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Clozapine Works Beyond Schizophrenia: Nationwide Evidence for Transdiagnostic Effectiveness and Safety
Posted innews Psychiatry

Clozapine Works Beyond Schizophrenia: Nationwide Evidence for Transdiagnostic Effectiveness and Safety

Posted by By MedXY 12/01/2025
Large Finnish and Swedish registry cohorts show clozapine is associated with lower psychiatric hospitalisation across schizophrenia-spectrum, bipolar disorder and severe depression without increased overall mortality or hospitalisation.
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Prior Osteotomy Lowers Implant Survival and Raises TKA Complexity — but Early Pain and Function Are Similar: Results from 189,932 Dutch Arthroplasties
Posted innews Orthopedics

Prior Osteotomy Lowers Implant Survival and Raises TKA Complexity — but Early Pain and Function Are Similar: Results from 189,932 Dutch Arthroplasties

Posted by By MedXY 11/02/2025
A large Dutch registry analysis shows total knee arthroplasty (TKA) after prior knee osteotomy carries a modestly higher revision risk and more frequent use of stems/augments, while short-term pain and function are comparable to primary TKA.
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  • History of Thrombosis and Hematologic Disease Double the Risk of New Clots in Persistently aPL‑Positive Patients: Prospective APS ACTION Registry Analysis
  • Can an 11β‑HSD1 Inhibitor Improve Prednisolone’s Benefit–Risk Ratio in Polymyalgia Rheumatica? Early Human Trial Suggests Feasibility
  • Tirzepatide Lowers 10‑Year Predicted Risk of Cardiovascular Disease and Type 2 Diabetes in Adults with Obesity and Prediabetes: Post hoc Analysis of SURMOUNT‑1
  • Artificial Intelligence-Enabled Prediction of Heart Failure Risk From Single-Lead Electrocardiograms: A Multinational Cohort Review
  • ED-Delivered Education Plus mHealth Lowers Systolic BP — TOUCHED Trial Shows a Modest but Meaningful 4.9 mm Hg Reduction at 6 Months
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