sepsis – Medxy AI

Hemodynamic vs. Neurological Phenotypes in Adult Invasive Meningococcal Disease: Insights from the Nationwide RETRO-MENINGO Study

By MedXY 12/28/2025

The RETRO-MENINGO study of 654 adults reveals that hemodynamic presentations of invasive meningococcal disease carry a five-fold higher mortality risk than neurological forms. Early parenteral antibiotic administration remains the most critical modifiable factor for patient survival.

Critical Care Gastroenterology news

Tracking the Immune Pulse: Why mHLA-DR Trajectories Predict Survival in Sepsis and Liver Transplantation

By MedXY 12/27/2025

Large-scale cohort and prospective data reveal that monocyte HLA-DR expression is a dynamic predictor of ICU-acquired infections and mortality, offering a roadmap for personalized immunostimulant therapy in septic shock and transplant patients.

Critical Care Infectious Diseases news

Sepsis Survival in Australia and New Zealand: Analyzing Two Decades of Progress and the Recent Mortality Rebound

By MedXY 12/27/2025

A large-scale study of over 300,000 ANZ ICU patients reveals that sepsis mortality plummeted from 28% to 11% between 2000 and 2020, followed by a concerning 0.9% annual increase through 2023, highlighting both clinical triumphs and emerging challenges in critical care.

Critical Care Infectious Diseases news

Safe Stewardship: Antibiotic De-escalation by Day 4 Reduces Hospitalization Length Without Increasing Mortality in Community-Onset Sepsis

By MedXY 12/24/2025

A large-scale target trial emulation demonstrates that de-escalating anti-MRSA and anti-pseudomonal therapy on day 4 of sepsis treatment is safe, associated with fewer antibiotic days, and leads to shorter hospital stays compared to continuing broad-spectrum regimens.

Anesthesiology Critical Care Hematology-Oncology news

RBC Transfusions in Early Sepsis Resuscitation: Common, Complex, and Potentially Harmful Above a 10 g/dL Threshold

By MedXY 12/11/2025

In a multicenter Korean sepsis cohort, early RBC transfusions were frequent and driven by illness severity. No overall 60‑day mortality difference was seen after propensity matching, but transfusion was associated with harm at hemoglobin ≥10 g/dL and a possible benefit below that threshold.

Critical Care Infectious Diseases news

Precision Immunotherapy for Sepsis: ImmunoSep Trial Shows Early Organ‑Function Benefit with Targeted Anakinra or IFN‑γ

By MedXY 12/08/2025

The ImmunoSep randomized trial found that biomarker-guided immunotherapy (anakinra for macrophage activation‑like syndrome; interferon‑γ for sepsis‑induced immunoparalysis) improved organ dysfunction by day 9 versus placebo, though 28‑day mortality was unchanged. Safety signals require follow‑up.

Critical Care Infectious Diseases news Pediatrics

Epstein-Barr Virus and Pediatric Sepsis: Unraveling Links to Immune Dysregulation and Mortality

By MedXY 10/27/2025

This study links EBV seropositivity to immune dysregulation and increased mortality in pediatric sepsis, highlighting potential pathways for targeted therapies.

Critical Care Emergency Medicine news

Reassessing the Safety of Peripheral Vasopressor Use in Early Sepsis: Evidence from a Large Prospective Cohort Study

By MedXY 10/27/2025

This study evaluates factors influencing vasopressor route choice in sepsis and demonstrates low complication rates associated with peripheral administration, supporting its safety in early resuscitation.

Clinical Updates Critical Care news

Endothelial Glycocalyx Degradation in Sepsis: Insights from the CLOVERS Trial on Fluid Resuscitation Strategies and Mortality

By MedXY 09/19/2025

This article reviews findings from the CLOVERS trial analyzing endothelial glycocalyx degradation in sepsis, demonstrating its strong association with mortality but showing no impact of liberal versus restrictive fluid resuscitation strategies on glycocalyx integrity or survival outcomes.

Clinical Updates Critical Care news Specialties

Assessing the Impact of a Ketogenic Diet in Critically Ill Sepsis Patients: An Open-Label Randomized Controlled Trial

By MedXY 08/08/2025

This trial demonstrates that a ketogenic diet safely induces stable ketosis in sepsis patients, improving metabolic parameters and immune regulation without adverse effects, suggesting potential benefits for sepsis-related organ dysfunction.