Berberine and Cinnamon Synergy: A Promising Adjunct Therapy for Improving Glycemic Control and LDL Cholesterol in Type 2 Diabetes
Posted inClinical Updates Diabetes & Endocrinology Specialties

Berberine and Cinnamon Synergy: A Promising Adjunct Therapy for Improving Glycemic Control and LDL Cholesterol in Type 2 Diabetes

A 12-week randomized controlled trial demonstrated that supplementation with berberine plus cinnamon significantly lowers fasting blood sugar, HbA1c, and LDL cholesterol in patients with type 2 diabetes, offering potential for improved cardiometabolic risk management.
Butyrate-Producing Clostridium butyricum: A Direct Interactor with Colorectal Cancer Cells that Reverses Immune Suppression and Enhances Checkpoint Inhibitor Efficacy
Posted inClinical Updates Family Medicine & Nutrition Gastroenterology news Oncology Specialties

Butyrate-Producing Clostridium butyricum: A Direct Interactor with Colorectal Cancer Cells that Reverses Immune Suppression and Enhances Checkpoint Inhibitor Efficacy

Recent research uncovers that the probiotic Clostridium butyricum directly interacts with colorectal cancer cells to inhibit immune suppression via the secD-GRP78 axis, restoring CD8+ T cell antitumor function and enhancing PD-1 inhibitor therapy.
Predictive Factors for Diabetes Outcomes One Year After Total Pancreatectomy with Islet Autotransplantation: Insights from a Large Multicenter Study
Posted inClinical Updates Diabetes & Endocrinology General Surgery Specialties

Predictive Factors for Diabetes Outcomes One Year After Total Pancreatectomy with Islet Autotransplantation: Insights from a Large Multicenter Study

This multicenter study identifies key predictors of diabetes outcomes one year after total pancreatectomy with islet autotransplantation, highlighting the importance of preoperative glycemic control and age in achieving insulin independence and maintaining islet graft function.
Advancing Radiotherapy in High-Grade Glioma: Targeted Volume Reduction with Hypofractionated Simultaneous Boost IMRT
Posted inClinical Updates Oncology Radiology Specialties

Advancing Radiotherapy in High-Grade Glioma: Targeted Volume Reduction with Hypofractionated Simultaneous Boost IMRT

A randomized trial demonstrates that modified target delineation integrating multimodal MRI and white matter tractography with moderately hypofractionated radiotherapy achieves comparable survival outcomes to standard IMRT while reducing irradiation volumes in high-grade glioma patients.
PANLAR 2025 Recommendations for Polyarticular Juvenile Idiopathic Arthritis in Latin America — Practical, Evidence-Based Guidance for Resource-Variable Settings
Posted inAllergy & Immunology Clinical Updates news Rheumatology Specialties

PANLAR 2025 Recommendations for Polyarticular Juvenile Idiopathic Arthritis in Latin America — Practical, Evidence-Based Guidance for Resource-Variable Settings

PANLAR’s 2025 evidence-based recommendations for non-systemic polyarticular JIA emphasize early treat-to-target care using methotrexate, targeted escalation to biologics when needed, region-sensitive alternatives (leflunomide, triple nbDMARD therapy), and limited steroid bridging to improve outcomes in Latin America.
Association of Hysterectomy With Hypertension Incidence in Korean Women: Insights from a Nationwide Cohort Study
Posted inCardiology Clinical Updates General Surgery OB/GYN & Women's Health Specialties

Association of Hysterectomy With Hypertension Incidence in Korean Women: Insights from a Nationwide Cohort Study

This nationwide Korean cohort study found that hysterectomy is associated with a modestly increased risk of developing hypertension in women aged 40 to 59 years, particularly in those with elevated post-surgical hemoglobin levels and after adnexa-sparing procedures.
Self-Monitoring of Blood Pressure With Mobile App Feedback Enhances Control and Adherence in Uncontrolled Hypertension: Insights From the SMART-BP Trial and Broader Evidence
Posted inAI Cardiology Clinical Updates Specialties

Self-Monitoring of Blood Pressure With Mobile App Feedback Enhances Control and Adherence in Uncontrolled Hypertension: Insights From the SMART-BP Trial and Broader Evidence

The SMART-BP trial demonstrates that a mobile app providing tailored feedback significantly improves systolic blood pressure reduction and drug adherence compared to self-monitoring alone, highlighting innovative digital solutions in hypertension management.