Neuroimaging – Medxy AI

Targeting the Right Brain: Structural Subtyping and Vascular Profiles Predict Response to Lifestyle Interventions in Dementia Prevention

By MedXY 01/20/2026

A sub-analysis of the FINGER trial reveals that individuals with specific grey matter patterns and lower vascular risk derive the most structural brain benefit from multimodal lifestyle interventions, highlighting the potential for personalized dementia prevention strategies.

Neurology news Radiology

Midlife Plasma GFAP as a Long-Term Sentinel for Cerebral Small Vessel Disease: A Decadal Prospective Study

By MedXY 01/06/2026

Elevated plasma glial fibrillary acidic protein (GFAP) in middle age independently predicts the progression of cerebral small vessel disease MRI markers nearly a decade later, suggesting its potential as an early-stage prognostic biomarker for neurovascular decline.

Neurology news Radiology

Refining Risk Stratification: The IsCHEMiA Score Outperforms Existing Models in Predicting Poststroke Epilepsy

By MedXY 01/06/2026

The IsCHEMiA score, an imaging-based risk model validated across international cohorts, offers superior prediction of poststroke epilepsy compared to previous tools. By integrating clinical and neuroimaging markers, it provides a precise framework for personalized management and the design of future antiepileptogenic clinical trials.

Neurology news Public Health

Beyond the Lungs: How Ambient Air Pollution Drives Alzheimer’s Neuropathology and Cognitive Decline

By MedXY 01/02/2026

Emerging evidence confirms that air pollution, particularly PM2.5 and NO2, is directly associated with Alzheimer’s neuropathology, structural brain changes, and cognitive decline. New research highlights that these effects are partially mediated by pulmonary function and manifest as increased amyloid-related pathology at autopsy.

AI news Otorhinolaryngology

Deep Transfer Learning and Preimplant MRI: A Paradigm Shift in Predicting Pediatric Cochlear Implant Outcomes

By MedXY 12/29/2025

A multicenter study demonstrates that deep transfer learning (DTL) algorithms using preimplant MRI can predict spoken language development in children with cochlear implants with over 92% accuracy, significantly outperforming traditional machine learning models and clinical variables.

news Psychiatry Radiology

Mapping the Neuro-Immune Divide: Distinct Brain-Blood Signatures Distinguish Early Depression from Psychosis

By MedXY 12/24/2025

A large-scale multicenter study identifies unique multivariate patterns of peripheral inflammation and brain structure that differentiate early-stage depression and psychosis, highlighting the influence of childhood trauma and cognitive performance on these distinct neurobiological signatures.

Neurology news Psychiatry

Elevated Serotonin Release in Schizophrenia: New Insights Into Negative Symptom Pathophysiology

By MedXY 12/17/2025

A PET imaging study reveals increased frontal serotonin release in schizophrenia, particularly in deficit type, tied to worse negative symptoms.

Neurology Specialties

Oral Valiltramiprosate in APOEε4/ε4 Carriers with Early Alzheimer’s Disease: Insights from the Phase III APOLLOE4 Trial

By MedXY 10/21/2025

This phase III trial evaluated oral valiltramiprosate in APOEε4/ε4 homozygotes with early Alzheimer's, showing brain atrophy slowing but limited overall clinical benefit, with nominal improvements in mild cognitive impairment subgroups.

Neurology news Pathology & Lab Medicine Psychiatry Specialties

Amygdala Tau Pathology as a Key Contributor to Depressive Symptoms in Aging: Insights from Neuroimaging Studies

By MedXY 10/21/2025

Amygdala tau accumulation in cognitively normal older adults correlates with worsening depressive symptoms, especially in APOE ε4 carriers, highlighting its role in neuropsychiatric changes during aging.

Family Medicine & Nutrition Neurology news Specialties

APOE ε4 Allele: A Key Driver of Cognitive Decline and Neurodegeneration in Older Adults from the Democratic Republic of the Congo

By MedXY 10/21/2025

This study reveals that the APOE ε4 allele is linked to increased dementia prevalence, cognitive deficits, brain atrophy, and plasma biomarkers of neurodegeneration in older adults in the DRC, emphasizing its critical role in African populations.

Family Medicine & Nutrition Neurology news Specialties

Lifetime Walking Intensity and Duration Reduce Amyloid-β Accumulation in Alzheimer’s Disease: Insights from a Korean Longitudinal Cohort

By MedXY 10/20/2025

A 4-year longitudinal study reveals that long-duration, high-intensity lifetime walking is associated with reduced amyloid-β accumulation in older adults, suggesting a neuroprotective effect when initiated early in life.

Emergency Medicine Pediatrics Psychiatry Radiology

Delays in Pediatric Cannabis Toxicology Testing Lead to Increased Neuroimaging in Emergency Departments

By MedXY 10/09/2025

Delayed cannabis test results in children under 6 with poisoning symptoms prolong ED visits and influence neuroimaging use. Faster toxicology screening could optimize care and reduce unnecessary scans.

Neurology news Specialties

Sex-Specific Brain Volume Loss After Traumatic Brain Injury: Greater Impact in Older Women

By MedXY 07/31/2025

A study from the Framingham Heart Study cohort reveals that traumatic brain injury (TBI) is linked to significant brain volume loss in older women but not men, highlighting sex-specific vulnerability to neurodegeneration post-TBI.