Moderate-quality evidence from 14 RCTs supports combined immersive and nonimmersive VR with mirror therapy to enhance upper extremity function and hand dexterity in stroke survivors, though clinical significance needs cautious interpretation.
The ESTREL trial demonstrates that levodopa added to standardized rehabilitation does not significantly improve motor recovery after acute stroke, challenging its adjunctive use for enhancing neuroplasticity in stroke rehabilitation.
The SEARCH trial investigated visual scanning training versus sham therapy in stroke survivors with homonymous hemianopia, finding no significant difference yet highlighting potential placebo and clinician-engagement effects, informing future rehabilitation approaches.
A randomized controlled trial demonstrates that combining high-intensity interval training with robot-assisted gait therapy significantly improves gait speed, balance, and lower limb function in patients with chronic stroke compared to treadmill therapy alone.
An 8-week cardiorespiratory exercise program initiated 2 months after ischemic stroke improved cognitive performance at 12 months, despite no significant preservation of hippocampal volume compared with control. The intervention was safe and feasible, offering promising avenues for poststroke cognitive care.
This study evaluates the lasting benefits of vagus nerve stimulation combined with rehabilitation for stroke patients suffering from upper extremity impairments.
A Canadian multisite trial demonstrated that the Walk 'n Watch structured exercise protocol significantly improves walking endurance in subacute stroke patients during inpatient rehabilitation without increasing serious adverse events.