pharmacoepidemiology

Levothyroxine in the Ageing Patient: Re-evaluating Cardiovascular Outcomes in Subclinical Hypothyroidism through the ACEL-UK-ETT Trial

By MedXY 03/20/2026

This review analyzes the ACEL-UK-ETT emulated target trial, demonstrating that long-term levothyroxine therapy in older adults with subclinical hypothyroidism significantly reduces cardiovascular events and all-cause mortality without compromising bone health, provided age-specific TSH thresholds are utilized.

Internal Medicine news

Oral Corticosteroids During Pregnancy: A Nationwide Study Reassures on Gestational Diabetes Risk

By MedXY 01/01/2026

A large-scale Korean cohort study involving 1.3 million pregnancies found no overall association between oral corticosteroid use and gestational diabetes risk, supporting their clinical use when indicated, despite a minor risk increase observed in the very early first trimester.

Dermatology Diabetes & Endocrinology news

SGLT2 Inhibitors Associated with Lower Risk of New-Onset Atopic Dermatitis in People with Type 2 Diabetes: Nationwide Active-Comparator Cohort Study

By MedXY 11/01/2025

A Taiwanese nationwide cohort study found SGLT2 inhibitor use linked to a lower incidence of new-onset atopic dermatitis versus DPP4 inhibitors (IPTW-adjusted HR 0.847), with a dose-response effect and stronger protection in men.