news – Page 85 – Medxy AI

Metabolic Syndrome Increases Parkinson’s Disease Risk: Implications for Clinical Practice and Prevention

By MedXY 08/30/2025

A large cohort study reveals that metabolic syndrome significantly raises Parkinson’s disease risk by 39%, with even greater risk in genetically predisposed individuals, highlighting the importance of metabolic health management in PD prevention.

Cardiology news Radiology Specialties

Epicardial Adipose Tissue as a Predictor of New-Onset Atrial Fibrillation: Insights from a Danish Population Cohort

By MedXY 08/30/2025

This Danish cohort study demonstrates that increased epicardial adipose tissue volume independently elevates the risk of new-onset atrial fibrillation, highlighting the importance of fat distribution beyond BMI in cardiovascular risk assessment.

Cardiology Clinical Updates news Specialties

Five Key Lessons From the DIGIT-HF Trial: Revisiting Digitoxin in HFrEF Management

By MedXY 08/30/2025

The DIGIT-HF trial sheds new light on digitoxin's role in heart failure with reduced ejection fraction, revealing safety, efficacy, and clinical implications despite contemporary therapies.

Cardiology news Specialties

Digitoxin Revisited: A Renewed Therapeutic Avenue for Advanced Heart Failure Patients

By MedXY 08/30/2025

The DIGIT-HF trial reveals that adding low-dose digitoxin to standard heart failure treatment reduces hospitalization and all-cause mortality in symptomatic HFrEF patients, highlighting a potential resurgence for this historic cardiac glycoside under strict dosing protocols.

Cardiology news Specialties

Reevaluating Antihypertensive Therapy in Frail Elderly Nursing Home Residents: Insights from the RETREAT-FRAIL Trial

By MedXY 08/30/2025

The RETREAT-FRAIL trial found no survival benefit from progressively reducing antihypertensive medications in frail nursing home residents aged ≥80 with controlled blood pressure, supporting individualized treatment strategies.

Diabetes & Endocrinology news OB/GYN & Women's Health Specialties

Impact of Maternal Trace Element Levels on Neonatal Growth Among Diabetic and Non-Diabetic Pregnancies

By MedXY 08/30/2025

A case–control study reveals that elevated copper levels in diabetic pregnant women negatively affect newborn weight and head circumference, while chromium correlates positively with birth length. Smoking exposure adversely impacts infants’ weight, underscoring maternal trace element status and lifestyle as key determinants of neonatal outcomes.

Allergy & Immunology Clinical Updates news Oncology Specialties

Tumor Microenvironment-Responsive Mn-Based Nanoplatform Activates cGAS-STING Pathway Coupled with Metabolic Interference for Enhanced Antitumor Therapy

By MedXY 08/30/2025

A novel Mn-based nanoplatform, LT@MnO@MON-HA (LMMH), responsive to tumor microenvironment triggers metabolic disruption and robust cGAS-STING activation, potentiating chemodynamic therapy and immunotherapy for improved tumor suppression.

Clinical Updates news Oncology Radiology Specialties

Real-time MRI Visualization of Tumor Acidosis: A Novel Predictor of Therapeutic Efficacy Using a Manganese Sulfide-Based Nanoplatform

By MedXY 08/30/2025

A manganese sulfide nanoplatform loaded with proton pump inhibitor enables real-time MRI visualization of tumor acidosis, providing early prediction of therapeutic efficacy and potential for improved cancer management.

Allergy & Immunology Clinical Updates news Oncology Specialties

Manganese: A Potent Catalyst Enhancing Cancer Immunotherapy

By MedXY 08/30/2025

Manganese and its nanoparticles play a pivotal role in cancer immunotherapy by modulating immune pathways, reshaping the tumor microenvironment, and serving as effective adjuvants and drug carriers, offering promising avenues to overcome current therapeutic challenges.

Clinical Updates Dermatology Gastroenterology news Specialties

Unveiling the Gut-Skin Axis: Microbiota-Driven Crosstalk with Promising Therapeutic Horizons

By MedXY 08/30/2025

The gut-skin axis embodies a bidirectional microbiota-influenced dialogue pivotal for tissue homeostasis and disease. Understanding this interplay reveals innovative approaches to manage inflammatory skin and gut diseases.

Diabetes & Endocrinology news Specialties

Tirzepatide Enhances Quality of Life in Adults with Obesity or Overweight: Insights from the SURMOUNT-3 Trial

By MedXY 08/30/2025

Tirzepatide significantly improves health-related quality of life alongside weight reduction in adults with obesity or overweight, especially those experiencing physical function limitations, according to SURMOUNT-3 trial results.

Diabetes & Endocrinology news Specialties

Tirzepatide Significantly Lowers Predicted 10-Year Type 2 Diabetes Risk in Chinese Adults with Overweight or Obesity: Insights from the SURMOUNT-CN Trial

By MedXY 08/30/2025

Post hoc analysis of the SURMOUNT-CN trial shows tirzepatide markedly reduces the 10-year predicted risk of type 2 diabetes in Chinese individuals with overweight or obesity, regardless of baseline BMI or prediabetes status.

Emergency Medicine Infectious Diseases news Pediatrics Public Health Specialties

Enhancing Early Risk Stratification of Severe Childhood Febrile Illness in Rural Asia Using sTREM1 Biomarker

By MedXY 08/30/2025

A multicountry study across Asia demonstrates soluble TREM1's superior accuracy over traditional clinical signs in predicting severe febrile illness in children, potentially transforming triage in resource-limited settings.

Cardiology Family Medicine & Nutrition news Specialties

Divergent Impacts of Low- and High-Protein Fasting-Mimicking Diets on Cardiometabolic Health and Autophagy

By MedXY 08/30/2025

A 7-day randomized study shows that both low- and high-protein fasting-mimicking diets improve cardiometabolic health and autophagy, with high-protein variants uniquely enhancing visceral fat reduction, lipid profiles, heart rate variability, and gut microbiome diversity.

Family Medicine & Nutrition news Specialties

Exploring the Therapeutic Potential of Betaine and Its Derivatives in Cancer Treatment: From Mechanisms to Clinical Implications

By MedXY 08/30/2025

Betaine, a natural methyl donor with antioxidant and anti-inflammatory properties, demonstrates promising anticancer activity across multiple cancer types. Its derivatives and nanotechnology-assisted delivery systems enhance therapeutic efficacy and safety, offering innovative avenues for cancer management.

Clinical Updates Family Medicine & Nutrition news Specialties

Beetroot Juice and Physical Performance: Population-Specific Benefits and Optimal Supplementation Strategies

By MedXY 08/30/2025

Beetroot juice supplementation offers modest improvements in physical performance, enhancing muscular strength in professional athletes and aerobic endurance and lactate tolerance in healthy individuals. Acute dosing 2-3 hours pre-exercise with 8.3-16.4 mmol nitrate is optimal.

Family Medicine & Nutrition news Specialties

Enhancing Muscle Function in Older Adults: The Impact of Short-Term Dietary Nitrate Supplementation

By MedXY 08/30/2025

Short-term nitrate supplementation via beetroot juice improves muscle contractile properties and reduces fatigue in older adults, with no similar benefits observed in younger individuals.

Clinical Updates Family Medicine & Nutrition news OB/GYN & Women's Health Specialties

Enhancing Muscle Strength in Postmenopausal Women: Eight Weeks of Nitrate-Rich Beetroot Extract Supplementation Improves Muscle Function and Nitrate Bioavailability

By MedXY 08/30/2025

Eight weeks of nitrate-rich beetroot extract supplementation significantly increases fasting nitrate and nitrite levels, improving knee extensor muscle strength and power in postmenopausal women.

Clinical Updates Hematology-Oncology news Specialties

Novel Efficacy and Safety of Obinutuzumab Combined with Lenalidomide in First-Line Treatment of High Tumor Burden Follicular Lymphoma

By MedXY 08/30/2025

This phase 2 study demonstrates that obinutuzumab plus lenalidomide achieves high response rates with durable progression-free survival and manageable toxicities in untreated high tumor burden follicular lymphoma, suggesting a promising frontline option.

Medical News news

Statins: Beyond Heart Health—A New Weapon Against Cancer Prevention

By MedXY 08/30/2025

Recent research uncovers that long-term statin use may prevent certain inflammation-driven cancers by blocking IL-33, heralding new possibilities in cancer prevention strategies.