Total Neoadjuvant Therapy Enables Organ Preservation Without Compromising Distant Control in pMMR/MSS Stage II–III Rectal Cancer: Insights from the NO-CUT Trial
Posted inGastroenterology news Oncology

Total Neoadjuvant Therapy Enables Organ Preservation Without Compromising Distant Control in pMMR/MSS Stage II–III Rectal Cancer: Insights from the NO-CUT Trial

The NO-CUT phase 2 trial shows that total neoadjuvant therapy (CAPOX-based TNT) followed by non-operative management for clinical complete responders achieved high 30‑month distant relapse‑free survival (95%) and enabled organ preservation in 26% of patients with pMMR/MSS stage II–III rectal cancer.
Two-thirds of ACL-injured Patients Avoid Surgery at 2 Years: Nationwide Registry Shows Rehab-first Strategy Often Works but Younger, Pivoting-sport Athletes and Meniscal Tears Predict Delayed Reconstruction
Posted innews Orthopedics Rehabilitation Medicine

Two-thirds of ACL-injured Patients Avoid Surgery at 2 Years: Nationwide Registry Shows Rehab-first Strategy Often Works but Younger, Pivoting-sport Athletes and Meniscal Tears Predict Delayed Reconstruction

A Norwegian registry study reports that 63% of patients with primary ACL injury initially managed non‑operatively remained non‑operative at two years; younger age, participation in pivoting sports and baseline meniscal injury increased risk of delayed ACL reconstruction, while 2‑year KOOS scores were similar.