randomized trial 2

Cerebral Embolic Protection Fails to Preserve Cognitive Function After TAVI: Insights from the BHF PROTECT-TAVI Trial

By MedXY 09/06/2025

The BHF PROTECT-TAVI randomized trial reveals that cerebral embolic protection (CEP) devices do not prevent cognitive decline following transcatheter aortic valve implantation (TAVI), challenging assumptions about their neuroprotective benefits.

Family Medicine & Nutrition Orthopedics Specialties

Comparative Effectiveness of Cupping and Scraping Therapy Versus NSAIDs for Chronic Nonspecific Low-Back Pain: Insights from a Multicenter Randomized Trial

By MedXY 08/26/2025

A recent multicenter randomized trial demonstrates superior short-term efficacy of cupping and scraping therapy with medicated balm over NSAIDs with capsaicin plasters in reducing pain and improving quality of life for chronic nonspecific low-back pain.

Dentistry Family Medicine & Nutrition news Plastic Surgery Specialties

Can Kissing Save Your Smile? Exploring Its Potential Protective Role Against Dental Cavities

By MedXY 08/26/2025

New research explores whether kissing can help restore saliva's pH balance after sugary drinks, potentially protecting against dental caries.

Cardiology Clinical Updates Neurology news Specialties

Evaluating Thigh-High Compression Stockings in Preventing Vasovagal Syncope Recurrence: Insights from a Randomized Sham-Controlled Trial

By MedXY 08/17/2025

A randomized sham-controlled trial found that thigh-high elastic compression stockings did not significantly reduce vasovagal syncope recurrence or improve syncope-free survival, though fewer episodes occurred during active stocking use.

AI Clinical Updates Nephrology news Specialties

Evaluating Electronic Nudges to Enhance Guideline-Directed Therapy in Chronic Kidney Disease: Insights from the NUDGE-CKD Trial

By MedXY 08/16/2025

The NUDGE-CKD trial found that electronic letter-based nudges to patients with chronic kidney disease and their general practitioners did not significantly improve initiation of guideline-recommended medications over usual care.

Gastroenterology General Surgery news Specialties

Appendicectomy Plus Medical Therapy Significantly Reduces Relapse in Ulcerative Colitis: Insights from the ACCURE Trial

By MedXY 08/14/2025

The ACCURE trial demonstrates that laparoscopic appendicectomy combined with standard medical therapy significantly lowers 1-year relapse rates compared to medical therapy alone in ulcerative colitis patients in remission.

Clinical Updates Gastroenterology news Psychiatry Specialties

Therapist-Guided Internet CBT Cuts Bulimia Episodes: A Japanese Randomized Trial with Promising Clinical Implications

By MedXY 08/09/2025

A multicenter randomized trial in Japan found that a 12-week therapist-guided internet-based CBT program significantly reduced weekly bingeing and compensatory episodes in women with bulimia nervosa versus usual care (adjusted mean difference 9.84 episodes; Cohen d 0.73).

Critical Care news Specialties

UK-ROX Trial: Conservative Oxygen Strategy in Mechanically Ventilated ICU Patients — No 90‑Day Survival Benefit

By MedXY 08/09/2025

The UK-ROX randomized trial (n=16,500) found that targeting SpO2 90% (88–92%) to reduce oxygen exposure did not reduce 90‑day all‑cause mortality versus usual care in mechanically ventilated adults.

Clinical Updates Family Medicine & Nutrition Neurology news Pediatrics Specialties

Ketogenic Diet vs Further Antiseizure Medication in Infants with Drug-Resistant Epilepsy: What the KIWE Trial Adds to Clinical Practice

By MedXY 08/09/2025

The KIWE randomised trial (Lancet Neurol 2023) found no superiority of a classic ketogenic diet over an additional antiseizure medication for seizure frequency in infants (1–24 months) with drug‑resistant epilepsy; tolerability and safety profiles were similar, supporting the diet as a viable treatment option.

Clinical Updates news Orthopedics Specialties

Exercise Alone Matches Diet Plus Exercise for Hip Osteoarthritis Pain Relief, Large Randomized Trial Shows

By MedXY 08/04/2025

Adding a very-low-calorie diet to exercise yields no additional pain relief for overweight or obese adults with hip osteoarthritis, despite greater weight loss.

Clinical Updates Infectious Diseases news Specialties Urology

Individualised Versus Standard 10-Day Antibiotic Therapy in Pediatric Febrile UTI: Insights from the INDI-UTI Trial

By MedXY 08/02/2025

A Danish multicentre trial found individualised, shorter antibiotic regimens for febrile pediatric UTIs reduce overall antibiotic exposure and adverse events, but with a modestly higher recurrence risk compared to standard 10-day treatment.

Cardiology Clinical Updates news Specialties

Routine Use of Cerebral Embolic Protection in TAVI: Evidence, Outcomes, and Clinical Implications

By MedXY 08/01/2025

Large-scale trials show that routine cerebral embolic protection during TAVI does not significantly reduce early stroke rates, though selective benefits in major stroke and secondary outcomes may exist.

Cardiology Clinical Updates news Specialties

Acute Normovolemic Hemodilution in Cardiac Surgery: No Reduction in Allogeneic Transfusion—Insights from a Multinational Randomized Trial

By MedXY 07/31/2025

A large multinational trial found that acute normovolemic hemodilution (ANH) did not significantly reduce allogeneic red-cell transfusion in adult cardiac surgery patients, with similar safety outcomes compared to usual care.

Clinical Updates Medical News Orthopedics Specialties

Medial Opening Wedge High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis: Evidence from a Randomized Controlled Trial

By MedXY 07/31/2025

A randomized trial demonstrates that medial opening wedge high tibial osteotomy (HTO) slows cartilage loss and improves symptoms in patients with medial compartment knee osteoarthritis and varus alignment, supporting its role as a joint-preserving intervention.

Clinical Updates Family Medicine & Nutrition news Specialties

Structured vs Self-Guided Multidomain Lifestyle Interventions for Cognitive Health: Insights from the US POINTER Randomized Clinical Trial

By MedXY 07/30/2025

A large US trial found that structured, intensive lifestyle interventions led to greater improvements in global cognition over two years compared to self-guided approaches among older adults at risk for cognitive decline.