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Disentangling Cognitive Decline: The Interplay of White Matter Hyperintensities and Cortical Metabolism in Amyloid-Negative Patients
Posted inClinical Updates Neurology news

Disentangling Cognitive Decline: The Interplay of White Matter Hyperintensities and Cortical Metabolism in Amyloid-Negative Patients

Posted by MedXY By MedXY 03/15/2026
This review synthesizes findings on how periventricular white matter hyperintensities (PWMHs) drive cognitive impairment in Aβ-negative individuals through distinct metabolic mediation and direct structural pathways, highlighting the clinical value of multi-modal PET/MRI imaging.
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Tau Links Amyloid and Vascular Burden to Faster Clinical Decline: Chronicity Reveals Synergy Between White Matter Injury and Amyloid in Dementia Progression
Posted inNeurology news

Tau Links Amyloid and Vascular Burden to Faster Clinical Decline: Chronicity Reveals Synergy Between White Matter Injury and Amyloid in Dementia Progression

Posted by MedXY By MedXY 11/05/2025
Longer years above amyloid and white matter hyperintensity positivity predict faster clinical decline. White matter vascular burden amplifies amyloid-related progression, and tau accumulation mediates this effect, highlighting targets and timing for intervention.
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