meta-analysis – Medxy AI

Lowering Blood Pressure in Isolated Diastolic Hypertension: Evidence Supports Risk Reduction Across All Diastolic Levels

By MedXY 01/05/2026

A large-scale meta-analysis reveals that lowering blood pressure in patients with isolated diastolic hypertension (IDH) provides cardiovascular protection comparable to those with systolic elevations, suggesting that diastolic thresholds alone should not preclude treatment in high-risk individuals.

Critical Care Internal Medicine news

Melatonin Does Not Prevent Delirium in the Intensive Care Unit: Insights from a Comprehensive Meta-Analysis

By MedXY 12/28/2025

A recent systematic review and meta-analysis of 13 randomized controlled trials concludes that melatonin fails to reduce the incidence of delirium or mortality in critically ill patients, challenging the routine use of this supplement in the intensive care setting.

Anesthesiology General Surgery news

Prophylactic Tranexamic Acid in General Surgery: Significant Reduction in Major Bleeding Without Thromboembolic Risk

By MedXY 12/24/2025

A systematic review and meta-analysis of 26 RCTs reveals that prophylactic tranexamic acid (TXA) significantly reduces blood loss and transfusion needs in general surgery. While safety profiles are favorable, procedural nuances—particularly in abdominal versus hepatobiliary cases—highlight the importance of tailored clinical application.

news Psychiatry

Processing Speed as a Core Endophenotype: New Evidence from a 115-Study Meta-Analysis in Schizophrenia

By MedXY 12/23/2025

A comprehensive meta-analysis involving over 10,000 patients reveals that processing speed impairment is a profound and central deficit in schizophrenia, showing an effect size of -1.52 and playing a critical role in overall cognitive dysfunction and functional outcomes.

Diabetes & Endocrinology Nephrology news

SGLT2 Inhibitors Reduce Kidney Events, Hospitalization and Death Regardless of Diabetes or Albuminuria: A SMART-C Meta-Analysis Interpretation

By MedXY 11/08/2025

A pooled analysis of 58,816 participants shows SGLT2 inhibitors lower kidney disease progression, AKI, hospitalizations, and mortality across diabetes status and albuminuria levels, with larger absolute kidney benefits where UACR ≥200 mg/g.

news Oncology Urology

Lutetium-177 PSMA Radioligand Therapy Improves Disease Control but Not Yet Overall Survival in mCRPC: A Critical Appraisal of a Six‑RCT Meta-Analysis

By MedXY 11/06/2025

A meta-analysis of six randomized trials shows [177Lu]Lu‑PSMA significantly increases PSA and objective responses and reduces risk of radiographic progression, with no significant increase in high‑grade toxicity and no clear overall survival benefit to date.

Cardiology news

Long-Term Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement: A Meta-Analysis of Time-to-Event Data

By MedXY 10/12/2025

This meta-analysis evaluates 5-year outcomes comparing TAVI and SAVR across risk profiles, revealing early advantages with TAVI that level off long-term, with no significant difference at 5 years.

Gastroenterology Internal Medicine news

Unraveling the Impact of Vitamin D Supplementation on Chronic Liver Disease: Insights from a Comprehensive Meta-Analysis

By MedXY 10/12/2025

Vitamin D supplementation in chronic liver disease modestly improves liver enzymes and insulin resistance, but shows no survival benefit or effects on liver stiffness and fat accumulation. Further large trials are needed to clarify its clinical role.

Neurology Nursing & care Specialties

Enhancing Care for Dementia: The Impact of Dementia Literacy Interventions on Caregivers

By MedXY 10/12/2025

A meta-analysis shows that dementia literacy interventions significantly reduce caregiver burden and improve knowledge, attitudes, and self-efficacy among caregivers of people with dementia.

news OB/GYN & Women's Health Urology

Vaginal Lasers in Stress Urinary Incontinence: Evaluating Efficacy and Safety through an Abridged Cochrane Review

By MedXY 10/12/2025

This article reviews current evidence from a Cochrane systematic review on vaginal laser therapy for stress urinary incontinence in women, highlighting uncertain efficacy and safety profiles compared to sham and other treatments.

Gastroenterology Neurology news

Probiotics and Cognitive Health: Evaluating the Evidence from Systematic Reviews and Meta-Analyses

By MedXY 10/12/2025

An umbrella review synthesizes evidence from 156 RCTs assessing probiotics' effects on cognitive-related outcomes, showing moderate- to high-quality support for cognitive benefits but highlighting need for further trials on strains and dosing.

news Orthopedics Rheumatology

Evaluating Pilates for Knee Osteoarthritis: Efficacy, Safety, and Clinical Insights from Recent Meta-Analysis

By MedXY 10/11/2025

A systematic review and meta-analysis of RCTs indicates Pilates may improve pain and function in knee osteoarthritis patients, though evidence quality is low and safety data insufficient. Caution is warranted in interpreting results, highlighting a need for standardized future research.

Cardiology Internal Medicine news

Quantifying Blood Pressure Reduction: Efficacy of Monotherapy and Combination Antihypertensives in Hypertension Management

By MedXY 10/11/2025

This comprehensive meta-analysis quantifies the efficacy of five major antihypertensive drug classes and their combinations, providing clinicians with evidence-based guidance on blood pressure-lowering intensity to optimize hypertension treatment.

Clinical Updates Neurology news Specialties

Efficacy and Acceptability of Cognitive Behavioral Therapy for Insomnia in Chronic Disease: A Comprehensive Meta-Analysis

By MedXY 09/28/2025

This meta-analysis confirms that cognitive behavioral therapy for insomnia (CBT-I) is an effective, well-accepted treatment improving sleep outcomes across diverse chronic diseases, with minimal adverse effects and potential for broad clinical application.

Medical News news Psychiatry Specialties

Linking Alcohol Consumption Per Capita to Suicide Mortality: Insights from a Meta-Analysis

By MedXY 09/23/2025

A meta-analysis found a population-level association between increased per capita alcohol consumption and higher suicide mortality, without sex differences, suggesting alcohol reduction as a vital component in suicide prevention.

Cardiology news Specialties

Clopidogrel Surpasses Aspirin: Comprehensive Meta-Analysis Shows Superior Secondary Prevention in Coronary Artery Disease

By MedXY 09/02/2025

A large meta-analysis in The Lancet demonstrates that clopidogrel reduces MACCE risk by 14% over aspirin in CAD secondary prevention, with comparable safety over 5.5 years.

Cardiology Medical News news Specialties

TAVI vs SAVR at Low–Intermediate Risk: What the New Individual‑Patient Meta‑Analysis Means for Practice

By MedXY 08/31/2025

A patient‑level meta‑analysis of randomized trials finds transcatheter aortic valve implantation (TAVI) reduces 1‑year risk of death or stroke versus surgical AVR in low– to intermediate‑risk patients—informing patient selection, heart‑team decisions, and follow‑up priorities.

Clinical Updates Neurology news Psychiatry Specialties

Transcranial Magnetic Stimulation: Clinical Advances, Challenges, and Emerging Research Trends

By MedXY 08/19/2025

This review synthesizes recent clinical evidence on transcranial magnetic stimulation across neurological and psychiatric disorders, highlighting efficacy, optimization challenges, and future research directions.

Clinical Updates news Oncology Specialties

Eradication of Helicobacter pylori Significantly Reduces Gastric Cancer Incidence and Mortality, with Clearer Benefits in High-Risk Populations

By MedXY 08/05/2025

A comprehensive meta-analysis confirms that Helicobacter pylori eradication reduces gastric cancer risk and related deaths, especially benefiting high-risk groups, supporting widespread screening and treatment.

Medical News Neurology news Specialties

Why Does Dementia Diagnosis Take So Long? Insights from a Major Meta-Analysis

By MedXY 08/05/2025

A new meta-analysis finds that the average time from dementia symptom onset to diagnosis is 3.5 years, with even longer delays in younger patients and those with frontotemporal dementia.