neurocritical care

Perihematomal Edema Dynamics and Functional Outcomes in Spontaneous Intracerebral Hemorrhage: Insights from a Global IPD Meta-Analysis

By MedXY 03/10/2026

This article synthesizes evidence from a large-scale individual participant data meta-analysis, demonstrating that early perihematomal edema growth (at 24 and 72 hours) is an independent predictor of death and disability after intracerebral hemorrhage.

Critical Care news Pediatrics

Plasma GFAP and NfL as Real-Time Predictors of Brain Injury and Long-Term Disability in Pediatric ECMO

By MedXY 03/02/2026

A prospective study demonstrates that rising levels of plasma GFAP and NfL precede neuroimaging-confirmed brain injury in children on ECMO. These biomarkers are also strongly associated with mortality and long-term functional impairment, offering a new window for neuroprotective monitoring.

Emergency Medicine Neurology news

Recombinant Factor VIIa Fails to Improve Functional Outcomes in Hyperacute Intracerebral Haemorrhage Despite Reduced Bleeding: Results from the FASTEST Trial

By MedXY 02/17/2026

The FASTEST trial demonstrated that while recombinant factor VIIa administered within two hours of intracerebral haemorrhage onset significantly reduced hematoma growth, it failed to improve functional outcomes at 180 days and increased the risk of life-threatening thromboembolic events.

Critical Care Neurology news

Paracetamol Lowers Cerebral Temperature in Febrile Brain‑Injured Patients — NEUROTHERM RCT Shows a Modest, Clinically Relevant Effect

By MedXY 12/10/2025

In the NEUROTHERM randomized pharmacodynamic trial, a single IV dose of paracetamol reduced intracerebral temperature by a mean 0.6°C in febrile brain‑injured patients and kept temperatures <38.5°C for a median 3.6 hours versus virtually none with placebo.

Anesthesiology Critical Care Hematology-Oncology news

Restrictive Red Blood Cell Transfusion Is Safe for Most Patients — Except in Neurocritical Care (and Some Bleeding Syndromes)

By MedXY 11/06/2025

A Cochrane update (2025) of 69 randomized trials found restrictive RBC transfusion thresholds (typically Hb 7–8 g/dL) cut transfusion exposure ~42% without increasing 30‑day mortality overall, but liberal strategies improved long‑term neurological outcomes after brain injury and restrictive thresholds reduced mortality in GI bleeding.