Impact of Structural Cardiac Abnormalities on the Efficacy and Safety of Sacubitril/Valsartan in Patients with Mildly Reduced or Preserved Ejection Fraction and Worsening Heart Failure: Insights from the PARAGLIDE-HF Trial
Posted inCardiology Clinical Updates news Specialties

Impact of Structural Cardiac Abnormalities on the Efficacy and Safety of Sacubitril/Valsartan in Patients with Mildly Reduced or Preserved Ejection Fraction and Worsening Heart Failure: Insights from the PARAGLIDE-HF Trial

The PARAGLIDE-HF trial demonstrates that sacubitril/valsartan significantly reduces NT-proBNP in patients with LVEF >40% and worsening heart failure, regardless of left ventricular hypertrophy or left atrial enlargement, but patients with both abnormalities face higher hyperkalemia risk.
Nature: Influenza and SARS‑CoV‑2 can awaken dormant breast cancer cells and trigger lung metastasis
Posted inClinical Updates Infectious Diseases news Oncology Specialties

Nature: Influenza and SARS‑CoV‑2 can awaken dormant breast cancer cells and trigger lung metastasis

A Nature paper shows influenza and SARS‑CoV‑2 lung infections can reactivate dormant disseminated breast cancer cells (DCCs) via IL‑6 and CD4+ T‑cell–mediated mechanisms, with concordant human data linking SARS‑CoV‑2 infection to higher cancer‑related mortality and pulmonary metastasis risk.