Pharmacokinetics – Medxy AI

Optimizing Pyrazinamide Dosing in Drug-Susceptible Pulmonary Tuberculosis: Insights from a Large Phase 3 Trial

By MedXY 09/17/2025

A comprehensive analysis from the TBTC Study 31/ACTG A5349 reveals that flat dosing of pyrazinamide at 1,000 mg daily optimizes efficacy and safety, challenging current weight-banded dosing strategies for drug-susceptible tuberculosis.

Clinical Updates Diabetes & Endocrinology news Specialties

Amycretin: A Promising First-in-Class Dual GLP-1 and Amylin Receptor Agonist for Overweight and Obesity

By MedXY 09/17/2025

Amycretin, a novel dual GLP-1 and amylin receptor agonist, demonstrated safety, tolerability, and dose-proportional pharmacokinetics in adults with overweight or obesity, supporting further trials on its weight loss efficacy.

Clinical Updates Family Medicine & Nutrition Internal Medicine news Specialties

Dihydroberberine: Enhanced Absorption and Emerging Therapeutic Potential Based on Recent Clinical and Mechanistic Insights

By MedXY 08/24/2025

Dihydroberberine demonstrates superior absorption compared to berberine, suggesting enhanced pharmacological properties. Recent studies highlight its potential in metabolic and inflammatory diseases, warranting further clinical exploration.

Clinical Updates Diabetes & Endocrinology news Specialties

Recent Advances in Dihydroberberine Research: Pharmacokinetics, Mechanisms, and Clinical Potential

By MedXY 08/24/2025

This review synthesizes the latest 5-year evidence on dihydroberberine, highlighting improved bioavailability over berberine, mechanistic insights from metabolic and network pharmacology studies, and its promising clinical applications in metabolic and respiratory diseases.

Clinical Updates news Psychiatry Specialties

Long-Acting Oral Weekly Risperidone (LYN-005): Translating Pharmacokinetic Equivalence to Clinical Opportunity in Schizophrenia

By MedXY 08/03/2025

Weekly LYN-005 demonstrated pharmacokinetic equivalence to daily risperidone, sustained therapeutic levels, and manageable safety in clinically stable patients, offering a novel option to address non-adherence in schizophrenia.

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Why Do Some Medicines Require a ‘Loading Dose’? The Science Behind the First Double Dose

By MedXY 07/27/2025

Exploring why certain medications start with a larger first dose, the clinical evidence, common misconceptions, and practical guidelines for safe use.