Clinical Updates – Page 19

Reevaluating Beta-Blocker Therapy Post-Myocardial Infarction with Preserved Ejection Fraction: Insights from Recent Trials and Meta-Analyses

By MedXY 09/02/2025

Recent evidence challenges the routine use of long-term beta-blockers after myocardial infarction in patients with preserved ejection fraction, highlighting comparable outcomes with or without therapy and raising safety and efficacy considerations in contemporary practice.

Cardiology Clinical Updates news Specialties

Decline in LVEF Predicts Ventricular Tachyarrhythmias and Mortality in HFpEF: Insights from the CHART-2 Study

By MedXY 09/02/2025

A mild-to-significant decline in left ventricular ejection fraction (LVEF) in heart failure with preserved ejection fraction (HFpEF) signals higher risks of lethal arrhythmias, sudden cardiac death, and mortality, underscoring the need for ongoing LVEF monitoring.

Cardiology Clinical Updates news Specialties

Volenrelaxin in HFpEF: Unexpected Worsening of Congestion Despite Improvements in Left Atrial Function

By MedXY 09/02/2025

This phase 2 trial shows that volenrelaxin, a long-acting relaxin analog, failed to improve overall congestion or kidney function in HFpEF patients and was linked to worsening congestion and safety signals, despite modest left atrial function improvement at low dose.

Cardiology Clinical Updates news Specialties

Low-Dose Digoxin Enhances Cardiac Function in Heart Failure with Preserved EF and Atrial Fibrillation: Insights from the RATE-AF Trial

By MedXY 09/02/2025

The RATE-AF trial demonstrates that low-dose digoxin significantly improves systolic function and symptoms in patients with heart failure, preserved ejection fraction, and permanent atrial fibrillation compared to beta-blockers, with fewer adverse events.

Cardiology Clinical Updates Gastroenterology Specialties

Routine Helicobacter pylori Screening Post-Myocardial Infarction: Insights from the HELP-MI SWEDEHEART Trial

By MedXY 09/02/2025

Routine H. pylori screening after acute myocardial infarction does not significantly reduce upper gastrointestinal bleeding incidence; targeted screening in anemia or kidney failure subgroups may offer benefit.

Cardiology Clinical Updates Gastroenterology news Specialties

Routine Helicobacter pylori Screening Post-Myocardial Infarction: Insights from the HELP-MI SWEDEHEART Trial

By MedXY 09/02/2025

In a large Swedish cluster-randomized trial, routine Helicobacter pylori screening after acute myocardial infarction did not significantly reduce upper gastrointestinal bleeding, though high-risk subgroups may benefit.

AI Clinical Updates news Specialties

Harnessing AI in Clinical Documentation: Evaluating Large Language Model-Generated Hospital Discharge Summaries

By MedXY 09/02/2025

A study comparing large language model-generated versus physician-generated discharge summaries found comparable quality and safety, suggesting AI-assisted documentation could reduce clinical burden without compromising patient care.

Clinical Updates news Nursing & care Orthopedics Specialties

Revolutionizing Osteoporosis Screening in High-Risk Older Men: The Impact of a Remote Bone Health Service

By MedXY 09/02/2025

A cluster randomized trial demonstrates a centralized remote bone health service significantly improves osteoporosis screening, treatment initiation, adherence, and bone density outcomes in high-risk older men compared to usual care.

Clinical Updates Diabetes & Endocrinology news Specialties

Triple Therapy Enhances Glycemic Control in Cystic Fibrosis Patients with Abnormal Glucose Tolerance

By MedXY 09/02/2025

Elexacaftor-tezacaftor-ivacaftor significantly improves glucose tolerance, lowers A1c and sweat chloride levels, and demonstrates safety in cystic fibrosis patients with impaired glucose tolerance or cystic fibrosis-related diabetes over 48 weeks.

Allergy & Immunology Clinical Updates Dermatology Gastroenterology

Alopecia Areata Linked to Elevated Risk of Microscopic Colitis and Other Immune-Mediated GI Disorders: Clinical Insights

By MedXY 09/01/2025

A large retrospective cohort study identifies a significant association between alopecia areata and increased risks of microscopic colitis, celiac disease, Crohn’s disease, eosinophilic esophagitis, and ulcerative colitis, highlighting the need for gastrointestinal screening in affected patients.

AI Clinical Updates news Orthopedics Specialties

Personalized Gait Retraining: A Promising Conservative Approach to Medial Knee Osteoarthritis

By MedXY 09/01/2025

A randomized trial shows that personalized foot progression angle modifications significantly reduce medial knee pain and slow cartilage degeneration in medial compartment knee osteoarthritis.

Clinical Updates news Oncology

Distinct Clinical and Genomic Profiles of Anogenital Basal Cell Carcinomas Highlight Higher Recurrence Risks

By MedXY 09/01/2025

Anogenital basal cell carcinomas (BCCs) represent a rare subtype with unique genomic features and a higher recurrence rate compared to UV-related BCCs. This French cohort study elucidates their clinical characteristics, lichen sclerosus association, and dependence on the sonic hedgehog pathway, informing tailored management strategies.

Clinical Updates OB/GYN & Women's Health Oncology Specialties

Everolimus Plus Carboplatin: A Promising Combination for Advanced Triple-Negative Breast Cancer

By MedXY 09/01/2025

A phase 2 study shows adding everolimus to carboplatin significantly improves progression-free survival in advanced TNBC with manageable safety profile, indicating a potential new treatment avenue.

Clinical Updates news Ophthalmology Specialties

Low-Level Light Therapy: A New Frontier in Preventing Dry Eye After Cataract Surgery

By MedXY 09/01/2025

Low-level light therapy, administered perioperatively, significantly reduces dry eye symptoms and preserves ocular surface integrity after cataract surgery, offering a noninvasive adjunct to standard care.

Cardiology Clinical Updates Radiology Specialties

FFR-Guided Complete Revascularization Enhances Outcomes in NSTEMI with Multivessel Disease: Insights from the SLIM Trial

By MedXY 09/01/2025

The SLIM trial demonstrates that fractional flow reserve–guided complete revascularization during the index procedure significantly reduces major adverse events at one year in patients with NSTEMI and multivessel disease, primarily by lowering repeat revascularizations.

Clinical Updates Infectious Diseases news Public Health Specialties

Evaluating RSV Vaccine Effectiveness Against Hospitalization in US Adults Aged 60 and Older Over Two Seasons

By MedXY 09/01/2025

A large multicenter study demonstrates that a single dose of RSV vaccine reduces hospitalization risk by 58% among adults aged 60+, with lower effectiveness in immunocompromised and cardiovascular patients.

Cardiology Clinical Updates news Specialties

Semaglutide and Tirzepatide Significantly Reduce Hospitalization and Mortality in Cardiometabolic HFpEF Patients: Real-World Evidence

By MedXY 08/31/2025

Real-world analysis shows semaglutide and tirzepatide reduce hospitalization for heart failure or all-cause mortality by over 40% in patients with cardiometabolic HFpEF, with no significant difference between the two drug options.

Cardiology Clinical Updates news Specialties

Personalized Accelerated Physiologic Pacing Shows Promise in HFpEF: Insights from the myPACE Trial Extension

By MedXY 08/31/2025

Personalized increased pacing rates in patients with HFpEF and physiologic pacemakers may reduce adverse events and improve event-free survival, per a 4-year observational extension of the myPACE randomized trial.

Cardiology Clinical Updates General Surgery news Specialties

Reducing Infection Risk in Repeat CIED Surgery with Iodine-Impregnated Drapes: Insights from a Randomized Clinical Trial

By MedXY 08/31/2025

A randomized trial demonstrates that iodine-impregnated drapes significantly reduce pocket contamination and cardiac implantable electronic device infections in repeat surgeries, offering a simple, cost-effective prophylactic intervention.

Clinical Updates General Surgery news Psychiatry Specialties

Preoperative Anxiety as a Key Predictor of Postoperative Delirium: Insights from a Year-Long Cohort Study

By MedXY 08/31/2025

A prospective study reveals that nearly 20% of surgical patients experience postoperative delirium in the PACU, with elevated preoperative anxiety significantly increasing this risk. Implementation of a brain health care bundle improves management of perioperative symptoms.