randomized controlled trial

Enhanced Exercise Rehabilitation via Tailored Adherence Support Improves Outcomes in Vertebral Fragility Fractures: Insights from the OPTIN Randomised Controlled Trial

By MedXY 10/24/2025

Integrating tailored adherence support into exercise rehabilitation for vertebral fragility fractures significantly improves functional mobility and walking capacity compared to standard exercise alone at 12 months.

Family Medicine & Nutrition Neurology Nursing & care Specialties

Evaluating Combined Mind-Body Exercise, Cognitive Training, and Nurse-Led Risk Factor Modification in Mild Cognitive Impairment: Insights from a Three-Arm Randomized Controlled Trial

By MedXY 10/20/2025

A large RCT in primary care showed no significant cognitive benefits of a combined intervention integrating mind-body physical exercise, cognitive training, and nurse-led risk factor modification over nurse-led risk factor modification alone or general health advice in mild cognitive impairment. Future refinements and research are needed.

Neurology news Public Health

Iyengar Yoga and Fall Risk in Older Adults: Unexpected Outcomes from a Rigorous RCT

By MedXY 10/20/2025

A large randomized controlled trial found that an Iyengar yoga-based exercise program increased fall rates among older adults compared to seated relaxation yoga, despite improvements in physical activity and balance confidence, highlighting the need for modified fall prevention yoga programs.

OB/GYN & Women's Health Psychiatry Specialties

Evaluating the Effectiveness of Circle of Security-Parenting for Perinatal Mental Health: Insights from a Large-Scale RCT

By MedXY 10/18/2025

This study finds no significant benefit of the Circle of Security-Parenting intervention added to usual care for improving mental health and bonding among new parents in NHS settings.

General Surgery Neurology news

Efficacy and Safety of Shunt Surgery in Idiopathic Normal-Pressure Hydrocephalus: Insights from a Rigorous Randomized Controlled Trial

By MedXY 09/27/2025

A double-blind, placebo-controlled trial demonstrates that shunt surgery significantly improves gait velocity and balance in patients with idiopathic normal-pressure hydrocephalus who respond to temporary CSF drainage, with mixed safety outcomes and no cognitive or urinary symptom benefits at 3 months.

Clinical Updates Neurology news Ophthalmology

Evaluating Visual Scanning Training for Post-Stroke Homonymous Hemianopia: Insights from the SEARCH Trial

By MedXY 09/22/2025

The SEARCH trial investigated visual scanning training versus sham therapy in stroke survivors with homonymous hemianopia, finding no significant difference yet highlighting potential placebo and clinician-engagement effects, informing future rehabilitation approaches.

Clinical Updates HIV/AIDS news Respiratory

Adjunctive Corticosteroids in Severe Pneumocystis jirovecii Pneumonia Among HIV-negative Patients: Insights from a Multicentre Randomised Trial

By MedXY 09/21/2025

A multicentre randomized trial evaluated adjunctive corticosteroids in HIV-negative severe Pneumocystis jirovecii pneumonia, showing a non-significant reduction in 28-day mortality and no safety concerns, and calls for further targeted research.

Clinical Updates Family Medicine & Nutrition news OB/GYN & Women's Health Specialties

Vitamin D3 as a Potential Therapeutic Agent in Polycystic Ovary Syndrome: Insights from a Prospective Double-Blind Randomized Trial

By MedXY 09/16/2025

A recent double-blind randomized controlled trial demonstrates that weekly supplementation with vitamin D3 significantly improves ovarian morphology, menstrual regularity, and ovulation rates in women with PCOS, suggesting a role as standalone or adjunctive therapy.

AI Cardiology news Specialties

Harnessing AI: LLM-Based Conversational Agents Reduce Depression and Anxiety Among Young Adults in Short Video App Trial

By MedXY 09/14/2025

A 28-day RCT demonstrates that a conversational AI trained on a large language model effectively reduces mild depression and anxiety symptoms in young adults through dialog interventions integrated in short video apps.

Diabetes & Endocrinology news Specialties

Automated Insulin Delivery in Insulin-Treated Type 2 Diabetes: A Comprehensive Review of Randomized Controlled Trial Evidence and Clinical Implications

By MedXY 09/10/2025

Automated insulin delivery (AID) significantly improves glycemic control in insulin-treated type 2 diabetes, demonstrating greater HbA1c reduction and increased time in target glucose range compared to traditional insulin delivery methods.

AI Clinical Updates news Psychiatry Specialties

Evaluating a Proactive E-Health Intervention for Co-occurring At-Risk Alcohol Use and Depressive Symptoms: Adherence, Reach, and Two-Year Outcomes

By MedXY 08/25/2025

This RCT assessed a proactive e-health intervention for patients with at-risk alcohol use and depressive symptoms, showing high adherence but only small, non-significant improvements at 12 months and no lasting effects at 24 months.

Clinical Updates Specialties

Safety and Efficacy of Rotigotine in Frontotemporal Dementia: Insights from a Phase 2 Double-Blind Multicenter Trial

By MedXY 08/22/2025

This phase 2 trial found no significant cognitive or behavioral benefits of rotigotine in bvFTD patients over 24 weeks, highlighting the challenges in dopaminergic therapy for frontotemporal dementia.

Cardiology Specialties

Clinical Outcomes of Conduction System Pacing vs Right Ventricular Septal Pacing in Atrioventricular Block: Insights from the CSPACE Randomized Controlled Trial

By MedXY 08/22/2025

This review synthesizes evidence from the CSPACE RCT demonstrating superior clinical outcomes of conduction system pacing over right ventricular septal pacing in AV block patients, emphasizing reduced pacing-induced cardiomyopathy and CRT upgrade rates.

AI news OB/GYN & Women's Health Specialties

Evaluating Digital Therapeutics for Midlife Women’s Menopausal Symptoms: A Synthesis of Recent Randomized Controlled Trials

By MedXY 08/20/2025

This review synthesizes evidence on mobile digital therapeutics targeting vasomotor and behavioral health symptoms in menopausal and midlife women, highlighting efficacy, engagement, and implications for scalable symptom management.

AI news Psychiatry Specialties

Efficacy and Safety of ALM-003 Digital Therapeutic in Alcohol Dependence: A Multicenter Open-Label Randomized Controlled Trial

By MedXY 08/20/2025

This review synthesizes evidence from a multicenter RCT showing ALM-003 digital therapeutic reduces heavy drinking days significantly in alcohol-dependent individuals at high risk, with an excellent safety profile.

Cardiology news Specialties

Thoracentesis in Acute Heart Failure: Insights from the TAP-IT Randomized Controlled Trial

By MedXY 08/17/2025

The TAP-IT trial found that additional thoracentesis in acute heart failure patients with pleural effusion did not improve days alive out of hospital, mortality, or length of stay compared to standard therapy alone.

Family Medicine & Nutrition Gastroenterology news Specialties

Examining the Role of Gluten and Wheat in Irritable Bowel Syndrome: Insights from a Double-Blind, Sham-Controlled Crossover Trial

By MedXY 08/14/2025

A rigorous trial reveals that perceived symptom worsening from gluten or wheat in IBS patients may largely be driven by expectation rather than the substances themselves, underscoring the importance of distinguishing true sensitivities from placebo effects.

Critical Care news Specialties

Iloprost in Severe Septic Shock with Persistent Hypoperfusion: Insights from a Rigorous Randomized Trial

By MedXY 08/13/2025

A recent double-blind RCT shows iloprost did not reduce organ failure severity in septic shock patients with persistent hypoperfusion, highlighting challenges in improving outcomes despite theoretical benefits in microcirculation.

Cardiology Family Medicine & Nutrition news Specialties

Mediterranean Diet vs. Australian Guide to Healthy Eating: A Comparison on Body Composition and Glucose Metabolism

By MedXY 08/11/2025

This study compares the effects of the Mediterranean diet and the Australian Guide to Healthy Eating (AGHE) on body composition and glucose metabolism, revealing significant benefits of the Mediterranean diet.

Clinical Updates Diabetes & Endocrinology Family Medicine & Nutrition news Specialties

Three Weeks of Ketogenic Diet Significantly Boosts Skeletal Muscle Insulin Sensitivity in Obesity: Insights from a Randomized Crossover Trial

By MedXY 08/08/2025

A 3-week ketogenic diet improved skeletal muscle insulin sensitivity and promoted weight loss in individuals with obesity, without significant effects on liver or adipose tissue insulin sensitivity.