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Precision Genomics Outperforms Empirical Approaches in Managing Drug-Resistant Helicobacter pylori
Posted inGastroenterology Infectious Diseases news

Precision Genomics Outperforms Empirical Approaches in Managing Drug-Resistant Helicobacter pylori

Posted by MedXY By MedXY 12/29/2025
A global genomic study of Helicobacter pylori reveals that mutations in 23S rRNA and gyrA predict antibiotic resistance with 100% sensitivity, signaling the end of empirical therapy in favor of genotype-based personalized treatment.
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Whole‑Genome Sequencing Reveals HLA, FCGR2B and Complement C4 Copy‑Number as Distinct Genetic Drivers of IgG4‑Related Disease in Japan
Posted innews Rheumatology

Whole‑Genome Sequencing Reveals HLA, FCGR2B and Complement C4 Copy‑Number as Distinct Genetic Drivers of IgG4‑Related Disease in Japan

Posted by MedXY By MedXY 11/25/2025
A Japanese whole‑genome sequencing study identifies FCGR2B, specific HLA amino‑acid residues, and complement C4 copy‑number variation as independent genetic risk factors for IgG4‑related disease, with PTCH1 and a lncRNA linked to Mikulicz’s disease.
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Unlocking Prognostic and Therapeutic Insights in Breast Cancer Through Whole-Genome Sequencing Linked With Mortality Data
Posted innews Oncology

Unlocking Prognostic and Therapeutic Insights in Breast Cancer Through Whole-Genome Sequencing Linked With Mortality Data

Posted by MedXY By MedXY 10/15/2025
This retrospective UK study reveals that integrating whole-genome sequencing with clinical and mortality data enhances prognostication and identifies therapeutic targets in breast cancer, particularly in ER-positive, HER2-negative subtypes.
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  • Targeting the Right Brain: Structural Subtyping and Vascular Profiles Predict Response to Lifestyle Interventions in Dementia Prevention
  • Mediterranean Diet Outperforms Traditional Dietary Advice for Irritable Bowel Syndrome: A Landmark Randomized Trial
  • Six Months of Intermittent Fasting: Potent Lipid Lowering but Limited Impact on Vascular and Glycemic Markers
  • Interactive Mobile Coaching Improves Long-Term Quality of Life and Symptom Management After Gastrectomy
  • Preoperative Nutritional Support Significantly Reduces Postoperative Enterocolitis in Children with Hirschsprung Disease: A Multicenter Randomized Controlled Trial
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