metabolic syndrome

Metformin Did Not Prevent Metabolic Syndrome During ADT but Improved Weight, Waist and HbA1c: Findings from the PRIME Phase 3 Trial

By MedXY 11/17/2025

In the PRIME randomized phase 3 trial, metformin did not significantly reduce metabolic syndrome incidence in men starting androgen deprivation therapy, but produced modest, clinically relevant reductions in body weight, waist circumference, and hemoglobin A1c.

Diabetes & Endocrinology Internal Medicine Specialties

Monlunabant Shows Promise for Weight Loss in Obesity and Metabolic Syndrome: A Phase 2A Trial Review

By MedXY 10/18/2025

This phase 2a trial demonstrates that monlunabant induces significant weight loss across various doses in obese adults with metabolic syndrome, with dose-dependent adverse events highlighting the need for further safety evaluation.

Clinical Updates Gastroenterology Internal Medicine news Specialties

HEC88473 Dual GLP-1/FGF21 Agonist: Advancing Treatment for MASLD and T2DM with Promising Safety and Efficacy

By MedXY 09/20/2025

A phase Ib/IIa trial demonstrated that HEC88473, a novel GLP-1/FGF21 dual agonist, is generally safe, effectively reduces liver fat, and improves glycemic and lipid profiles in MASLD patients with type 2 diabetes within five weeks of treatment.

Family Medicine & Nutrition news Specialties

Impact of Mediterranean Diet and Physical Activity on Bone Health in Older Adults: Insights from the PREDIMED-Plus Trial

By MedXY 09/18/2025

A 3-year randomized trial reveals that a weight-loss Mediterranean diet combined with physical activity helps prevent bone mineral density decline in older women with metabolic syndrome.

Diabetes & Endocrinology news OB/GYN & Women's Health Specialties

Enhanced Therapeutic Benefits of Combined Metformin and Curcumin in Women with Polycystic Ovary Syndrome: Results from a Factorial Clinical Trial

By MedXY 09/16/2025

A 12-week randomized trial demonstrates that combining metformin and nanocurcumin significantly improves lipid metabolism, glucose regulation, hormonal balance, and body metrics in women with PCOS, surpassing effects seen with either agent alone or placebo.

Diabetes & Endocrinology Family Medicine & Nutrition Specialties

Metformin with or without Mediterranean Diet Significantly Reduces Diabetes Risk in Metabolic Syndrome: Insights from the MeMeMe Trial

By MedXY 09/16/2025

The MeMeMe randomized trial shows that metformin 1,700 mg/day effectively prevents type 2 diabetes in metabolic syndrome patients, independent of Mediterranean diet adherence, with implications for age-related disease prevention.

Diabetes & Endocrinology Neurology news Specialties

Metabolic Syndrome Increases Parkinson’s Disease Risk: Implications for Clinical Practice and Prevention

By MedXY 08/30/2025

A large cohort study reveals that metabolic syndrome significantly raises Parkinson’s disease risk by 39%, with even greater risk in genetically predisposed individuals, highlighting the importance of metabolic health management in PD prevention.

Cardiology Diabetes & Endocrinology Nephrology Specialties

Flexovital Food Supplement Shows Promise in Mitigating Cardiovascular-Kidney-Metabolic Syndrome in Preclinical Model

By MedXY 08/30/2025

Flexovital, a nitric oxide-enhancing supplement, effectively attenuates metabolic, cardiovascular, and renal dysfunctions in a mouse model of cardiovascular-kidney-metabolic syndrome induced by unilateral nephrectomy and Western diet.

Diabetes & Endocrinology Neurology news Specialties

Metabolic Syndrome: The Hidden Highway to Dementia in Older Adults

By MedXY 08/26/2025

Metabolic syndrome—characterized by five key metabolic risk factors—significantly increases the risk of dementia, especially vascular dementia, among older adults. Early detection and lifestyle interventions are crucial to protect brain health.

Cardiology Clinical Updates Diabetes & Endocrinology Family Medicine & Nutrition Neurology news Specialties

Recent Advances in Cinnamon and Its Extracts: Clinical Applications and Therapeutic Potentials Across Metabolic, Cardiovascular, Cognitive, and Infectious Diseases

By MedXY 08/24/2025

A decade of research highlights cinnamon's benefits in glycemic control, lipid modulation, anti-inflammatory effects, cognitive enhancement, and antimicrobial activity, supporting its adjunctive clinical use and revealing promising therapeutic directions.

Cardiology Diabetes & Endocrinology Family Medicine & Nutrition Neurology Specialties

Protective Effects of High-Intensity Interval Training on Cardiovascular, Neurological, and Metabolic Health: An Evidence-Based Review

By MedXY 08/18/2025

This review synthesizes recent evidence demonstrating that high-intensity interval training (HIIT) confers cardiometabolic benefits, modulates microvascular and neural function, enhances insulin sensitivity, and improves mental health outcomes, underscoring its potential as a multifaceted therapeutic strategy.

Diabetes & Endocrinology Family Medicine & Nutrition Gastroenterology news Specialties

Flaxseed Powder Supplementation: Emerging Evidence in Non-Alcoholic Fatty Liver Disease and Metabolic Health

By MedXY 08/08/2025

Flaxseed powder supplementation shows promise in improving liver fat, lipid metabolism, and inflammation in NAFLD and related metabolic disorders, with effects on gut microbiota but limited synergism with fasting mimicking diets.

Gastroenterology Medical News news Specialties

Sharp Rise in Advanced Alcohol-Related Liver Disease Despite Stable Drinking Rates: Changing Population Risks Highlighted by US Data

By MedXY 07/31/2025

A twofold rise in advanced liver fibrosis among US heavy drinkers over two decades is linked to increased metabolic syndrome, age, and socioeconomic risk, not higher alcohol intake.

Clinical Updates news Pediatrics Specialties

Muscle Strength as a Key Determinant of Metabolic Risk in Paediatric Obesity: New Evidence from Milan

By MedXY 07/30/2025

Stronger leg muscles are linked to significantly lower risk of metabolic syndrome in children and adolescents with obesity, highlighting the importance of muscular fitness in paediatric metabolic health.