mechanical ventilation

Persistent Inspiratory Muscle Weakness After Prolonged Intubation: MIP at Day 12 Predicts Failure to Recover in the Acute-Care Stay

By MedXY 11/11/2025

In patients extubated after ≥7 days of mechanical ventilation, 43% had persistent inspiratory muscle weakness at hospital discharge. Maximal inspiratory pressure (MIP) measured 12 days after diagnosis strongly predicted persistent weakness and may guide early rehabilitation and resource allocation.

Critical Care news Respiratory

Trunk Inclination Changes Worsen Compliance and Raise PaCO2 in Obese ARDS Patients: Clinical Implications from a Seven-Study Pooled Analysis

By MedXY 11/07/2025

A secondary analysis of 159 mechanically ventilated ARDS patients shows that increasing trunk inclination reduces respiratory system, lung, and chest wall compliance—especially in patients with obesity—and is associated with increased PaCO2 only in the obese subgroup.

Critical Care Infectious Diseases news

Selective Decontamination of the Digestive Tract in ICU Ventilated Patients: Impact on Mortality and Microbial Ecology

By MedXY 10/31/2025

A large international trial found that selective decontamination of the digestive tract (SDD) during mechanical ventilation did not reduce hospital mortality but decreased bloodstream infections and antibiotic-resistant organisms, with no confirmed ecologic safety.

Critical Care news Rehabilitation Medicine Respiratory

Evaluating the Cost-Effectiveness of Early In-Bed Cycling Plus Routine Physiotherapy in Mechanically Ventilated ICU Patients: Insights from the CYCLE Trial

By MedXY 10/27/2025

This economic evaluation from the CYCLE randomized trial found no significant cost or quality-adjusted life-year benefit by adding early in-bed cycling to usual physiotherapy for ICU patients on mechanical ventilation, underscoring a need for further research to clarify its value.

Clinical Updates Critical Care news Specialties

Proportional-Assist Ventilation vs. Pressure-Support Ventilation: Implications for Liberation from Mechanical Ventilation

By MedXY 09/19/2025

An international trial comparing proportional-assist ventilation (PAV+) with pressure-support ventilation (PSV) showed no significant difference in time to successful liberation from mechanical ventilation among critically ill adults.

Clinical Updates Critical Care Specialties

Proportional-Assist Ventilation and Pressure-Support Ventilation: Comparative Impact on Mechanical Ventilation Duration in Critical Care

By MedXY 09/19/2025

A comprehensive international trial showed that proportional-assist ventilation (PAV+) does not significantly shorten the time to liberation from mechanical ventilation compared to pressure-support ventilation (PSV) in critically ill adults, with comparable safety and secondary outcomes.

Critical Care Neurology Specialties

Lung-Protective Mechanical Ventilation in Acute Brain Injury: Insights from the PROLABI Trial

By MedXY 09/17/2025

The PROLABI trial assessed lung-protective ventilation in acute brain injury patients and found no improvement in mortality, ventilator dependency, or ARDS incidence, highlighting the need for further research in this population.

Anesthesiology news Psychiatry Specialties

Novel Benzodiazepines Intensify Opioid Overdose Severity: A Multicenter ED Study

By MedXY 09/01/2025

Novel benzodiazepine coexposure in opioid overdoses significantly increases the risk of mechanical ventilation and naloxone nonresponse, highlighting a critical challenge in emergency care management.

Critical Care news Specialties

UK-ROX Trial: Conservative Oxygen Strategy in Mechanically Ventilated ICU Patients — No 90‑Day Survival Benefit

By MedXY 08/09/2025

The UK-ROX randomized trial (n=16,500) found that targeting SpO2 90% (88–92%) to reduce oxygen exposure did not reduce 90‑day all‑cause mortality versus usual care in mechanically ventilated adults.