stroke – Medxy AI

Bridging IV Alteplase Before EVT Modestly Raises Intracranial Hemorrhage Risk — But Net Clinical Impact Is Complex

By MedXY 12/11/2025

An IPD meta-analysis of six randomized trials (2313 patients) found IV alteplase before EVT modestly increased intracranial hemorrhage—particularly parenchymal hematoma—yet ICH risk must be balanced against IVT-associated improvements in reperfusion and potential clinical benefit.

Neurology news

IV Thrombolysis Outperformed Endovascular Thrombectomy for Basilar Artery Occlusion in a Multicenter Cohort: What Clinicians Should Know

By MedXY 12/07/2025

A 523‑patient multicenter cohort found intravenous thrombolysis alone was associated with better 3‑month functional outcomes and lower mortality than endovascular thrombectomy (± IVT) for acute basilar artery occlusion after adjustment for confounders. Results prompt cautious reappraisal of EVT vs IVT in BAO and call for randomized trials.

Neurology news

Giving IV Thrombolysis in the Late Window Before Transfer for Thrombectomy: Improved Recanalization and 3‑Month Outcomes in a Multicenter French Cohort

By MedXY 12/06/2025

A multicenter retrospective cohort (OPEN-WINDOW) found that IV thrombolysis given beyond 4.5 hours before interhospital transfer for EVT was associated with higher rates of recanalization during transfer and better 3‑month functional outcomes without increased hemorrhagic complications.

Cardiology Neurology news

Left Atrial Appendage Occlusion Reduces Cardioembolic Strokes and Improves Stroke Outcomes: Insights From LAAOS III Post Hoc Analysis

By MedXY 11/25/2025

Post hoc analyses of LAAOS III show surgical left atrial appendage occlusion (LAAO) during cardiac surgery lowers the proportion of cardioembolic and cortical infarcts and is associated with less disability and lower early mortality after ischemic stroke.

Neurology news Respiratory

Boosting Sleep Apnea Diagnosis After Stroke: A Quality Improvement Breakthrough

By MedXY 11/17/2025

A quality improvement program significantly increased obstructive sleep apnea testing in stroke and TIA patients, advancing guideline-based care in cerebrovascular health.

Neurology news

Reevaluating Intravenous Tenecteplase in Minor Disabling Stroke: Insights from the TEMPO-2 Secondary Analysis

By MedXY 10/29/2025

A secondary analysis of the TEMPO-2 trial shows that intravenous tenecteplase does not improve 90-day outcomes in minor disabling stroke defined by NIHSS scores, highlighting the need to reconsider thrombolysis in this patient population.

Neurology news Public Health

Age-Dependent Impact of Vascular Risk Factors on Acute Stroke: Insights from the INTERSTROKE Study

By MedXY 10/20/2025

The INTERSTROKE study reveals how age modifies the relationship between vascular risk factors and acute stroke, highlighting age-specific prevention priorities to reduce stroke burden globally.

Clinical Updates Neurology Specialties

Optimizing Head Positioning in Large Vessel Occlusion Stroke Before Thrombectomy: Evidence from a Randomized Clinical Trial

By MedXY 09/11/2025

A recent randomized clinical trial demonstrates that 0° head-of-bed positioning prior to thrombectomy in patients with large vessel occlusion stroke preserves neurological stability and reduces mortality compared to the conventional 30° elevation.

Clinical Updates Neurology news Specialties

Endovascular Therapy Shows Lasting Benefits Over Medical Management in Large Ischemic Stroke: 1-Year Results from the ANGEL-ASPECT Trial

By MedXY 08/26/2025

The ANGEL-ASPECT trial demonstrates that endovascular therapy (EVT) significantly improves 1-year functional outcomes compared to medical management in patients with large ischemic stroke, confirming durable disability reduction despite similar mortality rates.

Family Medicine & Nutrition Medical News Neurology news Specialties

Stroke Strikes Silently but Is 90% Preventable: Recognize the Warning Signs and Act Fast

By MedXY 08/23/2025

Stroke, a sudden interruption of brain blood flow, can lead to severe disability or death but is largely preventable. Early recognition and timely intervention can save lives and reduce complications.

Neurology news Specialties

Thrombolysis Before Thrombectomy May Raise ICH Risk After Stroke: A Comprehensive Review of Recent Evidence

By MedXY 08/19/2025

A meta-analysis of over 2000 stroke patients found that intravenous thrombolysis (IVT) before endovascular treatment (EVT) modestly increases intracranial hemorrhage (ICH) risk, especially in patients with elevated glucose and blood pressure, though functional benefits may still outweigh risks.

Neurology news Specialties

SUMMIT MAX Trial Validates Super Large Bore HiPoint System for Effective and Safe Aspiration Thrombectomy in Large Vessel Occlusion Stroke

By MedXY 08/17/2025

The SUMMIT MAX randomized trial demonstrates that the super large bore HiPoint reperfusion system is noninferior to the Vecta system in reperfusion success and safety for acute ischemic stroke due to large vessel occlusion.

Cardiology Clinical Updates Nephrology Neurology news Specialties

OPTIMAS Trial: Early vs. Delayed Anticoagulation in Acute Ischemic Stroke with Atrial Fibrillation and Chronic Kidney Disease

By MedXY 08/13/2025

The OPTIMAS trial shows that chronic kidney disease does not alter the safety or efficacy of early direct oral anticoagulant use after acute ischemic stroke with atrial fibrillation, supporting early initiation regardless of kidney status.

Diabetes & Endocrinology Neurology news Specialties

Diabetic Peripheral Neuropathy as a Predictor of Lacunar Stroke in Diabetes Patients

By MedXY 08/11/2025

A study reveals diabetic peripheral neuropathy (DPN) significantly associates with cerebral small-vessel disease (SVD), indicating a predictive role for lacunar stroke in diabetic patients and highlighting opportunities for early intervention.

Neurology news Specialties

Before the Stroke: How It Often Feels — Survivors’ Voices, What Science Explains, and What to Do

By MedXY 08/10/2025

Many strokes begin with strange, sudden sensations. Survivors describe fatigue, dizziness, confusion, sudden weakness and falls. Learn what these experiences mean, the science behind them, how to spot danger fast, and practical steps to reduce your risk.

Neurology news Specialties

Can High Pillows Trigger Stroke? Understanding the Causes of Brain Stroke

By MedXY 08/08/2025

This article explores how excessively high pillows may increase stroke risk by affecting neck blood vessels, discusses other stroke risk factors, and offers guidance on pillow choice and sleep positions for better health.

Cardiology news Specialties

5 Effective Prevention Exercises to teach you how to prevent the signs of cerebral infarction…

By MedXY 08/04/2025

Stroke affects millions annually, with early symptoms such as numbness in the tongue and limbs signaling urgent attention. This article explains stroke basics, warning signs, and five practical exercises to help prevent stroke.

Neurology Specialties

Tenecteplase in Modern Stroke Care: Comparative Insights from Recent Chinese Clinical Trials

By MedXY 08/01/2025

Three major Chinese trials examine intravenous and intra-arterial tenecteplase as adjuncts to thrombectomy in acute large-vessel occlusion stroke, revealing functional benefit with intravenous use before thrombectomy but not after reperfusion.

Clinical Updates Neurology news Specialties

Intra-arterial Tenecteplase After Thrombectomy for Acute Stroke: Interpreting the ANGEL-TNK Randomized Clinical Trial

By MedXY 07/31/2025

The ANGEL-TNK trial found that intra-arterial tenecteplase after successful endovascular thrombectomy improved excellent neurological outcomes at 90 days without increasing bleeding or mortality, but secondary outcomes showed no significant benefit.

Clinical Updates news

Intra-arterial Tenecteplase After Thrombectomy for Acute Stroke: Interpreting the ANGEL-TNK Randomized Clinical Trial

By MedXY 07/31/2025