomized Dose Optimization Study$

Hematology-Oncology Specialties

Modakafusp alfa in Relapsed/Refractory Multiple Myeloma: Insights from a Phase 2 Randomized Dose Optimization Study

By MedXY 08/29/2025

This phase 2 trial evaluated modakafusp alfa, a novel immunocytokine targeting CD38+ cells, in heavily pretreated relapsed/refractory multiple myeloma, showing promising efficacy and manageable toxicity despite early termination.

$Revumenib: A New Menin Inhibitor Offering Hope for NPM1-Mutated Relapsed/Refractory AML$

Hematology-Oncology Specialties

Revumenib: A New Menin Inhibitor Offering Hope for NPM1-Mutated Relapsed/Refractory AML

By MedXY 08/29/2025

The phase 2 AUGMENT-101 study demonstrates that revumenib, a selective menin inhibitor, induces meaningful remissions and enables stem cell transplantation in heavily pretreated, older patients with relapsed or refractory NPM1-mutated AML, addressing a critical unmet need.

Diabetes & Endocrinology Specialties

CagriSema: A Breakthrough Combination Therapy for Weight Loss in Adults with Overweight or Obesity

By MedXY 08/28/2025

A phase 3a trial shows coadministered cagrilintide and semaglutide (CagriSema) significantly reduce body weight up to 20.4% over 68 weeks in adults with overweight or obesity, with manageable side effects, offering a promising new option for obesity management.

Hematology-Oncology Specialties

Pemigatinib: A Breakthrough Targeted Therapy for Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangements

By MedXY 08/28/2025

Pemigatinib demonstrates high efficacy and manageable toxicity in treating MLN-FGFR1, especially in chronic-phase patients, addressing a critical unmet need in this aggressive neoplasm.

Pediatrics Public Health Specialties

Promising Immunogenicity and Safety of the Live-Attenuated Intranasal RSV Vaccine in Infants and Toddlers

By MedXY 08/28/2025

This phase I/II trial demonstrates that the live-attenuated intranasal RSV vaccine (RSVt) is immunogenic and well-tolerated in infants and toddlers, offering a potential new preventive option against RSV infection.

Clinical Updates news Psychiatry Specialties

Optimizing Smoking Cessation in Major Depressive Disorder: Varenicline Outperforms Bupropion and Nicotine Patch with Comparable Safety

By MedXY 08/28/2025

This analysis reveals that varenicline is the most effective and safe pharmacotherapy for smoking cessation in individuals with current or past major depressive disorder, outperforming bupropion and nicotine patches with no increased neuropsychiatric risks.

AI Psychiatry Specialties

Evaluating the Role of AI Tools in Pharmacy Students’ OSCE Performance and Anxiety: Insights from a Randomized Controlled Trial

By MedXY 08/27/2025

A randomized trial assessing AI-generated study materials revealed no significant impact on pharmacy students’ objective structured clinical examination scores or test anxiety levels, highlighting the need for further research on long-term educational outcomes.

Allergy & Immunology Clinical Updates news Respiratory Specialties

Rentosertib: The First AI-Discovered TNIK Inhibitor Shows Promise in Idiopathic Pulmonary Fibrosis Phase 2a Trial

By MedXY 08/27/2025

Rentosertib, an AI-designed TNIK inhibitor, demonstrated safety and preliminary efficacy in idiopathic pulmonary fibrosis in a randomized phase 2a trial, marking a milestone in AI-driven drug development for progressive lung diseases.

AI Psychiatry Specialties

Enhancing Depression Care in College Students: AI Chatbots with Social Cues Show Superior Effectiveness

By MedXY 08/27/2025

A 16-week randomized trial demonstrates that AI chatbots with high-social-cue design significantly reduce depression and anxiety symptoms in college students compared to text-only chatbots, improving adherence, satisfaction, and therapeutic alliance.

OB/GYN & Women's Health Oncology Specialties

ChatGPT-4o versus Gynecologic Oncologists in Endometrial Cancer Patient Communication: A Prospective Comparative Study

By MedXY 08/27/2025

This study compares ChatGPT-4o and gynecologic oncologists in addressing endometrial cancer patient questions, showing superior AI accuracy, empathy, and completeness, though lengthy responses may challenge patient comprehension.

AI Family Medicine & Nutrition news Specialties

AI Versus Family Physicians: Evaluating ChatGPT-4o’s Responses to Common Primary Care Queries

By MedXY 08/27/2025

This study compares ChatGPT-4o and family physicians in answering 200 common primary care questions, revealing AI’s superior performance in appropriateness, accuracy, comprehensiveness, and empathy, highlighting its potential in enhancing primary care.

Family Medicine & Nutrition news Pediatrics Specialties

Micronutrient Supplementation Modulates Gut Microbiome in Children with ADHD: Insights from the MADDY Study

By MedXY 08/27/2025

The MADDY study reveals that micronutrient supplementation in children with ADHD alters gut microbial diversity and composition, notably increasing beneficial butyrate-producing bacteria, potentially underpinning improved behavioral outcomes.

Clinical Updates Neurology news Specialties

Sodium Benzoate as a Promising Treatment for Amnestic Mild Cognitive Impairment: Evidence from a Randomized Controlled Trial

By MedXY 08/27/2025

A 24-week randomized, double-blind trial shows sodium benzoate, a D-amino acid oxidase inhibitor, improves short-term memory in patients with amnestic mild cognitive impairment, suggesting a potential therapeutic role with a favorable safety profile.

ENHANCE-3 Trial: Evaluating Magrolimab Addition to Venetoclax and Azacitidine in Untreated AML Unfit for Intensive Chemotherapy

Five-Year Outcomes of FCARH143: A Fully Human BCMA CAR-T Therapy in Relapsed/Refractory Multiple Myeloma

Clonal Hematopoiesis and Its Link to Severe Cytokine Release Syndrome in CAR T-Cell Therapy Recipients

Tandem CD19/CD22 CAR T-Cell Therapy: A Promising Advance for High-Risk Pediatric and AYA r/r B-ALL

Proinflammatory Cytokines and Low Peripheral Blood Counts Predict Poor Outcomes after CD19 CAR-T Therapy in Acute Lymphoblastic Leukemia

T-ICAHT: A New Grading System for Thrombocytopenia After CAR T-cell Therapy with Prognostic Significance

ZUMA-8 Trial: Advancing CAR T-Cell Therapy with Brexucabtagene Autoleucel in Relapsed/Refractory Chronic Lymphocytic Leukemia

Modakafusp alfa in Relapsed/Refractory Multiple Myeloma: Insights from a Phase 2 Randomized Dose Optimization Study

Revumenib: A New Menin Inhibitor Offering Hope for NPM1-Mutated Relapsed/Refractory AML

CagriSema: A Breakthrough Combination Therapy for Weight Loss in Adults with Overweight or Obesity

Pemigatinib: A Breakthrough Targeted Therapy for Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangements

Promising Immunogenicity and Safety of the Live-Attenuated Intranasal RSV Vaccine in Infants and Toddlers

Optimizing Smoking Cessation in Major Depressive Disorder: Varenicline Outperforms Bupropion and Nicotine Patch with Comparable Safety

Evaluating the Role of AI Tools in Pharmacy Students’ OSCE Performance and Anxiety: Insights from a Randomized Controlled Trial

Rentosertib: The First AI-Discovered TNIK Inhibitor Shows Promise in Idiopathic Pulmonary Fibrosis Phase 2a Trial

ChatGPT-4o versus Gynecologic Oncologists in Endometrial Cancer Patient Communication: A Prospective Comparative Study

AI Versus Family Physicians: Evaluating ChatGPT-4o’s Responses to Common Primary Care Queries

Micronutrient Supplementation Modulates Gut Microbiome in Children with ADHD: Insights from the MADDY Study

Sodium Benzoate as a Promising Treatment for Amnestic Mild Cognitive Impairment: Evidence from a Randomized Controlled Trial

Thyroidectomy in Older Adults: Are Increased Relative Risks a Barrier to Surgical Safety?

Expanding the Thrombolysis Window: Tenecteplase Improves Outcomes in Late-Window Non-Large Vessel Occlusion Stroke

Combined ACL and ALL Reconstruction Significantly Reduces Graft Failure in High-Risk Young Patients: 5-Year RCT Evidence

Minutes Matter: How Modern Medicine is Winning the Race Against Heart Attacks